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A new nanocomposite based on ruthenium nanoparticles (RuNPs) uniformly designed at chemically treated graphene oxide nanosheets (CTGONS) was prepared as active electrode for simultaneously sensing of dopamine (DA) and acetaminophen (AC) in the presence of high concentration of ascorbic acid (AA). The RuNPs actively decorates the CTGONS with uniform dispersion like pump sputtering of paints. The CTGONS of hexagonal nanosheets, 2D orientation, chemically treated to the reduced forms and active decoration by RuNPs lead to formation of high catalytic active sites and high loading of targets at the electrode surface. The suitable accommodation of RuNPs/CTGONS to fast response of targets ascertains a high catalytic activity, and fast charge transport. The RuNPs/CTGONS nanocomposite shows an obvious catalytic oxidation signal for DA and AC. The highly sensitive and selective electrode was designed based on RuNPs/CTGONS due to the large peak potentials separation of DA to AC of 0.22 V with sufficient electron mediating behavior. Moreover, the nanocomposite electrode shows individual and simultaneous determination of DA and AC with linear calibration plots from 5–120 μM and 10–120 μM, where their detection limits were calculated to be 0.018±0.002 and 0.023±0.003 μM, respectively. Finally, the analytical application of the RuNPs/CTGONS electrode was applied for the determination of DA and AC in the serum of human blood. [ABSTRACT FROM AUTHOR]

A simple detection method of ascorbic acid (AA) through selective catalytic oxidation has been developed using a novel conducting polymer poly-3′-(2-aminopyrimidyl)-2,2′:5′,2'-terthiophene (pAPTT). The pAPTT electrode showed an excellent selectivity in facilitating the electron transfer of AA and blocked the interferences of cationic species due to the positively charged pAPTT film. This method proved to be effective in the determination of AA in the presence of various biological interfering species. The dynamic range of AA detection was from 10 to 200 µM and the detection limit was 1.4±0.06 µM. [ABSTRACT FROM AUTHOR]