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1. Hemagglutinin Receptor Binding of a Human Isolate of Influenza A(H10N8) Virus.

Author

Ramos I, Mansour M, Wohlbold TJ, Ermler ME, Hirsh A, Runstadler JA, Fernandez-Sesma A, and Krammer F

Subjects
Animals, Cell Line, Tumor, Dogs, Hemagglutinins chemistry, Humans, Madin Darby Canine Kidney Cells, Protein Binding, Receptors, Virus chemistry, Virus Attachment, Virus Replication, Hemagglutinins physiology, Influenza A Virus, H10N8 Subtype physiology, Receptors, Virus physiology
Abstract

Three cases of influenza A(H10N8) virus infection in humans have been reported; 2 of these infected persons died. Characterization of the receptor binding pattern of H10 hemagglutinin from avian and human isolates showed that both interact weakly with human-like receptors and maintain strong affinity for avian-like receptors.

Published
2015
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