1. Enhancing signals of microfluidic impedance cytometry through optimization of microelectrode array.
- Author
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Zhou C, Shen H, Feng H, Yan Z, Ji B, Yuan X, Zhang R, and Chang H
- Subjects
- Microelectrodes, Electric Impedance, Flow Cytometry, Microfluidics, Microfluidic Analytical Techniques
- Abstract
Microfluidic impedance cytometry shows a great value in biomedical diagnosis. However, the crosstalk between neighboring microelectrodes strongly weakens the impedance signal. Hereby, we demonstrate a novel microfluidic impedance cytometer consisted of sensing electrodes and ground electrodes (GNDs). The simulation reveals a signal enhancement by more than five times with GNDs compared to that without ones. We also found that the linear correlation between the impedance at a high frequency and that at a low frequency varies as microparticle size changes, which can be used for microparticle classification. The study can help with microelectrode optimization and signal processing for microfluidic impedance analysis., (© 2022 Wiley-VCH GmbH.)
- Published
- 2022
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