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Researchers from the University of California San Francisco (UCSF) have conducted a study on Alzheimer's disease and tauopathies, which are neurodegenerative conditions characterized by the accumulation of abnormal tau protein. The researchers found that caspase-6, an enzyme involved in cell death, can cleave tau protein and contribute to its neurotoxicity and aggregation. They also discovered that caspase-cleaved tau may be a more accurate biomarker for these conditions compared to conventional phospho-tau antibodies. The study suggests that developing caspase-6 inhibitors could be a potential therapeutic strategy for tauopathies. [Extracted from the article]

A study conducted at Hashemite University in Zarqa, Jordan, examined the neurotoxic effects of imidacloprid (IMI), a commonly used pesticide, and the potential neuroprotective effect of berberine chloride loaded nano-PEGylated liposomes (Ber-Lip). The study found that oral administration of IMI resulted in cerebellar histopathological alterations, oxidative stress, and the upregulation of markers associated with neurodegenerative disorders and Alzheimer's disease. However, treatment with Ber-Lip reduced these effects and improved histopathological and ultrastructure alterations. The study highlights the neurotoxic effects of IMI and the potential neuroprotective effects of Ber-Lip. [Extracted from the article]

A recent study conducted at Hunan University of Chinese Medicine in Changsha, China, has developed a new electrochemical method for detecting caspase-3, a protein involved in apoptosis. The researchers used metal-organic frameworks (MOFs) loaded with methylene blue (MB) as signal reporters. The study found that caspase-3 could be accurately detected with a linear range from 0.1 to 25 pg/mL and a limit of detection down to 0.04 pg/mL. This method has potential applications in apoptosis-related diagnosis and the screening of caspase-targeting drugs. [Extracted from the article]

Researchers at Mahidol University in Bangkok, Thailand have conducted a study on potential drug-like dual inhibitors of trypanosomal cruzain and rhodesain cysteine proteases. Through virtual screening and molecular dynamics simulations, they identified two nitrogenous heterocyclic molecules with promising inhibitory properties. The molecules were found to occupy the binding sites and stabilize the protease complexes. The researchers also conducted ADMET predictions, which indicated favorable pharmacokinetic profiles and adequate oral bioavailability for the molecules. This research has been peer-reviewed and provides valuable insights for drug development in the field of life science. [Extracted from the article]

Researchers from Maynooth University have developed a novel ratiometric fluorescent probe, Ac-DEVD-PABC-Naph, for detecting caspase-3 activity, an enzyme involved in apoptosis. The probe utilizes a 1,8-naphthalimide fluorophore linked to a peptide sequence, and upon cleavage by caspase-3, it releases the free fluorophore, resulting in a change in fluorescence emission. The probe demonstrated high sensitivity and selectivity for caspase-3, making it a promising tool for visualizing caspase-3 activity in biological systems and potentially aiding in apoptosis research and drug development. The research was supported by Science Foundation Ireland. [Extracted from the article]

Researchers from the National Health Research Institution in Zhunan, Taiwan have developed a potential treatment for Alzheimer's disease (AD) using a cysteine protease inhibitor called CT001. The inhibitor was encapsulated in microspheres and demonstrated anti-inflammatory properties, reduced CTSS expression, and improved learning and memory in AD mice. The study suggests that CT001 delivered via these microspheres could be a promising approach for managing AD in patients. The research was supported by the National Health Research Institutes in Taiwan and has been peer-reviewed. [Extracted from the article]

A recent study conducted by researchers from Mahidol University in Thailand explored the anti-cancer activity of Diospyros rhodocalyx Kurz, a traditional Thai medicine, against prostate cancer. The study found that the ethyl acetate extract of D. rhodocalyx Kurz exhibited a dose-dependent cytotoxic effect on LNCaP human prostate cancer cells, inducing apoptosis. The extract upregulated pro-apoptotic BAX, downregulated anti-apoptotic Bcl-2, and activated caspase-3, leading to apoptosis. The presence of epilupeol, a major compound in the extract, suggests its potential as a therapeutic agent for prostate cancer. [Extracted from the article]

A recent study conducted at Washington State University has investigated the interaction between the intracellular bacteria Coxiella burnetii and immune signaling. The researchers focused on the role of caspase-8, a regulator of cell death pathways, in C. burnetii infection. They found that C. burnetii inhibits caspase-8, leading to decreased apoptosis and increased susceptibility to necroptosis. The study suggests that caspase-8 plays a key role in regulating C. burnetii infection and may present new therapeutic opportunities. [Extracted from the article]

A study conducted by researchers at Nanjing University of Chinese Medicine has found that Liguzinediol (Lig) has potential in mitigating Doxorubicin (DOX)-induced cardiotoxicity, a side effect of the widely used antineoplastic drug DOX. The study explored the effects and mechanisms of Lig's protective role against DOX-induced cardiotoxicity. The results showed that Lig effectively countered oxidative stress, improved cardiac function, and attenuated myocardial cell apoptosis. The study concluded that Lig could be a natural product with therapeutic potential for preventing DOX-associated cardiac complications. [Extracted from the article]

Researchers at Islamia University Bahawalpur in Pakistan have conducted a study on Effector Caspases, specifically focusing on N-(4-acetyl-4,5-dihydro-5-(7,8,9-substituted-tetrazolo[1,5-a] acetamides of -quinolin-4-yl)-1,3,4-thiadiazol-2-yl) derivatives. These derivatives have shown potential as anticancer agents against a human cervical cancer cell line. The study utilized computational analysis, molecular docking, ADMET studies, and molecular dynamics simulations to assess the binding interactions, safety profiles, and potential of these derivatives as caspase-3 inhibitors. The research identified derivative 4e as a lead candidate for a more powerful caspase-3 inhibitor in tumors with high levels of caspase-3. The study has been peer-reviewed and published in Structural Chemistry. [Extracted from the article]

