The article deals with theoretical analysis of the indicators system concept, observes in details such components of this system as society, nature, economy. The general indicators of social, ecological, and economic system development are considered. It has been found that indicators are the indexes system of ecological, economical, and social development and give the possibility to analyze and control the implementation of areas sustainable development statement. The system of indicators, which characterize the level of the region stability on the basis of domestic and foreign experience considering region peculiarities, has been improved. At that, the regional peculiarities of both the natural and resource potential and the economical activity impact on the natural and resource potential have been taken into account.