1. Small fibre involvement in neuropathy associated with IgG, IgA and IgM monoclonal gammopathy
- Author
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Barbieri, S., Sandroni, P., Nobile-Orazio, E., Cappellari, A., Cavestro, C., Luca Baldini, and Scarlato, G.
- Subjects
Male ,Nerve Fibers ,Immunoglobulin M ,Immunoglobulin G ,Neural Conduction ,Paraproteinemias ,Humans ,Female ,Middle Aged ,Nervous System Diseases ,Aged ,Immunoglobulin A - Abstract
A delta and C fibre function has been investigated in 18 patients affected by neuropathies associated with monoclonal gammopathies. Warm, cold and heat pain thresholds have been determined by means of a Somedic Thermotest, operating on the Peltier principle, in a room at constant temperature. Our results indicate that: 1) there is an involvement of A delta and C fibres in these neuropathies that might be difficult to quantitate only on clinical grounds 2) in IgG and IgA patients, all affected by a subclinical or mild axonal neuropathy, small fibres of both types are always involved 3) in IgM anti-MAG positive severe cases, A delta fibre involvement, suggestive of demyelination is evident, while in one anti-MAG negative patient only C fibres are damaged, probably reflecting a different pathogenetic mechanism.
- Published
- 1995