1. Virus kinetics and biochemical derangements among children with Ebolavirus disease
- Author
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Lindsey Kjaldgaard, Kasereka Masumbuko Claude, Daniel Mukadi-Bamuleka, Richard Kitenge-Omasumbu, Devika Dixit, François Edidi-Atani, Meris Matondo Kuamfumu, Junior Bulabula-Penge, Fabrice Mambu-Mbika, Olivier Tshiani-Mbaya, Janet Diaz, Sabue Mulangu, Anais Legand, Placide Mbala-Kingebeni, Pierre Formenty, Steve Ahuka-Mundeke, Jean-Jacques Muyembe-Tamfum, and Michael T. Hawkes
- Subjects
Ebolavirus disease ,Child ,Viral load ,Mortality ,Medicine (General) ,R5-920 - Abstract
Summary: Background: A paucity of data is available on virologic and biochemical characteristics of paediatric Ebolavirus disease (EVD), compared to adults. Methods: We conducted a retrospective chart review of children (7.6 log10copies/mL, alanine transaminase >525 U/L, C-reactive protein >100 mg/L, blood urea nitrogen >7.5 mmol/L, rhabdomyolysis, and.acute kidney injury. Interpretation: Paediatric EVD patients, like adults, experience multiorgan dysfunction with life-threatening electrolyte imbalances, hypoglycaemia, kidney injury, liver injury, and rhabdomyolysis. Paediatric patients have significantly higher VLs throughout the course of EVD than adults. Funding: This study was not funded.
- Published
- 2022
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