A recent study conducted at a British university examined the effects of copper oxide nanoparticles (CuO-NPs) on the submandibular salivary gland in albino rats. The study found that CuO-NPs caused significant cytotoxic effects on the gland cells, leading to increased levels of Ki-67 and caspase-3. However, when the rats were treated with a combination of CuO-NPs and vitamin C (VC), the toxic effects were mitigated, suggesting that VC may have antioxidant properties. This research provides valuable insights into the potential benefits of VC therapy in counteracting the toxicity of nanoparticles. [Extracted from the article]

A recent study conducted at Zhejiang Chinese Medicine University in Hangzhou, China, has explored the potential of a small molecule called CZL80 in terminating refractory status epilepticus (SE), a serious and life-threatening medical emergency characterized by prolonged seizures. The study found that CZL80, which inhibits caspase-1, effectively terminated diazepam-resistant SE and extended the therapeutic time window for treatment. The researchers also discovered that CZL80 blocked glutamatergic transmission, providing a potential therapeutic approach for refractory SE. This research has important implications for the clinical treatment of SE. [Extracted from the article]

Researchers from Nanjing University have published new findings on sepsis-induced acute kidney injury (AKI) in the journal Cell Communication and Signaling. The study focuses on the role of acetyl-CoA synthetase 2 (ACSS2) in regulating pyroptosis and inflammation in renal epithelial tubular cells (RTECs) during AKI. The researchers found that ACSS2 upregulates the KLF5/NF-kB pathway, leading to NLRP3-mediated caspase-1 activation and pyroptosis in RTECs. These findings suggest that ACSS2 could be a potential therapeutic target for AKI. The study provides valuable insights into the pathogenesis of sepsis-induced AKI and highlights the importance of understanding the molecular mechanisms underlying this condition. [Extracted from the article]

A recent study conducted by researchers at the University of South Alabama School of Medicine has identified new indicators of sepsis and organ injury. The study found that amyloid-b (Ab) and caspase-1 are key innate immune mediators that play a role in defining sepsis outcomes. Plasma caspase-1 levels were found to be the best predictor of sepsis in ICU patients, and Abx-40, a specific isoform of amyloid-b, was associated with organ injury. These findings suggest that Abx-40 and caspase-1 could serve as early indicators of sepsis and its associated complications. [Extracted from the article]

A recent study conducted at Ningbo Yinzhou Second Hospital in Zhejiang, China, explored the effects of propofol anesthesia on pyroptosis in the neonatal rat hippocampus. The researchers found that propofol anesthesia may trigger inflammatory responses by activating the nod-like receptor protein 3/caspase-1 pathway, leading to pyroptosis and reduced learning and memory performance. The study suggests a potential link between propofol anesthesia and cognitive impairment in neonatal rats. Further research is needed to fully understand the implications of these findings. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the role of caspase-8 in the interaction between the intracellular bacteria Coxiella burnetii and the immune system. The study found that C. burnetii inhibits caspase-8, leading to decreased apoptosis and increased susceptibility to necroptosis. The researchers also observed that C. burnetii replication was increased in cells lacking caspase-8, which was associated with decreased TNF production and reduced cell death. This research suggests that caspase-8 plays a key role in regulating C. burnetii infection and may provide new avenues for therapeutic interventions. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

A recent study conducted by researchers from the University of Virginia Health System explores potential nonantibiotic-based treatment strategies for Clostridioides difficile infection. The study focuses on the role of a survival-signaling pathway in protecting against the virulent factor, C. difficile toxin B (TcdB), which is essential for causing disease. The researchers found that activation of the MIF-CD74-Akt prosurvival signaling pathway blocked TcdB-induced caspase-3 activity and intestinal epithelial cell death. This study provides proof-of-concept for a unique antibiotic-independent strategy for protecting against C. difficile toxin-mediated cell death. [Extracted from the article]

A recent study conducted by researchers from Zhejiang Chinese Medicine University in China explored the potential therapeutic effects of Tetrastigma hemsleyanum (Sanyeqing) on febrile seizures (FS). The study found that T. hemsleyanum exhibited anticonvulsant effects by inhibiting neuroinflammation and regulating the PKC-d/caspase-1 signaling pathway. The research involved various methods such as hot bath models, magnetoencephalography, UPLC-MS/MS analysis, metabonomics, transcriptomics, and network pharmacology. The findings suggest that T. hemsleyanum could be a potential treatment for FS, but further research is needed to fully understand its mechanism of action. [Extracted from the article]

A recent report from Cincinnati Children's Hospital discusses research on acute myeloid leukemia (AML). The study focuses on the role of Caspase-1 (CASP1), an enzyme involved in cell death and inflammation, in AML cells. The researchers found that elevated CASP1 expression in AML patients is associated with shorter overall survival. They also discovered that the zymogen form of CASP1, which lacks proteolytic activity, plays a critical role in AML cells by fine-tuning inflammatory signaling pathways. The loss of this form of CASP1 exposes AML cells to vulnerabilities and may have therapeutic implications. [Extracted from the article]

A recent study conducted by the School of Pharmaceutical Education and Research in New Delhi, India, has found that oral delivery of nerolidol, a natural bioactive compound, can alleviate renal inflammation, apoptosis, and fibrosis caused by the antineoplastic drug cyclophosphamide. The study was conducted using renal cells and mice, and various markers of oxidative stress, injury, inflammation, apoptosis, and fibrosis were measured. The results showed that treatment with nerolidol significantly reduced the levels of certain markers associated with renal toxicity and reversed structural abnormalities. This study provides a potential avenue for developing an adjuvant to mitigate cyclophosphamide-induced renal toxicity in patients. [Extracted from the article]

