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1. [Modifying effect of antioxidants on the rate of lipid peroxidation in liver microsomes at early stages of diethylnitrosamine biotransformation].

Author

Pakhomov VIu, Artemova LG, and Shuliakovskaia TS

Subjects
Animals, Biotransformation, Cytochrome P-450 Enzyme System metabolism, Diethylnitrosamine toxicity, Drug Interactions, Free Radicals, Lethal Dose 50, Male, Methylcholanthrene pharmacology, Microsomes, Liver enzymology, NADP metabolism, Rats, Rats, Inbred Strains, Time Factors, Antioxidants pharmacology, Diethylnitrosamine pharmacokinetics, Lipid Peroxidation drug effects, Microsomes, Liver metabolism
Abstract

Lipid peroxidation and free radicals' generation were investigated in rats treated with carcinogenic diethylnitrosamine (DENA) after pretreatment with some antioxidants. It was shown that decreased generation of free radicals during DENA metabolism in rat liver microsomes after pretreatment of animals with antioxidants may be the cause of the protective action of these antioxidants against DENA toxicity. Lipid peroxidation was shown to be not a crucial reaction in the toxic effect of DENA.

Published
1988

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