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The MnO@nitrogen doped carbon microspheres with a yolk-shell structure (YS-MnO@NC) is reported. As an anode for lithium ion battery, the YS-MnO@NC exhibits a very high reversible capacity (1280 mA h g−1 at 0.1 A g−1), superior rate capability (capacities of 1090, 860, 700, 545, and 390 mA h g−1 at 0.2, 0.5, 1.0, 2.0, and 5.0 A g−1, respectively), and stable cycling performance (880 mA h g−1 at 1.0 A g−1 after 1000 cycles). The reversible capacity and cyclability of YS-MnO@NC is higher than MnO based materials reported previously. Its remarkable performance is attributable to the unique yolk-shell structure and the presence of the NC shell. Specifically, the yolk-shell structure improves its structural stability during the repeated cycles due to the presence of the internal void between the core and shell, while the NC shell increases its electric conductivity and wettability toward the electrolyte solution. Additionally, the nitrogen doped structure also promotes a strong electronic coupling between MnO and NC. The in operando X-ray diffraction studies show that the MnO core and hollow NC microsphere play comparatively equal contributions on the high performance of the YS-MnO@NC. Both the NC shell and MnO microsphere exhibit high reversibility in lithiation and delithiation.

Electrochemical oxygen reduction reaction (ORR) represents a crucial cathodic process of different fuel cells. The development of highly active and stable noble metal-free ORR electrocatalysts remains as one of major challenges. Herein, we report cobalt/nitrogen co-doped porous carbon materials (Co-N-C) from well-designed bimetal-organic frameworks (Zn100-xCox-ZIF) as efficient ORR electrocatalysts in both pH-neutral and alkaline solutions. The compositional and structural features, and the corresponding ORR activity can be tailored by tuning the Zn/Co ratio in the precursor. Remarkable features of large surface-area and suitable graphitization degree and well-dispersed Co-N-C moieties, enable a high catalytic efficiency. The optimized electrocatalyst registers considerable ORR performance with a high half-wave potential of 0.65 V vs RHE and a saturated current density of 5.30 mA cm−2 close to the value of the commercial Pt/C in 0.1 M pH 7.0 PBS, and considerable operational stability and tolerance to glucose. A preliminary one-compartment hybrid glucose/O2 enzymatic biofuel cell, consisting of Co-N-C-10 abiotic cathode and glucose oxidising bioanode, is constructed and tested. Furthermore, Co-N-C also presents reasonable ORR electrocatalytic activity and operational stability in alkaline condition.

High temperature pyrolysis needs complicated and harsh preparative condition, such as inert gas protection, long reaction time and high pyrolysis temperature. This work reported that a cobalt-ruthenium nanoalloy coated with nitrogen- doped graphene (CoRu@NG-x) was rapidly prepared from Ru-ZIF-67 as precursors by laser engraving in air environment and at room temperature for the first time. The addition of a small amount of ruthenium in cobalt can further improve the hydrogen catalytic performance. CoRu@NG-3 (Ru, 0.18wt%) is an efficient HER electrocatalyst in a wide pH range. Compared with the reported ruthenium alloys, the content of ruthenium in CoRu@NG-3 is the lowest. It's worth noting that the optimal CoRu@NG-3 shows overpotentials of 62, 52 and 88 mV at the current density of 10 mA cm−2 in 1.0 M KOH, 0.5 M H2SO4 and 1.0 M PBS solution for HER catalysis. CoRu@NG-3 also has a good stability under all pH conditions. This study may offer a novel strategy to rapidly prepare electrode materials at room temperature and in the air.

In this work, a novel porphyrinic metal-organic framework-based composite has been successfully synthesized by a simple one-step solvothermal method through growing Zr-PorMOF on macroporous carbon (MPC). Porphyrin-base MOFs combining the structural adjustable of MOFs and the specific catalytic activity of biomimetic catalysts play an important role in electrocatalysis. A series of characterization show that the roles of MPC as follow: (1) MPC could avoid the agglomeration of Zr-PorMOF particles and increase the specific surface area; (2) MPC could improve the electrochemical stability of Zr-PorMOF particles; (3) MPC could reduce the electron transfer resistance. Therefore, MPC plays the role of the conductive bridges to provide facile charge transport. The obtained Zr-PorMOF/MPC composites exhibit much better electrocatalytic activity for the reduction of hydrogen peroxide (H2O2) than the pristine Zr-PorMOF due to the synergy of Zr-PorMOF and MPC. This enzyme-free H2O2 sensor shows two linear relationships in the ranges 0.5–137 μM (R2 = 0.991, sensitivity = 66 μA mM−1) and 137–3587 μM (R2 = 0.993, sensitivity = 16 μA mM−1), with a low over-potential at −0.2 V, a fast response time within 1 s and a low limit of detection (LOD) of 0.18 μM. Moreover, Zr-PorMOF/MPC composites were used to simultaneously detect uric acid (UA), xanthine (XA) and hypoxanthine (HX). These three substances are degradation products of purine metabolism. In addition, Zr-PorMOF/MPC composites can be used to develop multifunctional biosensors.

