1. Assessment of tuberculosis disease activity in people infected with
- Author
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Inge, Kroidl, Mohamed I M, Ahmed, Sacha, Horn, Christina, Polyak, Allahna, Esber, Ajay, Parikh, Leigh Anne, Eller, Hannah, Kibuuka, Michael, Semwogerere, Betty, Mwesigwa, Prossy, Naluyima, Joy Mary, Kasumba, Jonah, Maswai, John, Owuoth, Valentine, Sing'oei, Eric, Rono, Rebecca, Loose, Michael, Hoelscher, Julie, Ake, and Christof, Geldmacher
- Abstract
Early detection of asymptomatic incipient tuberculosis (TB) could improve clinical outcomes and reduce the spread ofBetween Jan 1, 2013 and Aug 31, 2018, 2014 people living with HIV were screened annually for active TB using the Xpert MTB/RIF diagnostic assay in 11 clinics in Kenya, Tanzania, Uganda, and Nigeria. Longitudinal blood mononuclear cell samples from 46 selected patients with active and recurrent tuberculosis, latent infection, or incipient TB were further analysed forIn most cases, progression to active TB disease started 6-12 months before diagnosis by clinical symptoms and sputum occurrence of bacilli. Blood biomarkers could facilitate early detection of incipient TB, improve clinical outcomes, and reduce the transmission ofThis work was supported by the President's Emergency Plan for AIDS Relief via a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense [W81XWH-11-2-0174, W81XWH-18-2-0040] and by the Bundesministerium für Bildung und Forschung (BmBF) through funding of the Deutsches Zentrum für Infektionsforschung (DZIF, TTU-TB personalized medicine TTU 02_813).
- Published
- 2021