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Start Over Author "Müller, Marcel A." Journal emerging infectious diseases
21 results on '"Müller, Marcel A."'

1. Ongoing Evolution of Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2023-2024.

Author

Hassan, Ahmed M., Mühlemann, Barbara, Al-Subhi, Tagreed L., Rodon, Jordi, El-Kafrawy, Sherif A., Memish, Ziad, Melchert, Julia, Bleicker, Tobias, Mauno, Tiina, Perlman, Stanley, Zumla, Alimuddin, Jones, Terry C., Müller, Marcel A., Corman, Victor M., Drosten, Christian, and Azhar, Esam I.

Subjects
MERS coronavirus, COVID-19 pandemic, CAMELS, NUCLEOTIDE sequencing, GENETIC transcription
Abstract

Middle East respiratory syndrome coronavirus (MERSCoV) circulates in dromedary camels in the Arabian Peninsula and occasionally causes spillover infections in humans. MERS-CoV diversity is poorly understood because of the lack of sampling during the COVID-19 pandemic. We collected 558 swab samples from dromedary camels in Saudi Arabia during November 2023-January 2024. We found 39% were positive for MERS-CoV RNA by reverse transcription PCR. We sequenced 42 MERSCoVs and 7 human 229E-related coronaviruses from camel swab samples by using high-throughput sequencing. Sequences from both viruses formed monophyletic clades apical to recently available genomes. MERS-CoV sequences were most similar to B5 lineage sequences and harbored unique genetic features, including novel amino acid polymorphisms in the spike protein. Further characterization will be required to understand their effects. MERS-CoV spillover into humans poses considerable public health concerns. Our findings indicate surveillance and phenotypic studies are needed to identify and monitor MERS-CoV pandemic potential. [ABSTRACT FROM AUTHOR]

Published
2025
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2. Biphasic MERS-CoV Incidence in Nomadic Dromedaries with Putative Transmission to Humans, Kenya, 2022–2023

Author

Ogoti, Brian Maina, primary, Riitho, Victor, additional, Wildemann, Johanna, additional, Mutono, Nyamai, additional, Tesch, Julia, additional, Rodon, Jordi, additional, Harichandran, Kaneemozhe, additional, Emanuel, Jackson, additional, Möncke-Buchner, Elisabeth, additional, Kiambi, Stella, additional, Oyugi, Julius, additional, Mureithi, Marianne, additional, Corman, Victor M., additional, Drosten, Christian, additional, Thumbi, Samuel M., additional, and Müller, Marcel A., additional

Published
2024
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3. Comparison of Serologic Assays for Middle East Respiratory Syndrome Coronavirus

Author

Harvey, Ruth, Mattiuzzo, Giada, Hassall, Mark, Sieberg, Andrea, Müller, Marcel A., Drosten, Christian, Rigsby, Peter, Caly, L., Li, C., Zhao, L., Tan, W., Peiris, M., Perera, M., Kang, C., Wang, J. S., Haagmans, B., Okba, N. M.A., Gopal, R., Myhill, S., Thornburg, N., and Virology

Subjects
Oman, Comparison of Serologic Assays for Middle East Respiratory Syndrome Coronavirus, Epidemiology, viruses, lcsh:Medicine, serology, Fluorescent Antibody Technique, medicine.disease_cause, Antibodies, Viral, Serology, COVID-19, Saudi Arabia, standard, South Korea, antibodies, MERS-CoV, diagnostics, Coronavirus, Middle East respiratory syndrome coronavirus, Human health, 0302 clinical medicine, 030212 general & internal medicine, Oligonucleotide Array Sequence Analysis, Transmission (medicine), virus diseases, Reference Standards, 3. Good health, Infectious Diseases, Middle East Respiratory Syndrome Coronavirus, Coronavirus Infections, Microbiology (medical), 030231 tropical medicine, Enzyme-Linked Immunosorbent Assay, Sensitivity and Specificity, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Neutralization Tests, medicine, Humans, lcsh:RC109-216, Serologic Tests, business.industry, Research, lcsh:R, Outbreak, Reproducibility of Results, spike, Virology, respiratory tract diseases, Healthcare settings, business
Abstract

