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3 results on '"Santos FPS"'

1. Molecular profile of patients with myelofibrosis: a 10-year experience.

Author

Dias LFS, Pereira CLM, Centurião NF, Nascimento JZMD, Ribeiro AAF, Hamerschlak N, Marques CP, Lima ACV, Costa LND, Silva AFD, Lima VJT, Kerbauy MN, Kerbauy LN, Arcuri LJ, Campregher PV, Rocha JDAD, Datoguia TS, and Santos FPS

Subjects
Humans, Retrospective Studies, Mutation, Prognosis, Primary Myelofibrosis genetics, Primary Myelofibrosis diagnosis, Primary Myelofibrosis therapy, Hematopoietic Stem Cell Transplantation adverse effects
Abstract

Objective: To analyze the karyotype test and myeloid panel with next-generation sequencing findings in patients with myelofibrosis, and to compare transplant characteristics in patients referred for bone marrow transplantation., Methods: Retrospective, single-center study with patients diagnosed with myelofibrosis treated at Hospital Israelita Albert Einstein between 2010 and 2020., Results: A total of 104 patients with myelofibrosis were examined. Patients who had not been submitted to tests in our service were excluded. The final sample comprised 69 patients. Of these 69, 56 were submitted to karyotyping and 22 to myeloid panel with next-generation sequencing. Karyotype was normal in 60% of the patients and altered in 40%. The prevalence of high-risk molecular mutations was higher in patients referred for bone marrow transplantation (100% versus 50%). The median follow-up of transplant patients was 2.4 years and the overall survival at 2 years was 80% (95%CI: 62-100%)., Conclusion: The molecular analysis enables estimating the patient's risk and thus instituting more aggressive treatment such as bone marrow transplant for patients at higher risk, being a relevant tool to guide therapy. Given the significance of molecular analysis for therapeutic decision-making in myelofibrosis, collection and disclosure of data on the prevalence of cytogenetic changes and findings of next-generation sequencing in affected patients is important.

Published
2023
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2. Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Elderly.

Author

Gonçalves SEAB, Ribeiro AAF, Hirose EY, Santos FPS, Ferreira FM, Koch LOM, Tanaka M, Souza MS, Souza PMR, Gonçalves TJM, and Pereira AZ

Subjects
Aged, Body Composition, Brazil, Comorbidity, Geriatric Assessment, Humans, Nutrition Assessment, Nutritional Status, Aging, Consensus, Hematologic Neoplasms therapy, Hematopoietic Stem Cell Transplantation, Transplantation Conditioning
Abstract

The Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Elderly was elaborated by nutritionists, nutrologists and hematologists physicians from 15 Brazilians reference centers in hematopoietic stem cell transplantation, in order to emphasize the importancy of nutritional status and the body composition during the treatment, as well as the main characteristics related to patient's nutritional assessment. Establishing the consensus, we intended to improve and standardize the nutritional therapy during the hematopoietic stem cell transplantation. The Consensus was approved by the Brazilian Society of Bone Marrow Transplantation.

Published
2019
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3. Successful treatment of post-transplant relapsed acute myeloid leukemia with FLT3 internal tandem duplication using the combination of induction chemotherapy, donor lymphocyte infusion, sorafenib and azacitidine. Report of three cases.

Author

Campregher PV, Mattos VRP, Salvino MA, Santos FPS, and Hamerschlak N

Subjects
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Combined Modality Therapy methods, Female, Humans, Leukemia, Myeloid, Acute genetics, Male, Middle Aged, Neoplasm Recurrence, Local therapy, Niacinamide administration & dosage, Recurrence, Sorafenib, Treatment Outcome, Antineoplastic Agents administration & dosage, Azacitidine administration & dosage, Induction Chemotherapy, Leukemia, Myeloid, Acute therapy, Lymphocyte Transfusion, Niacinamide analogs & derivatives, Phenylurea Compounds administration & dosage, fms-Like Tyrosine Kinase 3 genetics
Abstract

Acute myeloid leukemia is a hematopoietic stem cell neoplastic disease associated with high morbidity and mortality. The presence of FLT3 internal tandem duplication mutations leads to high rates of relapse and decreased overall survival. Patients with FLT3 internal tandem duplication are normally treated with hematopoietic stem cell transplantation in first complete remission. Nevertheless, the incidence of post-transplant relapse is considerable in this group of patients, and the management of this clinical condition is challenging. The report describes the outcomes of patients with FLT3 internal tandem duplication positive acute myeloid leukemia who relapsed after allogeneic hematopoietic stem cell transplantation and were treated with the combination of re-induction chemotherapy, donor lymphocyte infusion, sorafenib and azacitidine. Three cases are described and all patients achieved prolonged complete remission with the combined therapy. The combination of induction chemotherapy followed by donor lymphocyte infusion, and the maintenance with azacitidine and sorafenib can be effective approaches in the treatment of post-hematopoietic stem cell transplant and relapsed FLT3 internal tandem duplication positive acute myeloid leukemia patients. This strategy should be further explored in the context of clinical trials.

Published
2017
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