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Glyceline, reline, or ethaline deep eutectic solvents and carbon black nanoparticles within a crosslinked chitosan film are investigated as glassy carbon electrode modifiers for the first time. The selected 5 mgmL-1 glyceline modified GCE was characterized by cyclic voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy. Simultaneous determination of acetaminophen and diclofenac by differential pulse adsorptive stripping voltammetry (DPAdSV) presented limits of detection of 2.6×10-8 and 5.2× 10-8 molL-1 for acetaminophen and diclofenac, respectively, in pharmaceutical and biological samples. The obtained results were compared with those obtained by HPLC at a confidence level of 95%. [ABSTRACT FROM AUTHOR]

In this work, a simple and highly selective voltammetric method was developed for the simultaneous determination of paracetamol (PCT) and codeine (COD) in pharmaceuticals and human body fluids employing a glassy carbon electrode modified with carbon black (CB) and nickel oxide nanoparticles (NiONPs) within a dihexadecylphosphate (DHP) film. Using square-wave voltammetry (SWV), a separation of ca. 550 mV between the oxidation peak potentials of PCT and COD was obtained. The simultaneous determination of PCT and COD presented a linear concentration range from 3.0 to 47.8 µmol L−1 for PCT and from 0.83 to 38.3 µmol L−1 for COD. [ABSTRACT FROM AUTHOR]