A study conducted by researchers at Chengdu University of Traditional Chinese Medicine in Sichuan, China, has found that Tou Nong Powder (TNP), a traditional Chinese medicinal formula, may be effective in treating ulcerative colitis (UC). TNP was shown to obstruct enteric inflammation and regulate the NF-xB/NLRP3/Caspase-1/GSDMD signaling pathway, resulting in a reduction of symptoms and histopathological injury. The study suggests that TNP has potential as a therapeutic option for UC by suppressing inflammation and reducing the expression of certain cytokines. This research has been peer-reviewed and provides new insights into the treatment of UC using traditional Chinese medicine. [Extracted from the article]

A recent study conducted at the Second Affiliated Hospital explores the role of erythropoietin (EPO) in the treatment of steroid-induced avascular necrosis of the femoral head (SANFH). SANFH is characterized by osteoblast apoptosis, which leads to bone loss and impaired hip joint function. The study found that EPO can suppress osteoblast apoptosis by inhibiting the STAT1-caspase 3 signaling pathway. In both in vitro and in vivo experiments, EPO demonstrated a protective effect against SANFH. These findings suggest that EPO may be a potential treatment for SANFH. [Extracted from the article]

According to a preprint abstract, researchers have found that protein kinase C delta (PKCδ) plays a role in mediating cell death in insulin-producing islet beta-cells in type 1 diabetes. The exact mechanisms are not well understood, but the researchers used a mouse model and a small peptide inhibitor of PKCδ to investigate. They discovered that inhibiting PKCδ protected the beta-cells from cytokine-induced apoptosis, and that cytokine-activated PKCδ increased the activity of pro-apoptotic signaling in the cells. These findings may contribute to the development of new therapies to prevent or delay beta-cell death in type 1 diabetes. [Extracted from the article]

A study conducted by the Institute of Experimental Medicine explores the potential of combining nerve growth factor (NGF), cathelicidin (LL-37), and protegrin-1 (PG-1) with chemotherapy to improve the efficacy of treatment for glioblastoma (GBM), an aggressive and lethal form of brain cancer. The researchers found that NGF and the peptides demonstrated a strong cytotoxic effect on glioma cells compared to chemotherapy. Additionally, the combination of PG-1 and etoposide showed a synergistic effect on apoptosis (cell death) in the glioma cells. These findings suggest that NGF, LL-37, and PG-1 could be promising drug candidates for GBM treatment, and the combination therapy may overcome limitations of conventional protocols. [Extracted from the article]

Researchers from Xi'an Jiaotong University in Shaanxi, China, have conducted a study on the role of peroxisome proliferator-activated receptor gamma (PPAR gamma) in protecting PC12 cells against oxidative stress injury. Using a PC12 cell model with H2O2 treatment, the study investigated the expression levels of apoptosis-related genes and neuronal apoptosis after oxidative stress injury. The researchers found that pioglitazone, a PPAR gamma agonist, significantly reduced apoptosis and increased cell viability in a dose-dependent manner. This study provides insights into potential therapeutic approaches for neurodegenerative diseases. [Extracted from the article]

A study conducted at the Second Affiliated Hospital in Anhui, China, explored the protective effects of naringin (NRG) against neurotoxicity caused by 5-fluorouracil (5-FU), an antineoplastic drug. The research found that 5-FU administration led to a decrease in cerebral antioxidant enzymes and an increase in pro-inflammatory cytokines, inducible nitric oxide synthase, nuclear factor-qB, and caspase-3. However, when NRG was administered alongside 5-FU, it significantly inhibited these negative effects, suggesting that NRG may have therapeutic potential in managing 5-FU-induced neurotoxicity. The study was published in Open Chemistry and conducted by Zhou Peili and colleagues from the Department of Neurology at the Second Affiliated Hospital of Wannan Medical College. [Extracted from the article]

Keywords: Chapeco; Brazil; South America; Alkanes; Apoptosis; Apoptosis Regulatory Proteins; Aromatic Hydrocarbons; Cancer; Caspase; Caspases; Catechols; Cellular Physiology; Curcumin; Cysteine Endopeptidases; Cysteine Proteases; Diarylheptanoids; Drugs and Therapies; Effector Caspases; Enzymes and Coenzymes; Health and Medicine; Hydrocarbons; Melanoma; Oncology; Organic Chemicals; Peptide Hydrolases; Peptides EN Chapeco Brazil South America Alkanes Apoptosis Apoptosis Regulatory Proteins Aromatic Hydrocarbons Cancer Caspase Caspases Catechols Cellular Physiology Curcumin Cysteine Endopeptidases Cysteine Proteases Diarylheptanoids Drugs and Therapies Effector Caspases Enzymes and Coenzymes Health and Medicine Hydrocarbons Melanoma Oncology Organic Chemicals Peptide Hydrolases Peptides 984 984 1 11/06/23 20231110 NES 231110 2023 NOV 10 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New research on Cellular Physiology - Apoptosis is the subject of a report. Chapeco, Brazil, South America, Alkanes, Apoptosis, Apoptosis Regulatory Proteins, Aromatic Hydrocarbons, Cancer, Caspase, Caspases, Catechols, Cellular Physiology, Curcumin, Cysteine Endopeptidases, Cysteine Proteases, Diarylheptanoids, Drugs and Therapies, Effector Caspases, Enzymes and Coenzymes, Health and Medicine, Hydrocarbons, Melanoma, Oncology, Organic Chemicals, Peptide Hydrolases, Peptides. [Extracted from the article]

