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Aim: The aim of this study is to determine whether the use of tuberculin syringes would decrease the pain at the site of injection and also the discomfort of the injection. Materials and Methods: A total of 40 patients who required bilateral therapeutic extraction of upper and lower premolars were selected for the study. The study involved 40 patients of both the genders between the age group of 12 and 26 years of age who reported to the oral surgery outpatient department in October 2017-January 2018. They were divided into two groups of 20 each. Group A: Local anesthesia (LA) administration using a conventional syringe and Group B: LA administration using tuberculin syringes. Pain assessment was done using the visual analog scale, and the results were analyzed using a Chi-square test. Results: A total of 40 patients were studied. Pain associated with the injection in Group B patients (tuberculin syringe) was found to be significantly low, and the results are statistically significant. This study shows that the tuberculin syringes can be used for local infiltration anesthesia administration as they are effective and convenient and do not cause pain during injection. Conclusion: This study concluded that the use of tuberculin syringes shows a significant reduction in the pain during the time of local anesthetic administration. [ABSTRACT FROM AUTHOR]

Fast dissolving tablets of freely soluble tramadol hydrochloride and poorly soluble levofloxacin were designed with a view to study the difference in disintegration time, wetting efficiency. In this study, the effects of a natural super disintegrants such as isolated mucilage of Plantago ovata, Hibiscus rosa-sinensis and synthetic super disinegrants like croscarmellose sodium (Ac-di-sol) were compared in the different concentrations (2%-9%) to prepare fast dissolving tablets (FDT) by direct compression method. The blends of all formulations were evaluated for various pre-formulation factors. Tablets were evaluated for weight variation, hardness, disintegration time, drug content, friability and in vitro dissolution. The physicochemical parameters of dried powdered mucilages were studied. The formulations of tramadol prepared with mucilage of Plantago ovata and Hibiscus rosa-sinensis showed disintegration time of 71 sec and 72 sec respectively with 90% drug release within 15 min. Formulations of levofloxacin prepared with mucilage of Plantago ovata and Hibiscus rosa-sinensis showed 72 sec and 75 sec respectively with 90% drug release within 15 min. The results showed that natural super disintegrants found to have better disintegrating property than the most widely used synthetic super disintegrant croscarmellose sodium in the formulations of fast dissolving tablets. The stability studies were conducted as per the ICH guidelines and the formulations were found to be stable. The comparative study of poorly soluble drug levofloxacin and freely soluble drug tramadol hydrochloride did not show any difference in disintegration time or wetting efficiency with natural or synthetic super disintegrants. [ABSTRACT FROM AUTHOR]