In the present work, we described a green and facile fabrication of mixed manganese-iron oxide loaded carbon fibers (Mn2O3-Fe2O3/CFs) through electrospinning and subsequent heat treatment processes. For optimal performance, a series of samples were synthesized by the same way with varying Mn/Fe molar ratios (1:0, 3:1, 1:1, 1:3, 0:1) in precursors. The composition, morphology and catalytic property of as-prepared samples were characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), X-ray powder diffraction (XRD), X-ray photo-electron spectroscopy (XPS) and electrochemical methods. Mn2O3-Fe2O3/CFs (3:1) exhibits the highest catalytic ability towards hydrogen peroxide (H2O2) reduction and hydrazine (N2H4) oxidation. Furthermore, Mn2O3-Fe2O3/CFs/GCE (3:1) displays remarkable analytical performances for the detection of H2O2 and N2H4 in terms of wide linear range, low limit of detection, short current response time, excellent anti-interference ability, good repeatability and long-time stability. In addition, it can be applied to the analysis of real samples with satisfactory results.

Herein, a composite of Pt loaded on the support of porous graphene with ionic liquids (Pt-IL-pGR) was synthesized by a one-step electrochemical reduction route. The formation and structure of the synthesized Pt-IL-pGR nanostructure was systematically characterized by SEM, XRD, EIS and XPS and the results suggest the existence of the porosity in graphene as well as the uniform distribution of Pt NPs on the pGR surface with the help of IL. For the further study, we used the material as the electrocatalyst for both methanol oxidation reaction (MOR) and electrochemical detection of hydrogen peroxide (H2O2). The present investigations certified that the Pt-IL-pGR nanocomposite processes excellent electrochemical performance and it also provides a new generic approach for designing multifunctional metallic nanoparticles-GR catalysts.

The development of highly-efficient and noble-metal-free catalysts with low cost and high durability for hydrogen evolution reaction (HER) is of great importance to many energy-related technologies. This work reports that nitrogen-doped carbon coated Co nanoparticles encapsulated in bamboo-like nitrogen-doped carbon nanotubes (Co@NC/B-NCNTs), synthesized by a simple calcination of Co(NO3)2, melamine and P123, is a promising catalyst for HER in both acidic and alkaline solutions. In acidic solution, the Co@NC/B-NCNTs has the HER onset potential of ∼0 V and only needs an overpotential of 7 mV to drive the current density of 10 mA cm−2. Its HER catalytic activity is very close to that of Pt/C. In alkaline solution, its onset potential and overpotential to drive 10 mA cm−2 are 100 and 182 mV, respectively. Both the values are lower than those of many other catalysts reported. The DFT calculations show electronic coupling between Co nanoparticles and NC layer plays an important role in high catalytic activity of Co@NC/B-NCNTs. The Co nanoparticles can change the charge density distribution of the outer NC layer, affecting its properties for hydrogen adsorption and desorption. Additionally, the pyridinic N in the outer NC layer is calculated to be a promising active site for HER.

Copper oxide nanoparticles were anchored on porous reduced graphene oxide (PrGO) by a simple and mild hydrothermal method. The as-prepared product was characterized by X-ray diffraction, N 2 adsorption–desorption isotherms, scanning electron microscopy, and used to build a novel glucose sensor. The CuO/PrGO nanocomposite showed an enhanced electrocatalytic activity to direct glucose oxidation compared with the non-porous reduced graphene oxide-CuO (CuO/rGO). The CuO/PrGO modified glass carbon electrode (CuO/PrGO-GCE) responded linearly to glucose in the range of 0.001 to 6 mM and the detection limit of the transducer was found to be 0.50 μM. High reproducibility, wide linear range, good anti-interference, stability and enough precision in real sample analysis made it promising for the development of enzyme-free sensors.