Middle East respiratory syndrome coronavirus (MERSCoV) was detected in humans in 2012. Since then, sporadic outbreaks with primary transmission through dromedary camels to humans and outbreaks in healthcare settings have shown that MERS-CoV continues to pose a threat to human health. Several serologic assays for MERS-CoV have been developed globally. We describe a collaborative study to investigate the comparability of serologic assays for MERS-CoV and assess any benefit associated with the introduction of a standard reference reagent for MERS-CoV serology. Our study findings indicate that, when possible, laboratories should use a testing algorithm including >2 tests to ensure correct diagnosis of MERS-CoV. We also demonstrate that the use of a reference reagent greatly improves the agreement between assays, enabling more consistent and therefore more meaningful comparisons between results.

Published
2019
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4. Severe Acute Respiratory Syndrome Coronavirus 2−Specific Antibody Responses in Coronavirus Disease Patients

Author

Okba, Nisreen M.A., primary, Müller, Marcel A., additional, Li, Wentao, additional, Wang, Chunyan, additional, GeurtsvanKessel, Corine H., additional, Corman, Victor M., additional, Lamers, Mart M., additional, Sikkema, Reina S., additional, de Bruin, Erwin, additional, Chandler, Felicity D., additional, Yazdanpanah, Yazdan, additional, Le Hingrat, Quentin, additional, Descamps, Diane, additional, Houhou-Fidouh, Nadhira, additional, Reusken, Chantal B.E.M., additional, Bosch, Berend-Jan, additional, Drosten, Christian, additional, Koopmans, Marion P.G., additional, and Haagmans, Bart L., additional

Published
2020
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5. Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection, Qatar, 2013–2014

Author

Reusken, Chantal B E M, Farag, Elmoubasher A B A, Haagmans, Bart L, Mohran, Khaled A, Godeke, Gert-Jan, Raj, Stalin, Alhajri, Farhoud, Al-Marri, Salih A, Al-Romaihi, Hamad E, Al-Thani, Mohamed, Bosch, Berend-Jan, van der Eijk, Annemiek A, El-Sayed, Ahmed M, Ibrahim, Adel K, Al-Molawi, N, Müller, Marcel A, Pasha, Syed K, Drosten, Christian, AlHajri, Mohd M, Koopmans, Marion P G, LS Virologie, dI&I I&I-1, Virology, LS Virologie, and dI&I I&I-1

Subjects
Microbiology (medical), Risk, medicine.medical_specialty, Camelus, Middle East respiratory syndrome coronavirus, coronavirus, lcsh:Medicine, medicine.disease_cause, Antibodies, Viral, lcsh:Infectious and parasitic diseases, MERS-CoV, MERS, Occupational Exposure, Epidemiology, medicine, camels, Animals, Humans, viruses, lcsh:RC109-216, Risk factor, Qatar, Coronavirus, dromedaries, biology, Transmission (medicine), business.industry, lcsh:R, Dispatch, transmission, Virology, zoonoses, infectious, Infectious Diseases, exposure, Immunology, biology.protein, Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection, Qatar, 2013–2014, epidemiology, Occupational exposure, Antibody, business, Coronavirus Infections, contact
Abstract

We determined the presence of neutralizing antibodies to Middle East respiratory syndrome coronavirus in persons in Qatar with and without dromedary contact. Antibodies were only detected in those with contact, suggesting dromedary exposure as a risk factor for infection. Findings also showed evidence for substantial underestimation of the infection in populations at risk in Qatar.

Published
2015

6. Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Patients.