Keywords: Shiraz; Iran; Apoptosis Regulatory Proteins; Biotechnology; Caspase; Caspases; Cysteine Endopeptidases; Cysteine Proteases; Drugs and Therapies; Effector Caspases; Engineering; Enzymes and Coenzymes; Health and Medicine; Peptide Hydrolases; Peptides; Protein Engineering EN Shiraz Iran Apoptosis Regulatory Proteins Biotechnology Caspase Caspases Cysteine Endopeptidases Cysteine Proteases Drugs and Therapies Effector Caspases Engineering Enzymes and Coenzymes Health and Medicine Peptide Hydrolases Peptides Protein Engineering 1640 1640 1 10/30/23 20231103 NES 231103 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on Engineering - Protein Engineering have been published. Shiraz, Iran, Apoptosis Regulatory Proteins, Biotechnology, Caspase, Caspases, Cysteine Endopeptidases, Drugs and Therapies, Effector Caspases, Engineering, Enzymes and Coenzymes, Health and Medicine, Peptide Hydrolases, Peptides, Protein Engineering, Cysteine Proteases. [Extracted from the article]

Keywords: Zhejiang; People's Republic of China; Asia; AMP-Activated Protein Kinases; Apoptosis Regulatory Proteins; Caspase; Caspases; Cysteine Endopeptidases; Cysteine Proteases; Digestive System Diseases and Conditions; Effector Caspases; Enzymes and Coenzymes; Fatty Liver; Fatty Liver Disease; Health and Medicine; Intracellular Signaling Peptides and Proteins; Kinase; Liver Diseases and Conditions; Non-Alcoholic Fatty Liver Disease; Peptide Hydrolases; Peptides; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein-Serine-Threonine Kinases EN Zhejiang People's Republic of China Asia AMP-Activated Protein Kinases Apoptosis Regulatory Proteins Caspase Caspases Cysteine Endopeptidases Cysteine Proteases Digestive System Diseases and Conditions Effector Caspases Enzymes and Coenzymes Fatty Liver Fatty Liver Disease Health and Medicine Intracellular Signaling Peptides and Proteins Kinase Liver Diseases and Conditions Non-Alcoholic Fatty Liver Disease Peptide Hydrolases Peptides Phosphotransferases Phosphotransferases (Alcohol Group Acceptor) Protein Kinases Protein-Serine-Threonine Kinases 996 996 1 10/30/23 20231103 NES 231103 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Liver Diseases and Conditions - Non-Alcoholic Fatty Liver Disease. Zhejiang, People's Republic of China, Asia, AMP-Activated Protein Kinases, Apoptosis Regulatory Proteins, Caspase, Caspases, Cysteine Endopeptidases, Cysteine Proteases, Digestive System Diseases and Conditions, Effector Caspases, Enzymes and Coenzymes, Fatty Liver Disease, Health and Medicine, Intracellular Signaling Peptides and Proteins, Kinase, Liver Diseases and Conditions, Non-Alcoholic Fatty Liver Disease, Peptide Hydrolases, Peptides, Phosphotransferases, Phosphotransferases (Alcohol Group Acceptor), Protein Kinases, Protein-Serine-Threonine Kinases, Fatty Liver. [Extracted from the article]

Keywords for this news article include: Zagazig University, Zagazig, Egypt, Africa, Antineoplastics, Oncology, Peroxidases, Liver Cancer, Oxidoreductases, Aminotransferase, Cisplatin Therapy, Effector Caspases, Chlorine Compounds, Cysteine Proteases, Initiator Caspases, Nitrogen Compounds, Peptide Hydrolases, Platinum Compounds, Drugs and Therapies, Health and Medicine, Enzymes and Coenzymes. Aminotransferase, Antineoplastics, Apoptosis Regulatory Proteins, Cancer, Caspase, Caspases, Cisplatin Therapy, Chlorine Compounds, Cysteine Endopeptidases, Cysteine Proteases, Drugs and Therapies, Effector Caspases, Enzymes and Coenzymes, Health and Medicine, Initiator Caspases, Intercellular Signaling Peptides and Proteins, Intracellular Signaling Peptides and Proteins, Liver Cancer, Nitrogen Compounds, Oncology, Oxidoreductases, Peptide Hydrolases, Peptides, Peroxidases, Transforming Growth Factors, Platinum Compounds. [Extracted from the article]

Keywords: Amino Acids; Cysteine; Cysteine Proteases; Enzymes and Coenzymes; Neutral Amino Acids; Peptide Hydrolases; Protease; Sulfhydryl Compounds; Sulfur Amino Acids EN Amino Acids Cysteine Cysteine Proteases Enzymes and Coenzymes Neutral Amino Acids Peptide Hydrolases Protease Sulfhydryl Compounds Sulfur Amino Acids 1855 1855 1 10/16/23 20231020 NES 231020 2023 OCT 20 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on amino acids have been published. LC-MS/MS analyzed the protein sequence of purified protease and the data suggested that the enzyme might be related to the cysteine protease. [Extracted from the article]

