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Your search keyword '"Sergey Ryazanov"' showing total 2 results
Start Over Author "Sergey Ryazanov" Journal embo molecular medicine
2 results on '"Sergey Ryazanov"'

1. The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology

Author

Ana Martinez Hernandez, Hendrik Urbanke, Alan L Gillman, Joon Lee, Sergey Ryazanov, Hope Y Agbemenyah, Eva Benito, Gaurav Jain, Lalit Kaurani, Gayane Grigorian, Andrei Leonov, Nasrollah Rezaei‐Ghaleh, Petra Wilken, Fernando Teran Arce, Jens Wagner, Martin Fuhrmann, Mario Caruana, Angelique Camilleri, Neville Vassallo, Markus Zweckstetter, Roland Benz, Armin Giese, Anja Schneider, Martin Korte, Ratnesh Lal, Christian Griesinger, Gregor Eichele, and Andre Fischer

Subjects
Alzheimer's disease, amyloid pathology, Aβ channels, gene expression, membrane pores, Medicine (General), R5-920, Genetics, QH426-470
Abstract

Abstract Alzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology. At the mechanistic level, we provide evidence that anle138b blocks the activity of conducting Aβ pores without changing the membrane embedded Aβ‐oligomer structure. In conclusion, our data suggest that anle138b is a novel and promising compound to treat AD‐related pathology that should be investigated further.

Published
2017
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2. The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology

Author

Roland Benz, Martin Fuhrman, Hope Y Agbemenyah, Joon Lee, Lalit Kaurani, Gregor Eichele, Markus Zweckstetter, Gaurav Jain, Nasrollah Rezaei-Ghaleh, Andre Fischer, Alan L. Gillman, Gayane Grigorian, Ratnesh Lal, Sergey Ryazanov, Mario Caruana, Armin Giese, Christian Griesinger, Martin Korte, Eva Benito, Angelique Camilleri, Andrei Leonov, Neville Vassallo, Jens Wagner, Fernando Teran Arce, Hendrik Urbanke, Ana Martinez Hernandez, Anja Schneider, and Petra Wilken

Subjects
0301 basic medicine, Male, 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole, Medicine (General), drug effects [Hippocampus], Hippocampus, genetics [Alzheimer Disease], metabolism [Hippocampus], Disease, Hippocampal formation, QH426-470, therapeutic use [Benzodioxoles], Inbred C57BL, Medical and Health Sciences, Transcriptome, Mice, 0302 clinical medicine, drug effects [Neuronal Plasticity], drug therapy [Alzheimer Disease], genetics [Amyloid beta-Peptides], Amyloid beta-protein, Spatial Memory, Neuronal Plasticity, Alzheimer's disease -- Pathophysiology, membrane pores, Biological Sciences, Alzheimer's disease, Phenotype, 3. Good health, Alzheimer's disease -- Treatment, drug effects [Transcriptome], therapeutic use [Pyrazoles], Molecular Medicine, drug effects [Spatial Memory], A beta channels, metabolism [Alzheimer Disease], metabolism [Amyloid beta-Peptides], pharmacology [Benzodioxoles], Aβ channels, physiopathology [Alzheimer Disease], 03 medical and health sciences, R5-920, Alzheimer Disease, Neuroplasticity, medicine, Genetics, Dementia, Animals, ddc:610, Benzodioxoles, Amyloid beta-Peptides, business.industry, Animal, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Alzheimers disease, Plaque, amyloid -- Physiopathology, Disease Models, physiopathology [Hippocampus], gene expression, Pyrazoles, amyloid pathology, business, pharmacology [Pyrazoles], Neuroscience, 030217 neurology & neurosurgery, Nervous system -- Degeneration
Abstract

Alzheimer’s disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer’s disease, when given orally before or after the onset of pathology. At the mechanistic level, we provide evidence that anle138b blocks the activity of conducting Ab pores without changing the membrane embedded Ab-oligomer structure. In conclusion, our data suggest that anle138b is a novel and promising compound to treat AD-related pathology that should be investigated further., peer-reviewed

Published
2018
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