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Aim: The aim of this study is to determine whether the use of tuberculin syringes would decrease the pain at the site of injection and also the discomfort of the injection. Materials and Methods: A total of 40 patients who required bilateral therapeutic extraction of upper and lower premolars were selected for the study. The study involved 40 patients of both the genders between the age group of 12 and 26 years of age who reported to the oral surgery outpatient department in October 2017-January 2018. They were divided into two groups of 20 each. Group A: Local anesthesia (LA) administration using a conventional syringe and Group B: LA administration using tuberculin syringes. Pain assessment was done using the visual analog scale, and the results were analyzed using a Chi-square test. Results: A total of 40 patients were studied. Pain associated with the injection in Group B patients (tuberculin syringe) was found to be significantly low, and the results are statistically significant. This study shows that the tuberculin syringes can be used for local infiltration anesthesia administration as they are effective and convenient and do not cause pain during injection. Conclusion: This study concluded that the use of tuberculin syringes shows a significant reduction in the pain during the time of local anesthetic administration. [ABSTRACT FROM AUTHOR]