1. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression.
- Author
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Andreev, Dmitry E., O'Connor, Patrick BF, Fahey, Ciara, Kenny, Elaine M., Terenin, Ilya M., Dmitriev, Sergey E., Cormican, Paul, Morris, Derek W., Shatsky, Ivan N., and Baranov, Pavel V.
- Subjects
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SODIUM arsenite , *PROTEIN synthesis , *EUKARYOTIC cells , *PHOSPHORYLATION , *CELLS - Abstract
The article examines the immediate effect of sodium arsenite treatment on protein synthesis. Topics discussed include the role of eukaryotic cells in the rapid reduction in protein synthesis in response to various stress conditions and the phosphorylation-mediated inactivation of the eukaryotic initiation factor 2. The presence of at least one efficiently translated upstream open reading frame in nearly all resistant transcripts and its role in functional protein product encoding are mentioned.
- Published
- 2015
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