By using eco-friendly polydopamine as carbon and nitrogen precursor and commercial hydrophilic nano-CaCO 3 as hard-template; a one step, cost-effective and green method to synthesize nitrogen-doped porous carbon (NPC) is presented. A series of NPC samples with different nitrogen contents have been reported. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectra (EDX), fourier transform infrared spectroscopy (IR), Raman spectroscopy, X-ray diffraction (XRD), nitrogen adsorption-desorption and X-ray photoelectron spectra (XPS) were employed for characterizations of NPC. The influence of BET surface area and different amounts of N-bonding configurations of NPC for the electrocatalysis towards nitrobenzene (NB) and hydrazine (N 2 H 4 ) were investigated in detail. Results indicated that NPC with largest BET surface area and highest amounts of pyrrolic N and graphitic N showed improved electrocatalytic activity for NB and N 2 H 4 in neutral solution.

Phosphorus-doped ordered mesoporous carbons (POMCs) with different P content are successfully synthesized by hard template method using SBA-15 as hard template, sucrose as carbon precursor and triphenylphosphane as phosphorus precursor. Pt nanoparticles with size of 3.5 ± 0.4 nm are deposited on the framework of POMCs. The doping of P into OMCs facilitates the dispersion of Pt nanoparticles and accelerates the formation of oxygen-containing functional groups. Pt/POMCs nanocomposites were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy, nitrogen adsorption–desorption and X-ray photoelectron spectroscopy (XPS). Cyclic voltammetry and chronoamperometry studies exhibit that the Pt/POMCs, especially Pt/P 7 OMCs, have larger electrochemical active surface area (ECSA), higher electrocatalytic activity, more negative onset potential and long-time stability for the electrooxidation toward methanol than that of Pt/OMCs, PtRu/XC and commercial Pt/C catalysts. These enhanced performances indicate that Pt/P 7 OMCs catalyst may be an excellent anode catalyst for direct methanol fuel cell (DMFC).

Boron-doped graphene (BGR) is prepared by thermal annealing of graphene oxide (GO) in the presence of boric acid. More defective sites are introduced into GR accompanied by the doping of boron. Low electron transfer resistance towards redox probe is observed at BGR. The BGR modified electrode can effectively distinguish the anodic peaks for ascorbic acid (AA), dopamine (DA), and uric acid (UA). The defective sites of BGR can also act as anchoring sites for the deposition of Pt nanoparticles. When used as a support for Pt electrocatalysts, Pt nanoparticles with an average diameter of 3.2 nm are deposited on BGR. The doping of boron into GR facilitates the dispersion of Pt nanoparticles and increases the utilization efficiency of Pt nanoparticles. The Pt/BGR exhibits significant catalytic activity towards the oxidation of methanol. The results demonstrate that BGR is a good support for Pt catalysts or an electrode material compared with the undoped GR.

Sulfur-doped ordered mesoporous carbons (OMC-S-X) (X = 1, 2 and 3) with different sulfur contents were synthesized as metal-free electrocatalyst for oxygen reduction reaction (ORR). Transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray spectra (EDX), nitrogen adsorption–desorption, X-ray diffraction (XRD) and X-ray photoelectron spectra (XPS) were employed to confirm the characterizations of OMC and OMC-S. The prepared OMC-S-3 exhibits high electrocatalytic activity, good stability and excellent tolerance to crossover effect for ORR. The high electrocatalytic activity of OMC-S-3 for ORR can be mainly ascribed to the doping of sulfur especially the existence of sulfide groups ( C S C ) which play an important role in promoting the ORR.

In this work, nitrogen-doped ordered mesoporous carbons (N-OMCs) were synthesized by a low cost and simple nanocasting method using SBA-15 as a template and honey as a nitrogen and carbon sources. Transmission electron microscopy (TEM), scanning electron microscopy (SEM), nitrogen adsorption-desorption, X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) showed that nitrogen was successfully doped into the framework of ordered mesoporous carbon rods. The N-OMCs with high surface area and ordered structure were used as a metal-free catalyst for oxygen reduction reaction (ORR), which exhibited much better electrocatalytic activity, long-term operation stability and high CH3OH tolerance compared to commercial Pt/C catalysts for ORR in alkaline fuel cell. Moreover, the influence of different amounts of nitrogen formed at different carbonization temperatures in N-OMCs on the ORR activity was researched. Honey as a nitrogen and carbon sources may be applied to various carbon materials for the development of other metal-free efficient materials for applications beyond fuel cells.