Keywords: Apoptosis Regulatory Proteins; Biomedicine; Blood Cells; Bone Marrow Cells; Cardiology; Caspase; Caspases; Cell Research; Cysteine Endopeptidases; Cysteine Proteases; Cytokines; Drugs and Therapies; Enzymes and Coenzymes; Health and Medicine; Heart Transplants; Hemic and Immune Systems; Immunology; Initiator Caspases; Intercellular Signaling Peptides and Proteins; Interferons; Intracellular Signaling Peptides and Proteins; Monocytes; Mononuclear Leukocytes; Mononuclear Phagocyte System; Myeloid Cells; Organ Transplants; Peptide Hydrolases; Peptides; Phagocytes; Surgery; Transplant Medicine; Transplantation EN Apoptosis Regulatory Proteins Biomedicine Blood Cells Bone Marrow Cells Cardiology Caspase Caspases Cell Research Cysteine Endopeptidases Cysteine Proteases Cytokines Drugs and Therapies Enzymes and Coenzymes Health and Medicine Heart Transplants Hemic and Immune Systems Immunology Initiator Caspases Intercellular Signaling Peptides and Proteins Interferons Intracellular Signaling Peptides and Proteins Monocytes Mononuclear Leukocytes Mononuclear Phagocyte System Myeloid Cells Organ Transplants Peptide Hydrolases Peptides Phagocytes Surgery Transplant Medicine Transplantation 469 469 1 09/25/23 20230929 NES 230929 2023 SEP 25 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on heart transplants have been published. Our news editors obtained a quote from the research from Southern Medical University: "At 3 days post-transplant, eGFP-positive cells infiltrating the grafts were sorted and subjected to single-cell RNA-seq analysis. [Extracted from the article]

Keywords: Apoptosis; Apoptosis Regulatory Proteins; Cancer; Caspase; Caspases; Cell Proliferation; Cellular Physiology; Cysteine Endopeptidases; Cysteine Proteases; Enzymes and Coenzymes; Genetics; Health and Medicine; Initiator Caspases; Intracellular Signaling Peptides and Proteins; Lung Cancer; Lung Diseases and Conditions; Lung Neoplasms; Non-Small Cell Lung Cancer; Oncology; Peptide Hydrolases; Peptides; Protein Expression; Proteomics EN Apoptosis Apoptosis Regulatory Proteins Cancer Caspase Caspases Cell Proliferation Cellular Physiology Cysteine Endopeptidases Cysteine Proteases Enzymes and Coenzymes Genetics Health and Medicine Initiator Caspases Intracellular Signaling Peptides and Proteins Lung Cancer Lung Diseases and Conditions Lung Neoplasms Non-Small Cell Lung Cancer Oncology Peptide Hydrolases Peptides Protein Expression Proteomics 1022 1022 1 09/19/23 20230922 NES 230922 2023 SEP 19 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Data detailed on non-small cell lung cancer have been presented. According to the news editors, the research concluded: "Down-regulating NORAD expression can enhance miR-199a-3p expression and inhibit ZNF217 expression, thereby inhibiting H460/DDP cell proliferation, promoting apoptosis and enhancing its DDP chemotherapy sensitivity." Compared with the control group and si-NC group, the proliferation rate, NORAD and ZNF217 mRNA expression, Ki-67 and ZNF217 protein expression of H460/DDP cells in the si-NORAD group were significantly reduced (P<0.05), but the apoptosis rate, miR-199a-3p expression and caspase-9 expression were significantly increased (P<0.05). [Extracted from the article]

Keywords: Sichuan; People's Republic of China; Asia; 4-Aminobenzoic Acid; Anesthetics; Apoptosis Regulatory Proteins; Carboxylic Acids; Caspase; Caspases; Central Nervous System Agents; Central Nervous System Depressants; Connective Tissue Cells; Cysteine Endopeptidases; Cysteine Proteases; Drugs and Therapies; Enzymes and Coenzymes; Health and Medicine; Immunology; Initiator Caspases; Intracellular Signaling Peptides and Proteins; Local Anesthetic Therapy; Local Anesthetics Therapy; Macrophages; Mononuclear Phagocyte System; Myeloid Cells; Ophthalmic Anesthetics; Ophthalmic Preparations; Peptide Hydrolases; Peptides; Phagocytes; Pharmaceuticals; Pyroptosis; Tetracaine; Tetracaine Therapy EN Sichuan People's Republic of China Asia 4-Aminobenzoic Acid Anesthetics Apoptosis Regulatory Proteins Carboxylic Acids Caspase Caspases Central Nervous System Agents Central Nervous System Depressants Connective Tissue Cells Cysteine Endopeptidases Cysteine Proteases Drugs and Therapies Enzymes and Coenzymes Health and Medicine Immunology Initiator Caspases Intracellular Signaling Peptides and Proteins Local Anesthetic Therapy Local Anesthetics Therapy Macrophages Mononuclear Phagocyte System Myeloid Cells Ophthalmic Anesthetics Ophthalmic Preparations Peptide Hydrolases Peptides Phagocytes Pharmaceuticals Pyroptosis Tetracaine Tetracaine Therapy 1589 1589 1 09/19/23 20230922 NES 230922 2023 SEP 22 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on Pyroptosis have been published. According to the news reporters, the research concluded: "Therapies targeting pyroptosis may potentially provide a promising future strategy for the prevention and treatment of local anesthetic toxicity induced by TTC.". [Extracted from the article]

