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Context Post-coronavirus disease 2019 (COVID-19) disease patients are immunocompromised, especially those who have a history of hospitalization during the COVID time and steroid use during hospitalization. Such patients are very susceptible to opportunistic infections and must be assessed proactively. Patients and methods This was a cross-sectional study on 125 post-COVID-19-positive patients 28 days after being COVID negative confirmed by an RT-PCR test. Sputum/bronchoalveolar lavage samples were taken for analysis. Statistical analysis used SPSS, version 20.0 was used for the analysis. A P value less than 0.05 was considered statistically significant. Results Out of 119 sputum samples assessed, 15 were AFB positive, and Mycobacterium tuberculosis (MTB) was detected in 16 patients by the GeneXpert assay, out of which 15 were sensitive to rifampicin and one was resistant. Bronchoalveolar lavage was performed in nine patients where two were found AFB-positive, and MTB was detected in two patients by the GeneXpert, out of which one was rifampicin sensitive and one was rifampicin resistant. Conclusions A significant portion of the world population has latent tuberculosis (TB) infection, and the COVID-19 disease may have led to an increase in the incidence of active TB. A proactive approach is needed for the diagnosis of TB and to control the spread of TB.

Amebic lung abscess without involving another system like liver or colon is immensely uncommon. We want to report a case of a 72-year-old woman who presented in emergency with complaints of shortness of breath, loss of weight, right-side chest pain, and loss of appetite since 6 months. Thorax and abdomen sonography showed right-side massive pleural effusion with no significant finding in the abdomen. In pleural fluid reports, amebic serology IgG by indirect immunofluorescence assay and serum PCR for amoeba came positive. The patient was diagnosed with primary amebic lung abscess. After 14 days of treatment, the patient showed no signs of improvement. Pleural tap was done again and came positive for malignant cells. With ultrasound guidance, pleural biopsy was done, and histopathological investigations showed adenocarcinoma. This case exhibited that repetitive cytological examination of pleural effusion and histopathological examination should be used in cases showing recurrent effusion or unusual conditions, like our patient.