Author

Okba, Nisreen M. A., Müller, Marcel A., Wentao Li, Chunyan Wang, GeurtsvanKessel, Corine H., Corman, Victor M., Lamers, Mart M., Sikkema, Reina S., de Bruin, Erwin, Chandler, Felicity D., Yazdanpanah, Yazdan, Le Hingrat, Quentin, Descamps, Diane, Houhou-Fidouh, Nadhira, Reusken, Chantal B. E. M., Bosch, Berend-Jan, Drosten, Christian, Koopmans, Marion P. G., Haagmans, Bart L., and Li, Wentao

Subjects
*VIRAL pneumonia, *CLINICAL pathology, *SERODIAGNOSIS, *COVID-19, *EPIDEMICS, *NEUTRALIZATION tests, *ENZYME-linked immunosorbent assay, *VIRAL antibodies
Abstract

A new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently emerged to cause a human pandemic. Although molecular diagnostic tests were rapidly developed, serologic assays are still lacking, yet urgently needed. Validated serologic assays are needed for contact tracing, identifying the viral reservoir, and epidemiologic studies. We developed serologic assays for detection of SARS-CoV-2 neutralizing, spike protein-specific, and nucleocapsid-specific antibodies. Using serum samples from patients with PCR-confirmed SARS-CoV-2 infections, other coronaviruses, or other respiratory pathogenic infections, we validated and tested various antigens in different in-house and commercial ELISAs. We demonstrated that most PCR-confirmed SARS-CoV-2-infected persons seroconverted by 2 weeks after disease onset. We found that commercial S1 IgG or IgA ELISAs were of lower specificity, and sensitivity varied between the 2 assays; the IgA ELISA showed higher sensitivity. Overall, the validated assays described can be instrumental for detection of SARS-CoV-2-specific antibodies for diagnostic, seroepidemiologic, and vaccine evaluation studies. [ABSTRACT FROM AUTHOR]

Published
2020
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7. Antibodies against MERS Coronavirus in Dromedary Camels, United Arab Emirates, 2003 and 2013

Author

Meyer, Benjamin, Müller, Marcel A., Corman, Victor M., Reusken, Chantal B E M, Ritz, Daniel, Godeke, Gert Jan, Lattwein, Erik, Kallies, Stephan, Siemens, Artem, van Beek, Janko, Drexler, Jan F., Muth, Doreen, Bosch, Berend Jan, Wernery, Ulrich, Koopmans, Marion P G, Wernery, Renate, Drosten, Christian, LS Virologie, I&I SIB1, Strategic Infection Biology, LS Virologie, I&I SIB1, Strategic Infection Biology, and Virology

Subjects
Microbiology (medical), endocrine system, Camelus, Epidemiology, Middle East respiratory syndrome coronavirus, viruses, Expedited, coronavirus, lcsh:Medicine, United Arab Emirates, medicine.disease_cause, Antibodies, Viral, Virus, Serology, lcsh:Infectious and parasitic diseases, Antibodies against MERS Coronavirus in Dromedary Camels, United Arab Emirates, 2003 and 2013, MERS-CoV, MERS, Neutralization Tests, medicine, camels, antibodies, Animals, lcsh:RC109-216, serologic analysis, Respiratory Tract Infections, Coronavirus, Respiratory tract infections, business.industry, Research, Middle East respiratory syndrome, lcsh:R, Antibody titer, Outbreak, dromedary camels, Syndrome, medicine.disease, Virology, Antibodies, Neutralizing, 3. Good health, Infectious Diseases, business, Coronavirus Infections
Abstract

Camels were infected with this virus >10 years before the first human cases., Middle East respiratory syndrome coronavirus (MERS-CoV) has caused an ongoing outbreak of severe acute respiratory tract infection in humans in the Arabian Peninsula since 2012. Dromedary camels have been implicated as possible viral reservoirs. We used serologic assays to analyze 651 dromedary camel serum samples from the United Arab Emirates; 151 of 651 samples were obtained in 2003, well before onset of the current epidemic, and 500 serum samples were obtained in 2013. Recombinant spike protein–specific immunofluorescence and virus neutralization tests enabled clear discrimination between MERS-CoV and bovine CoV infections. Most (632/651, 97.1%) camels had antibodies against MERS-CoV. This result included all 151 serum samples obtained in 2003. Most (389/651, 59.8%) serum samples had MERS-CoV–neutralizing antibody titers >1,280. Dromedary camels from the United Arab Emirates were infected at high rates with MERS-CoV or a closely related, probably conspecific, virus long before the first human MERS cases.

