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Experiments of mice and rats showed the ability of afobazole (1, 10, and 100 mg/kg, p.o.) upon single, 5-day combined, and 5-day preliminary administration to prevent or significantly decrease the clastogenic effects of the prooxidant agent dioxidine (100 and 300 mg/kg, i.p.) and the clastogenic and teratogenic effects of the alkylating agent cyclophosphamide (20 mg/kg, i.p.).

The chromosome aberration assay in the bone marrow cells of C57B1/6 mice showed that the new 2-mercaptobenzimidazole derivative afobazole(1-100 mg/kg) prevented manifestations of the clastogenic effects of dioxidine (100 mg/kg, i.p.) over a period of 24 h and reduced by 44-75% the cytogenetic effect of dioxidine (300 mg/kg, i.p.). The same doses of afobazole produced a statistically significant decrease in the cyclophosphamide (20 mg/kg, i.p.) damage over a period of 24 h. Afobazole showed no inherent mutagen activity and did not potentiate the effects of mutagens studied.