1. Mesenchymal stem/stromal cell-based therapy for the treatment of rheumatoid arthritis: An update on preclinical studies
- Author
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Mercedes Lopez-Santalla, Juan A. Bueren, and Marina I. Garin
- Subjects
Oncology ,ID, intradermal ,RANTES, regulated upon activation normal T cells expressed and presumably secreted ,AS, arthritis score ,RA, rheumatoid arthritis ,PPAR, peroxisome proliferator-activated receptor ,Etanercept ,TNF-α, tumour necrosis factor α ,Bzb, bortezomib ,iLNs, inguinal lymph nodes ,CXCR3, chemokine receptor 3-alternative ,BMZ, betamethasone ,Medicine ,CIA, collagen-induced arthritis ,PP, peyer's patch ,GIP, gastric inhibitory polypeptide ,D, days ,EVs, extracellular vesicles ,Mtx, methotrexate ,mAIA, antigen-induced arthritis in mouse ,MTC, Masson´s trichrome ,030220 oncology & carcinogenesis ,Rheumatoid arthritis ,CTLA4, cytotoxic T lymphocyte antigen ,iNOS, inducible nitric oxide synthase ,KC, keratinocyte chemo-attractant ,OCPs, osteoclast precursors ,MCP-1, monocyte chemotactic protein 1 ,PTPN22, protein tyrosine-phosphatase 22 ,medicine.medical_specialty ,rAIA, adjuvant-induced arthritis in rats ,MensMSCs, MSCs from menstrual fluid ,BM-MSCs, MSCs from bone marrow ,MIP-2, macrophage inflammatory protein 2 ,03 medical and health sciences ,R5-920 ,IP10, IFN-γ-induced protein 10 ,IM, intramuscular ,NRP-1, neuropilin-1 ,S, syngeneic ,ESR, erythrocyte sedimentation rate ,MPs, microparticles ,PBMCs, peripheral blood mononuclear cells ,AD, adipose tissue ,MVs, microvesicles ,P, placenta ,sCIA, collagen-induced arthritis in sheep ,Bregs, regulatory B cells ,X, xenogeneic ,Improvements in MSC-based therapy ,AD-MSCs, MSCs from adipose tissue ,030104 developmental biology ,TF, tissue factor ,Protocols ,Gilz, glucocorticoid-induced leucine zipper ,DM, dexamethasone ,STAT3, signal transducer and activator of transcription 3 ,ANA, Anti-nuclear antibodies ,SAA, serum amyloid-A ,ERDF, European Regional Development Fund ,µCT, micro computed tomography imaging ,Arthritis, Rheumatoid ,T-AOC, total antioxidant capacity ,rCIA, collagen-induced arthritis in rats ,ISCT, international society for cellular therapy ,NF-κB, nuclear factor-kappa B ,RORγT, retinoic acid-related orphan receptor ,TCR, T cell receptor ,OVAIA, ovalbumin-induced arthritis ,UC, umbilical cord ,CAIA, collagen-antibody induced arthritis ,Flk, tyrosine kinase receptor for vascular endothelial growth factor ,IDO, indoleamine 2,3-dioxygenase ,MMP, matrix metalloproteinase ,Tr1, IL-10-expressing T cells ,SM, synovial membrane ,medicine.anatomical_structure ,IAA, indoleacetic acid ,MPCs, mesenchymal precursor cells ,SNP, sodium nitroprusside ,medicine.drug ,NA, not available ,IL-1RA, IL-1 receptor antagonist ,CD, cluster of differentiation ,DMARDs, antirheumatic drugs ,TBO, toluidine blue O ,=, similar to or equal ,SM-MSCs, MSCs from synovial membrane ,Mesenchymal Stem Cell Transplantation ,PB, peripheral blood ,G, gingiva tissue ,IFA, incomplete Freund´s adjuvant ,OVA, ovalbumin ,MSCs, mesenchymal stem/ stromal cells ,SO, safranin ,TRAF, tumour necrosis factor receptor-associated factor ,Animals ,SP, spleen ,ILA, indole-3-lactic acid ,mBSA, methylated bovine serum albumin ,business.industry ,F, female ,SF, synovial fluid ,Th, T helper cells, TLR, toll-like receptors ,BM, bone marrow ,Bone marrow ,Synovial membrane ,MRI, magnetic resonance imaging ,WT, wild type ,Medicine (General) ,IHC, immunohistochemical analysis ,Review ,miR, microRNA ,TRACP, tartrate-resistant