Macroporous carbon–graphene (MC–GR) composites were synthesized by a casting method using silica nanoparticles-graphene oxide (SiO2-GO) as the template and sucrose as the carbon precursor. The MC–GR composites combine the porous structure of MC with the excellent electrical and mechanical properties of GR. When used as a support for Pt electrocatalysts, Pt nanoparticles with an average diameter of 3.1 ± 0.7 nm are distributed onto the MC–GR. The MC on the surface of GR is beneficial for decreasing the aggregation of GR sheets and improving the diffusion of molecules through the GR sheets. Nonenzymatic amperometric sensor of glucose based on the Pt/MC–GR composites is developed. The Pt/MC–GR responds very rapidly to the changes in the level of glucose, producing steady-state signals within 3 s. Due to the low potential, no obvious interference is observed with the addition of ascorbic acid, acetaminophen, dopamine, and uric acid. The Pt/MC–GR also exhibits significant catalytic activity for the oxidation of methanol. The maximum peak value of oxidation current density at Pt/MC–GR is 81.6 mA mg−1, higher than that of Pt/GR (34.7 mA mg−1) and Pt/MC (65.8 mA mg−1).

We report a double pulse electrochemical method to controllably prepare silver nanocrystals (AgNCs) on graphene thin film electrode for fabricating a high performance H2O2 biosensor. The approach relies on two potential pulses that can independently control the nucleation and subsequent growth processes of AgNCs on graphene substrate. This method also allows the observation of AgNCs growing from a particle shape to a nanoplate form by increasing the growth time with the maximum lateral scale up to micrometer scale range. A proposed mechanism for these silver nanoplates (AgNPLs) formation was the oriented growth of small AgNCs and two-dimensional graphene template inducing effect. Such obtained graphene-AgNPLs hybrid thin films exhibit remarkable electrocatalytical activity toward H2O2 electrochemical reduction. Further fabricated nonenzymatic H2O2 biosensor displays a fast amperometric response time of less than 2s and a good linear range from 2 x 10(-5) M to 1 x 10(-2) M with an estimated detection limit of 3 x 10(-6) M. This biosensor also exhibits good stability (RSD, 13%), and high sensitivity of 183.5 mu A cm(-2) mM(-1) as well as high selectivity. The results show that this powerful double pulse potential electrochemical method could enable new opportunities in controllable preparation of multifarious nanomaterials on graphene substrate for their future applications. (C) 2012 Elsevier Ltd. All rights reserved.

Mesoporous carbon nanofibers (M-CNF) were synthesized using a self-templating strategy and a solution growth process. An M-CNF modified glassy carbon electrode (M-CNF/GCE) was fabricated, and its electrocatalytic performance was investigated for the first time using dopamine (DA), ascorbic acid (AA) and uric acid (UA) as probes. The M-CNF/GCE exhibited satisfactory electrocatalytic activity by significantly decreasing the oxidation potentials and increasing the peak currents in the oxidation of DA, AA and UA when compared with those obtained using the GCE. More importantly, the M-CNF/GCE afforded the simultaneous detection of DA, AA and UA at a physiological pH of 7.4 with a wide linear response and high sensitivity. Moreover, under amperometric conditions, the M-CNF/GCE was capable of detecting DA, AA and UA with low detection limits. Furthermore, the universality of the electrocatalytic capability of the M-CNF was confirmed by its superior electrocatalytic oxidation of purines, such as guanine (G), adenine (A), xanthine (XA) and hypoxanthine (HX).

A novel material based on cupric(II) oxide/macroporous carbon nanocomposites (CuO/MPC) has been prepared through a simple hydrothermal process. In the process of synthesis, the incorporation of MPC leads to a well-dispersed CuO nanoneedles on the surface of MPC. The new composite material combined the unique property of CuO and MPC, showed improved electrochemical activity towards H2O2 reduction and glucose oxidation. Based on the improved electrochemical property of CuO/MPC modified electrode, it can be used as sensor for the determination of H2O2 and glucose. In addition, the CuO/MPC modified electrode displayed good stability and antifouling features towards glucose oxidation. These results also indicate that CuO/MPC nanocomposites have of wide application foreground.

