1. Potential pharmacodynamic drug-drug interaction between concomitantly administered lisinopril and diclofenac sodium: a call for appropriate management in hypertensive osteoarthritic patients
- Author
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Sunita Jain, Hiren Chudasama, D. D. Santani, and Sailendra Goswami
- Subjects
Adult ,Male ,Diclofenac ,Platelet Aggregation ,Renal function ,Angiotensin-Converting Enzyme Inhibitors ,Blood Pressure ,Pharmacology ,Kidney ,chemistry.chemical_compound ,Lisinopril ,Osteoarthritis ,medicine ,Humans ,Drug Interactions ,Pharmacology (medical) ,Blood urea nitrogen ,Aged ,Creatinine ,medicine.diagnostic_test ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Sodium ,Diclofenac Sodium ,Middle Aged ,Blood pressure ,chemistry ,Pharmacodynamics ,Hypertension ,Potassium ,Female ,Lipid profile ,business ,circulatory and respiratory physiology ,medicine.drug - Abstract
BACKGROUND The present study was designed as an open label, multiple-dose, randomized, parallel trial to evaluate the pharmacodynamic drug-drug interaction of lisinopril and concomitantly administered diclofenac sodium in non-diabetic and diabetic, mild to moderate hypertensive, osteoarthritic patients. METHODS Post-screening and on inclusion, patients were put on a 2-week washout period and then randomly assigned to either only lisinopril 10 mg or combination of lisinopril 10 mg and diclofenac sodium 100 mg treatments for 8-12 weeks in diseased states of hypertension and osteoarthritis with or without type 2 diabetes mellitus. RESULTS The blood pressure (BP) control with lisinopril was reduced by concomitantly administered diclofenac sodium in non-diabetic (SBP: p=0.00002; DBP: p=0.000008) and diabetic (SBP: p=0.002; DBP: p=0.001) patients when compared with the patients receiving lisinopril alone. Insulin sensitivity was improved (p=0.00002) and urinary albumin excretion rate was better controlled (p=0.0096) in lisinopril-treated patients when compared with the combination treatment in diabetic pool. Serum creatinine levels increased significantly in non-diabetic patients (p=0.00004) receiving combination treatment. In addition, creatinine clearance (CLCR) and blood urea nitrogen (BUN) were significantly higher in diabetic (CLCR: p
- Published
- 2011