1. The effect of salinomycin on the immune response of chicks.
- Author
-
Shalaby MA, el-Sanousi AA, Yehia MM, Naser A, and Reda IM
- Subjects
- Animals, Antibodies, Viral biosynthesis, Immunity, Cellular drug effects, Male, Newcastle disease virus immunology, Viral Vaccines immunology, Chickens immunology, Coccidiostats pharmacology, Immune System drug effects, Pyrans pharmacology
- Abstract
The effect of salinomycin drug on the immune system of chickens was investigated. By using the recommended dose 60 mg/kg feed salinomycin was given as anticoccidial drug continuously for 49 days. There was no noticeable significant effect on the humoral and cell-mediated immune responses to Newcastle Disease Virus (NDV) Vaccine. A drastic immunosuppressive effect was manifested by using a dose of 120 mg/kg and characterized by lowered titers of antibodies to NDV, decrease in the relative weight of lymphoid organs, lowered mitogenic response of peripheral blood lymphocytes (PBL) to phytohaemagglutinin (PHA) with reduction of heterophils percentage, as well as reduced protection rate to intramuscular challenge with the velogenic viscerotropic (VV) strain of NDV.
- Published
- 1993