In this work, a comparative study on the electrocatalytic activities of ordered mesoporous carbons (OMCs) and graphene (GR) is presented. Using voltammetry and amperometry as detection methods, four DNA bases, double-stranded DNA (dsDNA), six important electroactive compounds and various biomolecules were employed to investigate their electrochemical responses on OMC and GR modified glassy carbon electrodes (OMC/GCE and GR/GCE). The results show that OMC/GCE enhances the electron transfer kinetics of these compounds compared to GR/GCE. The discrepancy in electrochemical activities can be attributed to the different microstructures of OMC and GR, which were examined by transmission electron microscopy, X-ray photoelectron spectra, X-ray diffraction, Raman spectra and nitrogen adsorption–desorption.

A simple hydrothermal synthesis of nickel hydroxide–ordered mesoporous carbons nanocomposites (Ni(OH) 2 –OMCs) is proposed for the first time. The characterization of the new material shows that, after anchoring Ni(OH) 2 nanoparticles on the mesoporous, ordered mesostructure of the nanocomposites remain intact and Ni(OH) 2 is electrochemically accessible. The performance of Ni(OH) 2 –OMCs is compared to OMCs and the properties of the new material are found to be improved. A sensor for sensitive detection of underivatized glycine has been developed based on Ni(OH) 2 –OMCs modified glass carbon (Ni(OH) 2 –OMCs/GC) electrode. The linear response of glycine measurement was up to about 3.2 mM with a high sensitivity of 10.5 μA mM −1 for the Ni(OH) 2 –OMCs/GC electrode. The detection limits was estimated to be 0.26 μM (S/N = 3). Then ethanol was selected as another marked molecule, a nonenzymatic amperometric sensor of ethanol based on the Ni(OH) 2 –OMCs nanocomposites is also constructed. The linear response of ethanol measurement was up to about 80 mM with a sensitivity of 0.65 μA mM −1 . The detection limits was estimated to be 4.77 μM (S/N = 3).

Ordered mesoporous carbon (OMC) was treated with HNO 3 or NaOH. The two treated OMCs have many oxygen-containing functional groups. Those treated with HNO 3 have more acidic surface groups than those treated with NaOH. Nicotinamide adenine dinucleotide (NADH) and H 2 O 2 were selected as marker molecules for the comparison of the electrocatalytic property of the OMCs. A comparison between the cyclic voltammograms shows that the oxidation peak potential of NADH is 0.614 V at a bare glassy carbon electrode (GCE), 0.205 V at OMC/GCE, 0.223 V at NaOH-treated OMC/GCE, and 0.0 V at HNO 3 -treated OMC/GCE (vs. Ag/AgCl). The results indicate that the HNO 3 -treated OMC/GCE exhibits the highest electrocatalytic activity for NADH oxidation. Thus, acidic groups rather than other oxygen-containing functional groups, play a very important role in the catalytic activity of OMC.

A novel composite film which contains ordered mesoporous carbon (OMC) along with the incorporation of poly(neutral red) (PNR) has been synthesized on glassy carbon electrode by potentiostatic method. This composite film was characterized by scanning electron microscope (SEM) and cyclic voltammetry (CV). Two pairs of the redox peaks appear at formal potential E 0′ = +0.045 V (peak I) and E 0′ = −0.49 V (peak II) at the PNR/OMC/GC electrode. And it is found that only the redox waves (peak I) exhibits good electrocatalytic activity towards nicotinamide adenine dinucleotide (NADH) and 2-mercaptoethanol (2-ME). Under a lower operation potential of +0.07 V, amperometry method was used to determine the concentration of NADH and 2-ME, respectively. In pH 7.0, sensors for two molecules under their corresponding optimized conditions were developed with acceptable sensitivity and low detection limits in large determination ranges. In addition, these sensors have good reproducibility and stability.

In this work, a novel structured Cerium (III) 12-tungstophosphoric acid (CePW)/ordered mesoporous carbon (OMC) composite is synthesized. The characterization of the material by the Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and electrochemical characterization shows that the novel CePW/OMC composite has improved properties based on the combination of CePW and OMC properties. CePW/OMC can be used to modify the glassy carbon (GC) electrode and the CePW/OMC/GC modified electrode shows an enhanced electrocatalytic activity. This property can be applied in the determination of some biomolecules. Especially, the detection and determination of the guanine (G) in the presence of adenine (A) is achieved. The catalytic current of G versus its concentration shows a good linearity with two good linear ranges from 4.0 × 10 −6 to 8.0 × 10 −5 M and from 8.0 × 10 −5 to 1.9 × 10 −3 M (correlation coefficient = 0.999 and 0.996) with a detection limit of 5.7 × 10 −9 M (S/N = 3). The linear range for adenine is 4.0 × 10 −6 –7.0 × 10 −4 M with a detection limit of 7.45 × 10 −8 M. With good stability and reproducibility, the present CePW/OMC/GC modified electrode should be a good model for constructing a novel and promising electrochemical sensing platform for further electrochemical detection of other biomolecules.

