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The Asia-Pacific region includes a majority of the world's population and many of its most rapidly growing economies. It is also home to the world's largest number of extremely poor people, many fragile states, and unsustainable environmental practices. The region has increased its influence in the world economy but is still grappling to overcome complex interrelated challenges of poverty, inequality and sustainable development. Its priorities must be addressed as a central element of any post-2015 global development goal framework. Drawing from lessons of the Millennium Development Goals, this paper suggests a conceptual framework to guide a new generation of goals, along with an intergovernmental approach to implementation. The “ZEN” framework stresses the distinct challenges of achieving zero extreme poverty (Z), setting country-specific “Epsilon” benchmarks for broader development challenges (E), and promoting environmental sustainability both within and across borders (N). [ABSTRACT FROM AUTHOR]