Published
2014

9. Antibodies against MERS Coronavirus in Dromedary Camels, Kenya, 1992–2013

Author

Corman, Victor M., Jores, Joerg, Meyer, Benjamin, Younan, Mario, Liljander, Anne, Said, Mohammed Y., Gluecks, Ilona, Lattwein, Erik, Bosch, Berend Jan, Drexler, Jan Felix, Bornstein, Set, Drosten, Christian, Müller, Marcel A., LS Virologie, I&I SIB1, Strategic Infection Biology, LS Virologie, I&I SIB1, Strategic Infection Biology, and Plazi

Subjects
Epidemiology, Expedited, viruses, coronavirus, lcsh:Medicine, Antibodies, Viral, medicine.disease_cause, Animal Diseases, MERS-CoV, antibodies, Viridae, Coronavirus, seroprevalence, Geography, biology, biotic associations, corona viruses, Dispatch, covid, dromedary camels, 3. Good health, Infectious Diseases, covid-19, TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS, Middle East Respiratory Syndrome Coronavirus, Antibody, Coronavirus Infections, CETAF-taskforce, Microbiology (medical), reservoir, endocrine system, Camelus, Coronaviridae, Middle East respiratory syndrome coronavirus, Enzyme-Linked Immunosorbent Assay, History, 21st Century, Virus, virus-host, lcsh:Infectious and parasitic diseases, pathogen-host, medicine, Animals, Humans, Seroprevalence, lcsh:RC109-216, biotic relations, Population Density, ComputingMilieux_THECOMPUTINGPROFESSION, business.industry, lcsh:R, pathogens, History, 20th Century, biotic interaction, Kenya, Virology, zoonoses, TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES, biology.protein, business
Abstract

Dromedary camels are a putative source for human infections with Middle East respiratory syndrome coronavirus. We showed that camels sampled in different regions in Kenya during 1992-2013 have antibodies against this virus. High densities of camel populations correlated with increased seropositivity and might be a factor in predicting long-term virus maintenance.

Published
2014
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10. Time Course of MERS-CoV Infection and Immunity in Dromedary Camels

Author

Meyer, Benjamin, primary, Juhasz, Judit, additional, Barua, Rajib, additional, Das Gupta, Aungshuman, additional, Hakimuddin, Fatima, additional, Corman, Victor M., additional, Müller, Marcel A., additional, Wernery, Ulrich, additional, Drosten, Christian, additional, and Nagy, Peter, additional

Published
2016
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11. MERS-CoV Antibodies in Humans, Africa, 2013–2014

Author

Liljander, Anne, primary, Meyer, Benjamin, additional, Jores, Joerg, additional, Müller, Marcel A., additional, Lattwein, Erik, additional, Njeru, Ian, additional, Bett, Bernard, additional, Drosten, Christian, additional, and Corman, Victor Max, additional

Published
2016
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13. MERS Coronavirus Neutralizing Antibodies in Camels, Eastern Africa, 1983–1997

Author

Müller, Marcel A., primary, Corman, Victor Max, additional, Jores, Joerg, additional, Meyer, Benjamin, additional, Younan, Mario, additional, Liljander, Anne, additional, Bosch, Berend-Jan, additional, Lattwein, Erik, additional, Hilali, Mosaad, additional, Musa, Bakri E., additional, Bornstein, Set, additional, and Drosten, Christian, additional

Published
2014
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14. Human Infection with MERS Coronavirus after Exposure to Infected Camels, Saudi Arabia, 2013

Author

Memish, Ziad A., primary, Cotten, Matthew, additional, Meyer, Benjamin, additional, Watson, Simon J., additional, Alsahafi, Abdullah J., additional, Al Rabeeah, Abdullah A., additional, Corman, Victor Max, additional, Sieberg, Andrea, additional, Makhdoom, Hatem Q., additional, Assiri, Abdullah, additional, Al Masri, Malaki, additional, Aldabbagh, Souhaib, additional, Bosch, Berend-Jan, additional, Beer, Martin, additional, Müller, Marcel A., additional, Kellam, Paul, additional, and Drosten, Christian, additional

Published
2014
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16. Coronavirus antibodies in African bat species.

