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Presented is a new method for implementing sensor arrays for in vitro recording of neural action potentials. A key feature of the system is that it is divided into two parts, i.e. neural activity detection and neural recording, which softens key design trade-offs such as noise, power, sensor pitch, and observability. The term observability is defined as the percentage of the total sensors that can be monitored in real time. This system should provide high observability, low noise, low power and reasonable pitch with all these key specifications within acceptable limits compared to the state-of-the-art work where at least one of these key specifications is severely sacrificed in the pursuit of others. A 16×16 sub-array system for in vitro neural front-end recording has been implemented in 0.35 µm CMOS and electrical measurement results are presented. [ABSTRACT FROM AUTHOR]

The first integrated CMOS multichannel electroencephalogram (EEG) readout front-end, capable of extracting EEG signals from conventional AgCl electrodes without the use of any trimmed components, is presented. Each channel of the ASIC achieves better than 90 dB common-mode rejection ratio (CMRR) at 50 Hz with 50 mV DC offset between EEG electrodes. This is consistent with the presented formula describing the CMRR behaviour of the preamplifier under DC electrode offset. The front-end includes 24 channels and consumes 10.5 mW from a 3 V supply. [ABSTRACT FROM AUTHOR]