1. P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
- Author
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Karl-Dimiter Bissig, Francis P. Pankowicz, Liang Ding, Xinxin Ding, Nataliia Kovalchuk, Qing Yu Zhang, Mercedes Barzi, Weiguo Han, and Xiaoyu Fan
- Subjects
0301 basic medicine ,Pharmaceutical Science ,Computational biology ,Biology ,030226 pharmacology & pharmacy ,Xenobiotics ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Cytochrome P-450 Enzyme System ,Animals ,Humans ,Pharmacology ,Human liver ,Special Section – New Models in Drug Metabolism and Transport ,Chimera ,Experimental Animal Models ,Key features ,Disease Models, Animal ,030104 developmental biology ,Liver metabolism ,Drug development ,Liver ,Toxicity ,Humanized mouse ,Inactivation, Metabolic ,Models, Animal ,Drug metabolism - Abstract
Preclinical evaluation of drug candidates in experimental animal models is an essential step in drug development. Humanized mouse models have emerged as a promising alternative to traditional animal models. The purpose of this mini-review is to provide a brief survey of currently available mouse models for studying human xenobiotic metabolism. Here, we describe both genetic humanization and human liver chimeric mouse models, focusing on the advantages and limitations while outlining their key features and applications. Although this field of biomedical science is relatively young, these humanized mouse models have the potential to transform preclinical drug testing and eventually lead to a more cost-effective and rapid development of new therapies.
- Published
- 2018