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Start Over Author "Wong ACP" Journal emerging infectious diseases
2 results on '"Wong ACP"'

1. Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells.

Author

Lau SKP, Wong ACP, Luk HKH, Li KSM, Fung J, He Z, Cheng FKK, Chan TTY, Chu S, Aw-Yong KL, Lau TCK, Fung KSC, and Woo PCY

Subjects
Animals, COVID-19, Chiroptera virology, Humans, Middle East Respiratory Syndrome Coronavirus genetics, Middle East Respiratory Syndrome Coronavirus physiology, Pandemics, Severe acute respiratory syndrome-related coronavirus genetics, SARS-CoV-2 genetics, Virus Replication, Severe acute respiratory syndrome-related coronavirus physiology, SARS-CoV-2 physiology, Viral Tropism genetics
Abstract

Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.

Published
2020
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2. Possible Bat Origin of Severe Acute Respiratory Syndrome Coronavirus 2.

Author

Lau SKP, Luk HKH, Wong ACP, Li KSM, Zhu L, He Z, Fung J, Chan TTY, Fung KSC, and Woo PCY

Subjects
Animals, Betacoronavirus classification, Betacoronavirus genetics, Phylogeny, Recombination, Genetic, SARS-CoV-2, Betacoronavirus isolation & purification, Chiroptera virology
Abstract

We showed that severe acute respiratory syndrome coronavirus 2 is probably a novel recombinant virus. Its genome is closest to that of severe acute respiratory syndrome-related coronaviruses from horseshoe bats, and its receptor-binding domain is closest to that of pangolin viruses. Its origin and direct ancestral viruses have not been identified.

Published
2020
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