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Your search keyword '"Brendan McMullan"' showing total 4 results
Start Over Author "Brendan McMullan" Journal emerging infectious diseases
4 results on '"Brendan McMullan"'

1. Fatal Human Neurologic Infection Caused by Pigeon Avian Paramyxovirus-1, Australia

Author

Siobhan Hurley, John Sebastian Eden, John Bingham, Michael Rodriguez, Matthew J. Neave, Alexandra Johnson, Annaleise R. Howard-Jones, Jen Kok, Antoinette Anazodo, Brendan McMullan, David T. Williams, James Watson, Annalisa Solinas, Ki Wook Kim, and William Rawlinson

Subjects
avian paramyxovirus-1, metagenomics, Newcastle disease virus, zoonoses, brain, histopathology, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

Avian paramyxovirus type 1 (APMV-1) is a virus of birds that results in a range of outcomes, from asymptomatic infections to outbreaks of systemic respiratory and neurologic disease, depending on the virus strain and the avian species affected. Humans are rarely affected; those who are predominantly experience mild conjunctivitis. We report a fatal case of neurologic disease in a 2-year-old immunocompromised child in Australia. Metagenomic sequencing and histopathology identified the causative agent as the pigeon variant of APMV-1. This diagnosis should be considered in neurologic conditions of undefined etiologies. Agnostic metagenomic sequencing methods are useful in such settings to direct diagnostic and therapeutic efforts.

Published
2023
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2. Seroepidemiology of Parechovirus A3 Neutralizing Antibodies, Australia, the Netherlands, and United States

Author

Eveliina Karelehto, Lieke Brouwer, Kimberley Benschop, Jen Kok, Kerri Basile, Brendan McMullan, William Rawlinson, Julian Druce, Suellen Nicholson, Rangaraj Selvarangan, Christopher Harrison, Kamani Lankachandra, Hetty van Eijk, Gerrit Koen, Menno de Jong, Dasja Pajkrt, and Katja C. Wolthers

Subjects
Picornaviruses, parechovirus A3, outbreak, neutralizing antibody, seroprevalence, seroepidemiology, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

Recent parechovirus A3 (PeV-A3) outbreaks in Australia suggest lower population immunity compared with regions that have endemic PeV-A3 circulation. A serosurvey among populations in the Netherlands, the United States, and Australia before and after the 2013 Australia outbreak showed high PeV-A3 neutralizing antibody prevalence across all regions and time periods, indicating widespread circulation.

Published
2019
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3. Seroepidemiology of parechovirus A3 neutralizing antibodies, Australia, The Netherlands, and United States

Author

William D. Rawlinson, Christopher J. Harrison, Lieke Brouwer, Kerri Basile, Julian Druce, Katja C. Wolthers, Brendan McMullan, Eveliina Karelehto, Gerrit Koen, Menno de Jong, Hetty van Eijk, Rangaraj Selvarangan, Suellen Nicholson, Kamani Lankachandra, Kimberley S. M. Benschop, Jen Kok, Dasja Pajkrt, Graduate School, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Paediatric Infectious Diseases / Rheumatology / Immunology, and Amsterdam Reproduction & Development (AR&D)

Subjects
Male, Epidemiology, Parechovirus, lcsh:Medicine, Antibodies, Viral, Disease Outbreaks, 0302 clinical medicine, Seroepidemiologic Studies, 030212 general & internal medicine, Neutralizing antibody, Child, Netherlands, seroprevalence, Dispatch, neutralizing antibody, Middle Aged, Infectious Diseases, Child, Preschool, Seroepidemiology of Parechovirus A3 Neutralizing Antibodies, Australia, the Netherlands, and United States, Female, Antibody, seroepidemiology, Microbiology (medical), Adult, Adolescent, 030231 tropical medicine, Picornaviruses, Biology, Herd immunity, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Young Adult, Seroprevalence, Humans, viruses, lcsh:RC109-216, Picornaviridae Infections, Aged, outbreak, the Netherlands, lcsh:R, fungi, Australia, Outbreak, Infant, biology.organism_classification, Virology, Antibodies, Neutralizing, United States, Cross-Sectional Studies, parechovirus A3, biology.protein
Abstract

Recent parechovirus A3 (PeV-A3) outbreaks in Australia suggest lower population immunity compared with regions that have endemic PeV-A3 circulation. A serosurvey among populations in the Netherlands, the United States, and Australia before and after the 2013 Australia outbreak showed high PeV-A3 neutralizing antibody prevalence across all regions and time periods, indicating widespread circulation.

Published
2019

4. Parechovirus Genotype 3 Outbreak among Infants, New South Wales, Australia, 2013-2014

Author

Kit Leung, Brendan McMullan, Jennie Musto, Georgina Papadakis, Mark J Ferson, Oanh Nguyen, Ameneh Khatami, Germaine Cumming, and Vicky Sheppeard

Subjects
Microbiology (medical), Male, Pediatrics, medicine.medical_specialty, Genes, Viral, Genotype, Epidemiology, human parechovirus 3, piconarvirus, lcsh:Medicine, Parechovirus, Irritability, piconarvirus, lcsh:Infectious and parasitic diseases, Disease Outbreaks, Parechovirus Genotype 3 Outbreak among Infants, New South Wales, Australia, 2013–2014, Public health surveillance, human parechovirus 3, Medicine, Humans, neonatal infection, lcsh:RC109-216, viruses, Picornaviridae Infections, biology, business.industry, sepsis-like syndrome, Research, Human parechovirus, lcsh:R, Infant, Newborn, Australia, Outbreak, Infant, Emergency department, biology.organism_classification, Rash, infantile fever, public health surveillance, Neonatal infection, Infectious Diseases, Molecular Diagnostic Techniques, skin rash, Epidemiological Monitoring, infantile fever, neonatal infection, sepsis-like syndrome, skin rash, emerging infectious disease, public health surveillance, viruses, New South Wale, Female, medicine.symptom, New South Wales, business
Abstract

Syndromic surveillance was useful for outbreak monitoring, and public health response helped reduce hospitalization times., From October 2013 through February 2014, human parechovirus genotype 3 infection was identified in 183 infants in New South Wales, Australia. Of those infants, 57% were male and 95% required hospitalization. Common signs and symptoms were fever >38°C (86%), irritability (80%), tachycardia (68%), and rash (62%). Compared with affected infants in the Northern Hemisphere, infants in New South Wales were slightly older, both sexes were affected more equally, and rash occurred with considerably higher frequency. The New South Wales syndromic surveillance system, which uses near real-time emergency department and ambulance data, was useful for monitoring the outbreak. An alert distributed to clinicians reduced unnecessary hospitalization for patients with suspected sepsis.

Published
2015

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