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Researchers from the University of Bari 'Aldo Moro' in Italy have conducted a study on the manufacturing and characterization of nanoparticles (NPs) using a microfluidic method. The study aimed to control the physicochemical properties of the NPs and reduce batch-to-batch variability. The researchers optimized the formulation of NPs loaded with the drug pentamidine using the microfluidic technique, and in vitro studies showed potential antitumor activity. This research was supported by the Ministry of Education, Universities and Research (MIUR) and has been peer-reviewed. [Extracted from the article]

Researchers from the University of Bari 'Aldo Moro' in Italy have developed a self-powered wearable biosensor that can detect alcohol abuse through sweat analysis. The biosensor uses a water-based graphite ink modified with multiwalled carbon nanotubes and is printed onto a flexible substrate. The biosensor demonstrated a linear detection range from 0.01 to 0.3 mM of ethanol, with a detection limit of 3 +/- 1 mu M and a sensitivity of 64 +/- 2 mu W mM-1. The biosensor also showed excellent operational and storage stability and was successfully integrated into a wristband for continuous alcohol abuse monitoring. This research offers potential applications in forensic contexts. [Extracted from the article]

Researchers from the University of Bari 'Aldo Moro' in Italy have conducted a review exploring the impact of flavin homeostasis on cancer cell metabolism. Flavins, including flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), are coenzymes involved in various cellular processes. The review highlights the extended role of flavins in cancer, including their influence on cancer cell energetics, their potential as diagnostic markers and therapeutic targets, and their implications in drug resistance and apoptosis. The researchers suggest that targeting flavins and related processes could offer new strategies for diagnosing and treating cancer. [Extracted from the article]

A new report discusses research conducted at the University of Bari 'Aldo Moro' in Italy on the treatment of oral ulcers in Behçet's disease (BD). The study compared the effectiveness and safety of TNF inhibitors (TNFis) and apremilast in controlling oral ulcers in BD patients. The study found that both treatments significantly reduced oral ulcers, with apremilast having a notable effect in reducing the use of corticosteroids. TNFis were more effective in addressing articular involvement, while apremilast had a higher discontinuation rate due to gastrointestinal side effects. The research suggests that treatment selection should consider individual disease severity and clinical features for personalized management strategies. [Extracted from the article]

Researchers at the University of Bari 'Aldo Moro' in Italy have developed a new method for delivering brain-derived neurotrophic factor (BDNF) to the brain using microfluidic-based nanoscale drug delivery systems. BDNF is important for healing brain injuries, and this new formulation of BDNF-loaded solid lipid nanoparticles (BDNF-SLNs) showed promising results in terms of size, stability, and permeability. The researchers found that BDNF-SLNs were more effective in reducing neuroinflammation compared to plain BDNF. This study highlights the potential of microfluidic-based drug delivery systems for the treatment of brain injuries. [Extracted from the article]

Researchers at the University of Bari 'Aldo Moro' in Italy have conducted a study on the use of polydopamine (PDA) coating as an alternative to PEGylation for stabilizing liposomes, which are nanocarriers used in biomedical applications. PEGylation is currently the most common method for stabilization, but it can have side effects. The researchers found that PDA-coated liposomes exhibited similar behavior to PEG-coated liposomes in biological fluids, suggesting that PDA coating could be a viable alternative. The study was supported by financial grants from the European Union and the Italian government. [Extracted from the article]

A recent study conducted at the University of Bari in Italy explores the potential health benefits of cynara scolymus, a type of artichoke. The study suggests that cynara scolymus, which is rich in bioactive compounds, may have various health-promoting properties. These include anti-inflammatory, antioxidant, liver-protective, bile-expelling, antimicrobial, and lipid-lowering effects. The high concentration of polyphenols in cynara scolymus gives it antioxidant activity, which can help neutralize free radicals and reduce the risk of developing conditions such as cancer, diabetes, and cardiovascular diseases. The study concludes by discussing the nutritional profiles and potential therapeutic effects of cynara scolymus. [Extracted from the article]