In the paper, a novel ordered mesoporous carbon/cobalt oxide nanocomposite (OMC–Co) was easily synthesized. After encapsulating cobalt oxide nanoparticles in the wall of the ordered mesoporous carbon (OMC), the mesostructure of the nanocomposite material remained highly ordered and intact. For the first time, OMC–Co material was used to modify the glassy carbon (GC) electrode, and the obtained OMC–Co/GC modified electrode showed strong electrocatalytic properties towards glutathione (GSH). The use of OMC–Co film to mediate the GSH oxidation exhibited remarkably strong and stable electrocatalytic response compared to that seen at OMC/GC electrode. These results showed that the electrocatalytic properties of OMC could be improved when the cobalt oxide nanoparticles were incorporated into this new material. A sensitive GSH sensor was developed based on the OMC–Co/GC electrode, which showed a high sensitivity and a remarkably low detection limit. Moreover, OMC–Co/GC modified electrode can be used for selective amperometric determination of GSH in the presence of glucose, dopamine (DA) and uric acid (UA).

This work reports effects of ferrocene derivative on the properties of an ordered mesoporous carbon (OMC). A novel method for the incorporation of iron oxide species in the carbon framework of OMC without any decrease in the surface area is also reported. The decomposition of ferrocene derivative yields iron species that facilitate the formation of the carbon framework. The performance of ordered mesoporous carbon containing iron oxide (OMC-Fe) is compared to OMC and the properties of the new material are found to be improved. OMC-Fe combines electrochemical properties of OMC and iron oxide species. Electrocatalytic properties towards H2O2 are enhanced because of synergetic effect of ordered mesoporous carbon and iron oxide species. The electrochemical determination of H2O2 at the OMC-Fe modified electrode is more sensitive than that at OMC electrode. A sensitive and stable H2O2 sensor was developed based on OMC-Fe electrode with a large determination range and a good reproducibility.

A stable suspension of ordered mesoporous carbon (OMC) was obtained by dispersing OMC in a solution of Nafion. By coating the suspension onto glassy carbon (GC) electrode, cyclic voltammetry was used to evaluate the electrochemical behaviors of Nafion-OMC-modified GC (Nafion-OMC/GC) electrode in 0.1 mmol L −1 hexaammineruthenium(III) chloride (Ru(NH 3 ) 6 Cl 3 )/0.1 mol L −1 KCl solution, where Nafion-OMC/GC electrode shows a faster electron transfer rate as compared with OMC/GC, Nafion/GC and GC electrodes. Due to the unique properties of Nafion-OMC, an obvious decrease in the overvoltage of the epinephrine (EP) oxidation (ca. 100 mV at pH 4.1 and 115 mV at pH 7.0) as well as a dramatic increase in the peak current (12 times at pH 4.1 and 6 times at pH 7.0) was observed at Nafion-OMC/GC electrode compared to that seen at GC electrode. By combining the advantages of OMC with those of Nafion, the anodic peak of EP and that of ascorbic acid (AA) were separated successfully (by ca. 144–270 mV) in the pH range of 2.0–10.0, which may make Nafion-OMC/GC electrode potential for selective determination of EP in the presence of AA at a broad pH range. As an EP sensor, the EP amperometric response at Nafion-OMC/GC electrode in pH 7.0 PBS is extremely stable, with 99% of the initial activity remaining (compared to 32% at GC surface) after 120 min stirring of 0.20 mmol L −1 EP. And Nafion-OMC/GC electrode can be used to readily detect the physiological concentration of EP at pH 7.0. These make Nafion-OMC/GC electrode potential candidates for stable and efficient electrochemical sensor for the detection of EP. The solubilization of OMC by Nafion may provide a route to more precise manipulation, and functionalization for the construction of OMC-based sensors, as well as allowing OMC to be introduced to biologically relevant systems.