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The article presents the results of experimental studies of LED degradation in greenhouse irradiators for horticulture. It was found that in the process of operation of the irradiators the emission spectrum changes. This is caused by different decrease rate of photosynthetic photon flux of different colored LEDs. For a longer service life it is recommended to use greenhouse irradiators with a large proportion of red LEDs.

The influence of biologically active compounds on the functional state of the central nervous system and the emotional component in rats can be evaluated by using behavioral methods, which are based on studying the exploratory behavior of animals in an environment new to them. One such method is the study of animal behavior in an elevated cross-shaped maze with open and closed arms and the Porsolt "despair" test. The aim of our study was to investigate the emotional state of the offspring of rats treated with aqueous plant extracts of Centella asiatica, Ginkgo biloba, Eleuterococcus and a mixture of aqueous extracts of Centella asiatica and Ginkgo biloba. The study of the emotional state of the offspring of rats treated with aqueous plant extracts was performed on 3 month old animals obtained in the experiment from males (20 animals) and females (50 animals), which received aqueous plant extracts at a dose of 30 mg/100 g of the animal body weight, in the volume of 1 ml for 30 days. Conclusions: Aqueous extracts of Centella asiatica, Ginkgo biloba and Eleutherococcus have pronounced nootropic activity, as the evaluation of animal anxiety level in the Elevated Cross Maze test and depression level in the Porsolt Despair Behavior test show a significant difference in the behavior of intact rats and offspring rats, receiving aqueous plant extracts as an additional load and the most pronounced effect is observed with the complex application of extracts of Centella asiatica and Ginkgo biloba.

The COVID-19 pandemic has brought severe demographical, socioeconomic, and territorial impacts. Those challenges require the world community to develop both response measures and anticipation of new threats. Therefore, creating the modern tools to forecast various indicators of the impact intensity pandemic becomes important and relevant for consideration and evaluation of interregional differences. This paper presents deep neural network models to predict a viral pandemic's effects in the regional cluster of Moscow and its neighbors. They are based on recurrent and Transformer-like architectures and utilize the attention mechanism to consider the features of the neighbor regions and dependencies between various indicators. These models are trained on heterogeneous data, including daily cases and deaths, the diseased age structure, transport, and hospital availability of the regions. The experimental evaluation shows that the demographic and healthcare features can significantly improve the accuracy of economic impact prediction. We also revealed that the neighboring regions' data helps predict the outburst's healthcare and economic impact. Namely, that data helps to improve accuracy for both the number of infected and the unemployment rate. The impact forecasting would help to develop strategies to reduce inter-territorial inequality due to the pandemic.

Hemato-ophthalmic barrier protects nervous system tissues from adverse factors. Against the background of inflammatory process caused by mechanical trauma of the eye, large molecules are able to penetrate the eyeball. At present, the mechanism of restoring the homeostatic balance of the body under oxidative stress caused by mechanical trauma of the eye is poorly studied. The aim of the study was to study the dynamics of catalase activity in rat brain tissue under oxidative stress caused by mechanical influence on hemato-ophthalmic barrier. Materials and methods: the study was conducted on white male rats of six months of age in the amount of 150 pieces. The activity of catalase in brain tissue was studied before the experiment, as well as on the 1st, 3rd, 5th, 7th and 14th day of the experiment using the standard Korolyuk M.A. method. The obtained digital material was statistically processed by non-parametric statistical analysis. Conclusion: The activity of catalase in the rat brain under oxidative stress caused by mechanical action on the hemato-ophthalmic barrier is most effectively stabilized in the standard therapy of mechanical eye injury with the addition of quercetin in the form of injections.

Hemato-ophthalmic barrier is one of the mechanisms of body resistance. One of the complications of mechanical trauma of the eye and violation of the hemato-ophthalmic barrier is the emergence of oxidative stress on the background of the general inflammatory process. Normally, oxidative stress in the skeletal muscle tissue is not a damaging agent, but when intensified by other factors, it promotes pathological changes in the body. Objective: to study the dynamics of superoxiddismutase (SOD) activity in rat skeletal muscle tissue under oxidative stress caused by mechanical action on the hemato-ophthalmic barrier. Materials and methods: The study was carried out on pedigree matured male rats in the amount of 150 pieces. The activity of SOD in skeletal muscle tissue was studied before the experiment, as well as on the 1st, 3rd, 5th, 7th and 14th day of the experiment using the standard technique of V.S. Gurevich. The obtained digital material was subjected to statistical processing by means of non-parametric statistical analysis. Conclusion: SOD activity in rat skeletal muscle tissue under oxidative stress caused by mechanical action on hemato-ophthalmic barrier is most effectively stabilized in standard therapy of mechanical eye injury with the addition of quercetin in the form of injections.

To reduce environmental tension the development of Kuzbass ecological culture is of great importance. Its most significant component is environmental education, in general, and the training of mining engineers with high level of ecological education, in particular. The presence of environmental education in the field of nature management cannot yet become a guarantor of environmental problems solution. It should be embodied in the behavior of a person, in the image of his life, in the system of values, in his ecological worldview. Educational reforms have become a response to the challenges posed by the social-and-economic development to the personality of a specialist, including the personality of a mining engineer in Russia and its regions. To identify the features of environmental education in the transition to the sustainable development it is important to set the main links in the system of continuous education and their peculiarities, which radically change the quality of training of mining engineers and the demand for specialists in the labor market.