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1. [Electromyographic and histopathological study of the Lambert-Eaton myasthenia syndrome. Apropos of a case].

Author

Dudognon P, Cathala HP, Fardeau M, Ribabeau-Dumas JL, and Labrousse G

Subjects
Action Potentials drug effects, Edrophonium pharmacology, Electric Stimulation, Electromyography, Humans, Male, Middle Aged, Motor Endplate pathology, Muscular Diseases pathology, Syndrome, Muscular Diseases physiopathology
Abstract

In this case of Eaton-Lambert myasthenic syndrome the electrophysiological study demonstrated some modifications of latency of the muscle action potentials evoked by repetitive nerve stimulation at 30 c/sec. specially after administration of edrophonium chloride. This data suggest as possible some fluctuations in the mechanism of the neuromuscular transmission defect. The muscle biopsy showed changes secondary to a peripheral motor nerve involvement; electronmicroscopic study of the motor end-plates revealed a highly developped subneural apparatus.

Published
1980

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