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Start Over Author "Chia-Jen Shih" Journal emerging infectious diseases
3 results on '"Chia-Jen Shih"'

1. Statin Use and Influenza Vaccine Effectiveness in Persons ≥ 65 Years of Age, Taiwan

Author

Lung-Wen Tsai, Yung-Tai Chen, Chia-Jen Shih, Shuo-Ming Ou, Pei-Wen Chao, and Shih-Hsiu Lo

Subjects
critical illness, vaccine-preventable diseases, influenza, hospitalization, vaccines, viruses, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

Debates on whether statin use reduces the effectiveness of influenza vaccines against critical illness and death among persons >65 years of age continue. We conducted a study of 9,427,392 persons >65 years of age who did and did not receive influenza vaccinations during 12 consecutive influenza seasons, 2000–01 through 2011–12. Using data from Taiwan’s National Health Insurance Research Database, we performed propensity score-matching to compare vaccinated persons with unvaccinated controls. After propensity score-matching, the vaccinated group had lower risks for in-hospital death from influenza and pneumonia and for hospitalization for pneumonia and influenza, circulatory conditions, and critical illnesses compared with the unvaccinated group. We stratified the 2 groups by statin use and analyzed data by interaction analysis and saw no statistically significant difference. We found that influenza vaccine effectively reduced risks for hospitalization and death in persons >65 years of age, regardless of statin use.

Published
2020
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2. Statin Use and Influenza Vaccine Effectiveness in Persons ≥ 65 Years of Age, Taiwan

Author

Chia Jen Shih, Shuo Ming Ou, Yung Tai Chen, Pei Wen Chao, Shih Hsiu Lo, and Lung Wen Tsai

Subjects
Microbiology (medical), medicine.medical_specialty, Epidemiology, Influenza vaccine, 030231 tropical medicine, Taiwan, lcsh:Medicine, Influenza vaccinations, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Influenza, Human, medicine, Humans, critical illness, viruses, lcsh:RC109-216, 030212 general & internal medicine, cardiovascular diseases, Hospital Mortality, business.industry, respiratory diseases, Research, Significant difference, Vaccination, lcsh:R, virus diseases, nutritional and metabolic diseases, Statin treatment, vaccines, medicine.disease, Pneumonia, Infectious Diseases, vaccine-preventable diseases, National health insurance, Influenza Vaccines, Critical illness, Vaccine-preventable diseases, lipids (amino acids, peptides, and proteins), Statin Use and Influenza Vaccine Effectiveness in Persons ≥ 65 Years of Age, Taiwan, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, influenza, hospitalization
Abstract

Influenza vaccine effectively reduced risks for in-hospital death or hospitalization, regardless of statin use., Debates on whether statin use reduces the effectiveness of influenza vaccines against critical illness and death among persons >65 years of age continue. We conducted a study of 9,427,392 persons >65 years of age who did and did not receive influenza vaccinations during 12 consecutive influenza seasons, 2000–01 through 2011–12. Using data from Taiwan’s National Health Insurance Research Database, we performed propensity score-matching to compare vaccinated persons with unvaccinated controls. After propensity score-matching, the vaccinated group had lower risks for in-hospital death from influenza and pneumonia and for hospitalization for pneumonia and influenza, circulatory conditions, and critical illnesses compared with the unvaccinated group. We stratified the 2 groups by statin use and analyzed data by interaction analysis and saw no statistically significant difference. We found that influenza vaccine effectively reduced risks for hospitalization and death in persons >65 years of age, regardless of statin use.

Published
2020

3. Statin Use and Influenza Vaccine Effectiveness in Persons >65 Years of Age, Taiwan.

Author

Lung-Wen Tsai, Yung-Tai Chen, Chia-Jen Shih, Shuo-Ming Ou, Pei-Wen Chao, Shih-Hsiu Lo, Tsai, Lung-Wen, Chen, Yung-Tai, Shih, Chia-Jen, Ou, Shuo-Ming, Chao, Pei-Wen, and Lo, Shih-Hsiu

Subjects
VACCINE effectiveness, INFLUENZA vaccines, CRITICALLY ill, INFLUENZA
Abstract

Debates on whether statin use reduces the effectiveness of influenza vaccines against critical illness and death among persons >65 years of age continue. We conducted a study of 9,427,392 persons >65 years of age who did and did not receive influenza vaccinations during 12 consecutive influenza seasons, 2000-01 through 2011-12. Using data from Taiwan's National Health Insurance Research Database, we performed propensity score-matching to compare vaccinated persons with unvaccinated controls. After propensity score-matching, the vaccinated group had lower risks for in-hospital death from influenza and pneumonia and for hospitalization for pneumonia and influenza, circulatory conditions, and critical illnesses compared with the unvaccinated group. We stratified the 2 groups by statin use and analyzed data by interaction analysis and saw no statistically significant difference. We found that influenza vaccine effectively reduced risks for hospitalization and death in persons >65 years of age, regardless of statin use. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
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