acid phosphatase ,AAV, adeno-associated virus ,0302 clinical medicine ,GSH, glutathione ,SVF, stromal vascular fraction ,H/E, haematoxylin/eosin staining ,GITR, glucocorticoid-induced tumour necrosis factor receptor ,pLNs, popliteal lymph nodes ,FOXP3 ,General Medicine ,IFI, indirect immunofluorescence ,Tregs, regulatory T cells ,M, male ,RF, rheumatoid factor, RNA, ribonucleic acid ,TNFR, tumour necrosis factor receptor ,<, worse than ,IP, intraperitoneal ,NuMa, nuclear mitotic apparatus ,COMP, cartilage oligomeric matrix protein ,GSH-Px, glutathione peroxidase ,%2C+better+than%22">>, better than ,LP, lamina propria, LPS, lipopolysaccharide ,IN, intranodal ,AT, antithrombin ,General Biochemistry, Genetics and Molecular Biology ,CM, conditioned medium ,Consec., consecutive ,RAGE, receptor for advanced glycation products ,ETN, etanercept ,Humans ,dLNs, draining lymph nodes ,MDA, malondialdehyde ,IFN-γ, interferon gamma ,ALP, alkaline phosphatase ,HSCs, hematopoietic stem cells ,Mesenchymal stem cell ,Mesenchymal Stem Cells ,medicine.disease ,EMA, European medicine agency ,IL, interleukin ,CFA, Freund's complete adjuvant ,DAB, 3,3´-diaminobenzidine ,OPG, osteoprotegerin ,HMGB-1, high-mobility group box-1 ,CRP, C reactive protein ,Tol-DCs, tolerogenic dendritic cells ,0301 basic medicine ,CII, collagen II ,SF-MSCs, MSCs from synovial fluid ,MPO, myeloperoxidease ,A, allogeneic ,LDL, low density lipoprotein ,APCP, α, β methylene selective A2A adenosine receptor competitive antagonist (CD73 inhibitor) ,Translational Research, Biomedical ,SSEA, severe spontaneous erosive arthritis ,mLNs, mesenteric lymph nodes ,PGIA, proteoglycan-induced arthritis ,Exos, small vesicles/Exosomes ,FOXP3, forkhead box P3 ,RANKL, receptor activator of nuclear factor κB ligand ,TGF-β, transforming growth factor β ,Stromal vascular fraction ,NSAIDs, non-steroidal anti-inflammatory drugs ,VEGF, vascular endothelial growth factor ,Animal models ,AhR, aryl hydrocarbon receptor ,DCs, dendritic cells ,IV, intravenous ,Stromal cell ,IA, intra-articular ,SIRT1, sirtuin 1 ,O-MSCs, MSCs from nasal tissue ,PA, peri-articular ,Tfh, follicular T helper cells ,AxLNs, axillar lymph nodes ,NK, natural killer cells ,T-MSCs, MSCs from tonsil tissue ,SOD, superoxide dismutase ,Internal medicine ,MHC, major histocompatibility complex ,GLP-1, glucagon-like peptide 1 ,G-MSCs, MSCs from gingiva tissue ,Mesenchymal stem/stromal cells ,PG, proteoglycan ,HLA-II, human leukocyte antigen-II ,PLGA, poly-lactic-co-glycolic acid ,HDL, high density lipoprotein ,Ig, immunoglobulin ,SC, subcutaneous ,P-MSCs, MSCs from placenta tissue, POM-1, sodium polyoxotungstate (CD39 inhibitor) ,UC-MSCs, MSCs from umbilical cord ,business ,sIL6R, soluble IL-6 receptor - Abstract
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and progressive joint destruction and is a primary cause of disability worldwide. Despite the existence of numerous anti-rheumatic drugs, a significant number of patients with RA do not respond or are intolerant to current treatments. Mesenchymal stem/stromal cell (MSCs) therapy represents a promising therapeutic tool to treat RA, mainly attributable to the immunomodulatory effects of these cells. This review comprises a comprehensive analysis of the scientific literature related to preclinical studies of MSC-based therapy in RA to analyse key aspects of current protocols as well as novel approaches which aim to improve the efficacy of MSC-based therapy.
- Published
- 2021
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