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Acceleration of raw materials’ depletion and waste accumulation create a need for stakeholders to shift from linear to circular business models by adopting novel strategies. Circular economy (CE) and industrial symbiosis (IS) offer a direction towards sustainable, resource efficient systems and eco-friendly waste management approaches. IS encompasses all types of interfirm cooperation in order to achieve a green, waste-free supply chain and at the same time to attain profits. However, among other barriers hampering widespread adoption of IS is lack of information exchange. Digital tools have emerged as facilitators of IS, since they enable real-time data sharing, identification and evaluation of symbiotic opportunities, while continuous progress of those tools is necessary for the digital transformation of IS. Important elements for the functionality and success of such tools are the criteria determining the matching of potential stakeholders and the support of the decision-making process. In the ongoing research that is presented, these matching criteria and benchmarks for waste valorization pathways are investigated and a matchmaking framework is proposed. The objective of the framework is to identify the most suitable collaborators to be deployed later to an automated matchmaking process, revealing latent possibilities (e.g. by suggesting indirect matches) and advantages of symbiotic actions from a holistic perspective. This tailor-made assessment is aspired to evaluate stakeholders’ compatibility based on more than a mere waste streams’ valorization match. Stakeholders’ specific requirements and motivations are incorporated in the potential partnership evaluation, thereby a multicriterion approach is proposed considering the potential cooperators’ relevance in terms of aspects like strategic goals, the level of IS embracement or synergy’s environmental impact.