A study conducted at the University of Bari in Italy has found that high concentrations of urinary calcium can counteract the action of vasopressin, a hormone involved in water regulation in the body. This counteraction occurs through the activation of the Calcium-Sensing Receptor (CaSR) in the collecting duct cells of the kidney, which impairs the trafficking of aquaporin-2 (AQP2), a protein involved in water reabsorption. The study also found that mice with a genetic mutation mimicking a condition called autosomal dominant hypocalcaemia displayed decreased levels of AQP2 and increased levels of AQP2 phosphorylation, which leads to its degradation. Treatment with a CaSR antagonist was able to reverse these effects. These findings provide evidence for the role of CaSR in impairing the response to vasopressin and reducing AQP2 abundance. [Extracted from the article]

A study conducted at the University of Bari 'Aldo Moro' in Italy investigated the effects of two different anti-VEGF drugs on choroidal morphology in patients with exudative age-related macular degeneration (AMD). The study included 73 treatment-naive eyes and compared the effects of intravitreal aflibercept and brolucizumab. The results showed that both drugs led to a reduction in sub-foveal choroidal thickness, but only brolucizumab had a significant impact on choroidal remodeling. The study suggests that brolucizumab may be more effective in modifying choroidal morphology in patients with type 1 neovascular AMD compared to aflibercept. [Extracted from the article]

Keywords for this news article include: Bari, Italy, Europe, Cell Research, Drug Candidates, Drug Development, Drugs and Therapies, Health and Medicine, Tumor Cell Line, University of Bari "Aldo Moro". Keywords: Bari; Italy; Europe; Cell Research; Drug Candidates; Drug Development; Drugs and Therapies; Health and Medicine; Tumor Cell Line EN Bari Italy Europe Cell Research Drug Candidates Drug Development Drugs and Therapies Health and Medicine Tumor Cell Line 1053 1053 1 10/30/23 20231103 NES 231103 2023 OCT 31 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on Drugs and Therapies - Drug Candidates have been published. Reports from University of Bari "Aldo Moro" Provide New Insights into Drug Candidates [Pt(ii) and Pt(iv) Complexes With a Major Component of Royal Jelly As Innovative Antitumor Drug Candidates]. [Extracted from the article]

New Antineoplastics Study Findings Recently Were Reported by Researchers at University of Bari "Aldo Moro" (Thermoresponsive Mucoadhesive Hydrogel Based On Pluronic F127/ Thiolated Glycol Chitosan for Intravesical Administration of Celecoxib/...) Keywords: Bari; Italy; Europe; Analgesics; Antimetabolites; Antineoplastics; Antivirals; COX-2 Inhibitors; Celecoxib Therapy; Central Nervous System Agents; Drugs and Therapies; Gemcitabine Therapy; Health and Medicine; Immunosuppressive Agents; Intravesical Administration; Pharmaceuticals; Radiation-Sensitizing Agents; Topical Administration EN Bari Italy Europe Analgesics Antimetabolites Antineoplastics Antivirals COX-2 Inhibitors Celecoxib Therapy Central Nervous System Agents Drugs and Therapies Gemcitabine Therapy Health and Medicine Immunosuppressive Agents Intravesical Administration Pharmaceuticals Radiation-Sensitizing Agents Topical Administration 1334 1334 1 09/04/23 20230908 NES 230908 2023 SEP 8 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Research findings on Drugs and Therapies - Antineoplastics are discussed in a new report. Bari, Italy, Europe, Analgesics, Antimetabolites, Antineoplastics, Antivirals, COX-2 Inhibitors, Celecoxib Therapy, Central Nervous System Agents, Drugs and Therapies, Gemcitabine Therapy, Health and Medicine, Immunosuppressive Agents, Pharmaceuticals, Radiation-Sensitizing Agents, Topical Administration, Intravesical Administration. [Extracted from the article]

For more information on this research see: Gene Expression Comparison Between Alcohol-exposed Versus Not Exposed Pancreatic Ductal Adenocarcinoma Patients Reveals a Peculiar Tgf Beta-related Phenotype: an Exploratory Analysis. Keywords: Bari; Italy; Europe; Adenocarcinoma; Cancer; Drugs and Therapies; Gastroenterology; Genetics; Health and Medicine; Oncology; Pancreas; Pharmaceuticals EN Bari Italy Europe Adenocarcinoma Cancer Drugs and Therapies Gastroenterology Genetics Health and Medicine Oncology Pancreas Pharmaceuticals 1500 1500 1 07/17/23 20230721 NES 230721 2023 JUL 17 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- A new study on Oncology - Adenocarcinoma is now available. [Extracted from the article]