Keywords for this news article include: Istanbul, Turkey, Eurasia, Antineoplastics, Apoptosis, Apoptosis Regulatory Proteins, Bortezomib Therapy, Caspase, Caspases, Cell Proliferation, Cellular Physiology, Cysteine Endopeptidases, Cysteine Proteases, Drugs and Therapies, Effector Caspases, Enzymes and Coenzymes, Gliomas, Health and Medicine, Oncology, Peptide Hydrolases, Peptides, Pharmaceuticals, Medipol University. Istanbul, Turkey, Eurasia, Antineoplastics, Apoptosis, Apoptosis Regulatory Proteins, Bortezomib Therapy, Caspase, Caspases, Cell Proliferation, Cellular Physiology, Cysteine Endopeptidases, Cysteine Proteases, Drugs and Therapies, Effector Caspases, Enzymes and Coenzymes, Gliomas, Health and Medicine, Oncology, Peptide Hydrolases, Peptides, Pharmaceuticals Keywords: Istanbul; Turkey; Eurasia; Antineoplastics; Apoptosis; Apoptosis Regulatory Proteins; Bortezomib Therapy; Caspase; Caspases; Cell Proliferation; Cellular Physiology; Cysteine Endopeptidases; Cysteine Proteases; Drugs and Therapies; Effector Caspases; Enzymes and Coenzymes; Gliomas; Health and Medicine; Oncology; Peptide Hydrolases; Peptides; Pharmaceuticals EN Istanbul Turkey Eurasia Antineoplastics Apoptosis Apoptosis Regulatory Proteins Bortezomib Therapy Caspase Caspases Cell Proliferation Cellular Physiology Cysteine Endopeptidases Cysteine Proteases Drugs and Therapies Effector Caspases Enzymes and Coenzymes Gliomas Health and Medicine Oncology Peptide Hydrolases Peptides Pharmaceuticals 389 389 1 09/19/23 20230922 NES 230922 2023 SEP 19 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Data detailed on Oncology - Gliomas have been presented. [Extracted from the article]

New Delhi, India, Asia, Amino Acids, Cysteine, Cysteine Proteases, Enzymes and Coenzymes, Health and Medicine, Human Parasites, Leishmaniasis, Neutral Amino Acids, Parasitic Diseases and Conditions, Peptide Hydrolases, Protease, Protozoan Parasites, Sulfhydryl Compounds, Sulfur Amino Acids, Sulfur Compounds, Thiazoles, Thiazolidinediones, Thiazolidines Keywords: New Delhi; India; Asia; Amino Acids; Cysteine; Cysteine Proteases; Enzymes and Coenzymes; Health and Medicine; Human Parasites; Leishmaniasis; Neutral Amino Acids; Parasitic Diseases and Conditions; Peptide Hydrolases; Protease; Protozoan Parasites; Sulfhydryl Compounds; Sulfur Amino Acids; Sulfur Compounds; Thiazoles; Thiazolidinediones; Thiazolidines EN New Delhi India Asia Amino Acids Cysteine Cysteine Proteases Enzymes and Coenzymes Health and Medicine Human Parasites Leishmaniasis Neutral Amino Acids Parasitic Diseases and Conditions Peptide Hydrolases Protease Protozoan Parasites Sulfhydryl Compounds Sulfur Amino Acids Sulfur Compounds Thiazoles Thiazolidinediones Thiazolidines 2327 2327 1 09/04/23 20230908 NES 230908 2023 SEP 8 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Parasitic Diseases and Conditions - Leishmaniasis. [Extracted from the article]

Keywords for this news article include: Kerman, Iran, Apoptosis, Apoptosis Regulatory Proteins, Caspase, Caspases, Cellular Physiology, Cysteine Endopeptidases, Cysteine Proteases, Drugs and Therapies, Effector Caspases, Enzymes and Coenzymes, Health and Medicine, Inflammation, Peptide Hydrolases, Peptides, Pharmaceuticals, Risk and Prevention, Kerman University of Medical Sciences. Keywords: Kerman; Iran; Apoptosis; Apoptosis Regulatory Proteins; Caspase; Caspases; Cellular Physiology; Cysteine Endopeptidases; Cysteine Proteases; Drugs and Therapies; Effector Caspases; Enzymes and Coenzymes; Health and Medicine; Inflammation; Peptide Hydrolases; Peptides; Pharmaceuticals; Risk and Prevention EN Kerman Iran Apoptosis Apoptosis Regulatory Proteins Caspase Caspases Cellular Physiology Cysteine Endopeptidases Cysteine Proteases Drugs and Therapies Effector Caspases Enzymes and Coenzymes Health and Medicine Inflammation Peptide Hydrolases Peptides Pharmaceuticals Risk and Prevention 801 801 1 08/28/23 20230901 NES 230901 2023 SEP 1 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Research findings on Cellular Physiology - Apoptosis are discussed in a new report. [Extracted from the article]

Keywords: Alkylating Agents; Antineoplastics; Antiplatelet Agents; Apoptosis Regulatory Proteins; Cardiovascular Agents; Caspase; Caspases; Chlorine Compounds; Cilostazol Therapy; Cisplatin Therapy; Coagulation Modifiers; Cysteine Endopeptidases; Cysteine Proteases; Drugs and Therapies; Effector Caspases; Enzymes and Coenzymes; Health and Medicine; Inflammation; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Nitrogen Compounds; Peptide Hydrolases; Peptides; Pharmaceuticals; Phosphodiesterases; Platelet Aggregation Inhibitors; Platinum Compounds; Tumor Necrosis Factors EN Alkylating Agents Antineoplastics Antiplatelet Agents Apoptosis Regulatory Proteins Cardiovascular Agents Caspase Caspases Chlorine Compounds Cilostazol Therapy Cisplatin Therapy Coagulation Modifiers Cysteine Endopeptidases Cysteine Proteases Drugs and Therapies Effector Caspases Enzymes and Coenzymes Health and Medicine Inflammation Intercellular Signaling Peptides and Proteins Membrane Proteins Nitrogen Compounds Peptide Hydrolases Peptides Pharmaceuticals Phosphodiesterases Platelet Aggregation Inhibitors Platinum Compounds Tumor Necrosis Factors 811 811 1 08/28/23 20230901 NES 230901 2023 SEP 1 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New research on platelet aggregation inhibitors is the subject of a new report. Alkylating Agents, Antineoplastics, Antiplatelet Agents, Apoptosis Regulatory Proteins, Cardiovascular Agents, Caspase, Caspases, Chlorine Compounds, Cilostazol Therapy, Cisplatin Therapy, Coagulation Modifiers, Cysteine Endopeptidases, Cysteine Proteases, Drugs and Therapies, Effector Caspases, Enzymes and Coenzymes, Health and Medicine, Inflammation, Intercellular Signaling Peptides and Proteins, Membrane Proteins, Nitrogen Compounds, Peptide Hydrolases, Peptides, Pharmaceuticals, Phosphodiesterases, Platelet Aggregation Inhibitors, Platinum Compounds, Tumor Necrosis Factors. [Extracted from the article]

