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The aim of this work is detection of the effect of PRP on wound healing on diabetic wound in ischemic patients, this study is randomized controlled clinical trial that was conducted on ( 30 ) patients who was divided in 2 groups; group (A) received PRP, and group (B) received the traditional dressing after revascularization of the previous ischemic diabetic limbs, both groups were divided randomly by randomization block at the department of Vascular and General surgery, Beni - Suef University Hospital. Results: There was no significant association between the both groups regarding the post-operative complication (p value; 0.698). There was significant strong inverted correlation between rate of healing and size of ulcers. And there was significant strong proportional correlation between size of ulcers and treatment time (p=0.002) and there was significant strong proportional correlation between size of ulcers and the number of injections (p=0.040). However, the cost of the PRP technique was much higher than the traditional technique and p value was statistically significant.