Author

Müller, Marcel A., Paweska, Janusz T., Leman, Patricia A., Drosten, Christian, Grywna, Klaus, Kemp, Alan, Braack, Leo, Sonnenberg, Karen, Niedrig, Matthias, Swanepoel, Robert, and Müller, Marcel A

Subjects
*BATS, *CORONAVIRUSES, *SARS disease, *IMMUNOGLOBULINS, *ANTIGENS, *SERUM
Abstract

Asian bats have been identified as potential reservoir hosts of coronaviruses associated with severe acute respiratory syndrome (SARS-CoV). We detected antibody reactive with SARS-CoV antigen in 47 (6.7%) of 705 bat serum specimens comprising 26 species collected in Africa; thus, African bats may harbor agents related to putative group 4 CoV. [ABSTRACT FROM AUTHOR]

Published
2007
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17. Amplification of Emerging Viruses in a Bat Colony

Author

Drexler, Jan Felix, primary, Corman, Victor Max, additional, Wegner, Tom, additional, Tateno, Adriana Fumie, additional, Zerbinati, Rodrigo Melim, additional, Gloza-Rausch, Florian, additional, Seebens, Antje, additional, Müller, Marcel A., additional, and Drosten, Christian, additional

Published
2011
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19. Distant Relatives of Severe Acute Respiratory Syndrome Coronavirus and Close Relatives of Human Coronavirus 229E in Bats, Ghana

Author

Pfefferle, Susanne, primary, Oppong, Samuel, additional, Drexler, Jan Felix, additional, Gloza-Rausch, Florian, additional, Ipsen, Anne, additional, Seebens, Antje, additional, Müller, Marcel A., additional, Annan, Augustina, additional, Vallo, Peter, additional, Adu-Sarkodie, Yaw, additional, Kruppa, Thomas F., additional, and Drosten, Christian, additional

Published
2009
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20. Detection and Prevalence Patterns of Group I Coronaviruses in Bats, Northern Germany

Author

Gloza-Rausch, Florian, primary, Ipsen, Anne, additional, Seebens, Antje, additional, Göttsche, Matthias, additional, Panning, Marcus, additional, Drexler, Jan Felix, additional, Petersen, Nadine, additional, Annan, Augustina, additional, Grywna, Klaus, additional, Müller, Marcel, additional, Pfefferle, Susanne, additional, and Drosten, Christian, additional

Published
2008
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21. Antibodies against MERS Coronavirus in Dromedaries, United Arab Emirates, 2003 and 2013.

Author

Meyer, Benjamin, Müller, Marcel A., Corman, Victor M., Reusken, Chantal B. E. M., Ritz, Daniel, Godeke, Gert-Jan, Lattwein, Erik, Kallies, Stephan, Siemens, Artem, van Beek, Janko, Drexler, Jan F., Muth, Doreen, Bosch, Berend-Jan, Wernery, Ulrich, Koopmans, Marion P. G., Wernery, Renate, and Drosten, Christian

Subjects
*CORONAVIRUSES, *CORONAVIRUS diseases, *RESPIRATORY diseases, *RESPIRATORY infections, *IMMUNOFLUORESCENCE, *VIRUS diseases, *CAMEL diseases
Abstract

Middle East respiratory syndrome coronavirus (MERSCoV) has caused an ongoing outbreak of severe acute respiratory tract infection in humans in the Arabian Peninsula since 2012. Dromedaries have been implicated as possible viral reservoirs. We used serologic assays to analyze 651 dromedary serum samples from the United Arab Emirates; 151 of 651 samples were obtained in 2003, well before onset of the current epidemic, and 500 serum samples were obtained in 2013. Recombinant spike protein-specific immunofluorescence and virus neutralization tests enabled clear discrimination between MERS-CoV and bovine CoV infections. Most (632/651, 97.1%) dromedaries had antibodies against MERS-CoV. This result included all 151 serum samples obtained in 2003. Most (389/651, 59.8%) serum samples had MERS-CoV neutralizing antibody titers >1,280. Dromedaries from the United Arab Emirates were infected at high rates with MERS-CoV or a closely related, probably conspecific, virus long before the first human MERS cases. [ABSTRACT FROM AUTHOR]

Published
2014
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