Keywords for this news article include: Bethesda, Maryland, United States, North and Central America, Antiparasitics, Apoptosis, Apoptosis Regulatory Proteins, Caspase, Caspases, Cellular Physiology, Cysteine Endopeptidases, Cysteine Proteases, Cytoplasmic Structures, Cytoplasmic Vesicles, Enzymes and Coenzymes, Galectin 3, Galectins, Health and Medicine, Initiator Caspases, Intracellular Signaling Peptides and Proteins, Intracellular Space, Lectins, Lysosomes, Membrane Proteins, Peptide Hydrolases, Peptides, Proteins, National Institutes of Health (NIH). Keywords: Bethesda; State:Maryland; United States; North and Central America; Antiparasitics; Apoptosis; Apoptosis Regulatory Proteins; Caspase; Caspases; Cellular Physiology; Cysteine Endopeptidases; Cysteine Proteases; Cytoplasmic Structures; Cytoplasmic Vesicles; Enzymes and Coenzymes; Galectin 3; Galectins; Health and Medicine; Initiator Caspases; Intracellular Signaling Peptides and Proteins; Intracellular Space; Lectins; Lysosomes; Membrane Proteins; Peptide Hydrolases; Peptides; Proteins EN Bethesda State:Maryland United States North and Central America Antiparasitics Apoptosis Apoptosis Regulatory Proteins Caspase Caspases Cellular Physiology Cysteine Endopeptidases Cysteine Proteases Cytoplasmic Structures Cytoplasmic Vesicles Enzymes and Coenzymes Galectin 3 Galectins Health and Medicine Initiator Caspases Intracellular Signaling Peptides and Proteins Intracellular Space Lectins Lysosomes Membrane Proteins Peptide Hydrolases Peptides Proteins 1745 1745 1 08/28/23 20230901 NES 230901 2023 SEP 1 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Cellular Physiology - Apoptosis. [Extracted from the article]

Keywords: Beijing; People's Republic of China; Asia; Apoptosis Regulatory Proteins; Caspase; Caspases; Cysteine Endopeptidases; Cysteine Proteases; Drugs and Therapies; Effector Caspases; Enzymes and Coenzymes; Epithelial Cells; Health and Medicine; Influenza; Peptide Hydrolases; Peptides; Pyroptosis EN Beijing People's Republic of China Asia Apoptosis Regulatory Proteins Caspase Caspases Cysteine Endopeptidases Cysteine Proteases Drugs and Therapies Effector Caspases Enzymes and Coenzymes Epithelial Cells Health and Medicine Influenza Peptide Hydrolases Peptides Pyroptosis 878 878 1 07/24/23 20230725 NES 230725 2023 JUL 28 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on Pyroptosis have been published. Beijing, People's Republic of China, Asia, Apoptosis Regulatory Proteins, Caspase, Caspases, Cysteine Endopeptidases, Cysteine Proteases, Drugs and Therapies, Effector Caspases, Enzymes and Coenzymes, Epithelial Cells, Health and Medicine, Influenza, Peptide Hydrolases, Peptides, Pyroptosis. [Extracted from the article]

Keywords: Apoptosis Regulatory Proteins; Cancer; Carcinomas; Caspase; Caspases; Chalcogens; Colon Cancer; Colorectal Research; Cysteine Endopeptidases; Cysteine Proteases; Drugs and Therapies; Effector Caspases; Enzymes and Coenzymes; Gastroenterology; Health and Medicine; Oncology; Oxygen Compounds; Peptide Hydrolases; Peptides; Reactive Oxygen Species EN Apoptosis Regulatory Proteins Cancer Carcinomas Caspase Caspases Chalcogens Colon Cancer Colorectal Research Cysteine Endopeptidases Cysteine Proteases Drugs and Therapies Effector Caspases Enzymes and Coenzymes Gastroenterology Health and Medicine Oncology Oxygen Compounds Peptide Hydrolases Peptides Reactive Oxygen Species 1362 1362 1 07/17/23 20230721 NES 230721 2023 JUL 18 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New study results on colon cancer have been published. Apoptosis Regulatory Proteins, Cancer, Carcinomas, Caspase, Caspases, Chalcogens, Colon Cancer, Colorectal Research, Cysteine Endopeptidases, Cysteine Proteases, Drugs and Therapies, Effector Caspases, Enzymes and Coenzymes, Gastroenterology, Health and Medicine, Oncology, Oxygen Compounds, Peptide Hydrolases, Peptides, Reactive Oxygen Species. [Extracted from the article]

Keywords for this news article include: Iowa City, Iowa, United States, North and Central America, Apoptosis Regulatory Proteins, Caspase, Caspases, Cysteine Endopeptidases, Cysteine Proteases, Effector Caspases, Enzymes and Coenzymes, Peptide Hydrolases, Peptides, University of Iowa. Iowa City, State:Iowa, United States, North and Central America, Apoptosis Regulatory Proteins, Caspase, Caspases, Cysteine Endopeptidases, Cysteine Proteases, Effector Caspases, Enzymes and Coenzymes, Peptide Hydrolases, Peptides Keywords: Iowa City; State:Iowa; United States; North and Central America; Apoptosis Regulatory Proteins; Caspase; Caspases; Cysteine Endopeptidases; Cysteine Proteases; Effector Caspases; Enzymes and Coenzymes; Peptide Hydrolases; Peptides EN Iowa City State:Iowa United States North and Central America Apoptosis Regulatory Proteins Caspase Caspases Cysteine Endopeptidases Cysteine Proteases Effector Caspases Enzymes and Coenzymes Peptide Hydrolases Peptides 1828 1828 1 06/19/23 20230623 NES 230623 2023 JUN 23 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Fresh data on Enzymes and Coenzymes - Effector Caspases are presented in a new report. [Extracted from the article]

Keywords for this news article include: Liaoning, People's Republic of China, Asia, Apoptosis Regulatory Proteins, Blood Brain Barrier, Blood Diseases and Conditions, Blood-Brain Barrier, Bloodstream Infection, Brain Research, Caspase, Caspases, Central Nervous System, Cysteine Endopeptidases, Cysteine Proteases, Drugs and Therapies, Enzymes and Coenzymes, Health and Medicine, Initiator Caspases, Intracellular Signaling Peptides and Proteins, Peptide Hydrolases, Peptides, Pharmaceuticals, Pyroptosis, Risk and Prevention, Sepsis, Septicemia, China Medical University. Keywords: Liaoning; People's Republic of China; Asia; Apoptosis Regulatory Proteins; Blood Brain Barrier; Blood Diseases and Conditions; Blood-Brain Barrier; Bloodstream Infection; Brain Research; Caspase; Caspases; Central Nervous System; Cysteine Endopeptidases; Cysteine Proteases; Drugs and Therapies; Enzymes and Coenzymes; Health and Medicine; Initiator Caspases; Intracellular Signaling Peptides and Proteins; Peptide Hydrolases; Peptides; Pharmaceuticals; Pyroptosis; Risk and Prevention; Sepsis; Septicemia EN Liaoning People's Republic of China Asia Apoptosis Regulatory Proteins Blood Brain Barrier Blood Diseases and Conditions Blood-Brain Barrier Bloodstream Infection Brain Research Caspase Caspases Central Nervous System Cysteine Endopeptidases Cysteine Proteases Drugs and Therapies Enzymes and Coenzymes Health and Medicine Initiator Caspases Intracellular Signaling Peptides and Proteins Peptide Hydrolases Peptides Pharmaceuticals Pyroptosis Risk and Prevention Sepsis Septicemia 381 381 1 06/19/23 20230623 NES 230623 2023 JUN 22 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New research on Blood Diseases and Conditions - Sepsis is the subject of a report. [Extracted from the article]

Kidney injury that occurs with sorafenib chemotherapeutic treatment is a major clinical challenge that lacks a drug to revert or reduce this kidney glomerular cell damage." Keywords: Antineoplastics; Apoptosis Regulatory Proteins; Caspase; Caspases; Connective Tissue Cells; Cysteine Endopeptidases; Cysteine Proteases; Drugs and Therapies; Effector Caspases; Enzymes and Coenzymes; Epoxide Hydrolases; Fibroblasts; Health and Medicine; Kidney Glomerulus; Mesangial Cells; Multikinase Inhibitors; Peptide Hydrolases; Peptides; Pharmaceuticals; Sorafenib Therapy; Tyrosine Kinase Inhibitors; Urinary Tract; Urogenital System; VEGF - VEGFR Inhibitors; VEGFR Inhibitors EN Antineoplastics Apoptosis Regulatory Proteins Caspase Caspases Connective Tissue Cells Cysteine Endopeptidases Cysteine Proteases Drugs and Therapies Effector Caspases Enzymes and Coenzymes Epoxide Hydrolases Fibroblasts Health and Medicine Kidney Glomerulus Mesangial Cells Multikinase Inhibitors Peptide Hydrolases Peptides Pharmaceuticals Sorafenib Therapy Tyrosine Kinase Inhibitors Urinary Tract Urogenital System VEGF - VEGFR Inhibitors VEGFR Inhibitors 2192 2192 1 06/12/23 20230616 NES 230616 2023 JUN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Fresh data on tyrosine kinase inhibitors are presented in a new report. [Extracted from the article]

We have demonstrated that PASMCs from a well-established rat model of disease have increased expression of the membrane protein aquaporin 1 (AQP1) which is associated with increased cell migration, proliferation, and resistance to apoptosis. Keywords: Apoptosis Regulatory Proteins; Aquaporin 1; Aquaporins; Biotin; Carrier Proteins; Caspase; Caspases; Chemicals; Coenzymes; Cysteine Endopeptidases; Cysteine Proteases; Diet and Nutrition; Drugs and Therapies; Effector Caspases; Enzymes and Coenzymes; Health and Medicine; Hydrogen Peroxide; Ion Channels; Ligases; Membrane Glycoproteins; Membrane Proteins; Membrane Transport Proteins; Micronutrient; Muscle Cells; Peptide Hydrolases; Peptides; Pharmaceuticals; Porins EN Apoptosis Regulatory Proteins Aquaporin 1 Aquaporins Biotin Carrier Proteins Caspase Caspases Chemicals Coenzymes Cysteine Endopeptidases Cysteine Proteases Diet and Nutrition Drugs and Therapies Effector Caspases Enzymes and Coenzymes Health and Medicine Hydrogen Peroxide Ion Channels Ligases Membrane Glycoproteins Membrane Proteins Membrane Transport Proteins Micronutrient Muscle Cells Peptide Hydrolases Peptides Pharmaceuticals Porins 970 970 1 06/12/23 20230616 NES 230616 2023 JUN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on effector caspases. [Extracted from the article]