1. Potential of yeast secretory vesicles in biodelivery systems.
- Author
-
Kutralam-Muniasamy G, Flores-Cotera LB, and Perez-Guevara F
- Subjects
- Cell Membrane genetics, Cell Membrane metabolism, Chemistry, Pharmaceutical, Genotype, Mutation, Phenotype, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae metabolism, Saccharomyces cerevisiae Proteins genetics, Saccharomyces cerevisiae Proteins metabolism, Drug Carriers, Drug Delivery Systems methods, Exosomes metabolism, Gene Transfer Techniques, Saccharomyces cerevisiae physiology, Secretory Vesicles metabolism
- Abstract
Membranous vesicular organelles (MVOs), such as secretory vesicles and exosomes, perform a variety of biological functions ranging from secretion to cellular communication in eukaryotic cells. Exosomes, particularly those of mammalian cells, have been widely studied as potential carriers in human therapeutic applications. However, no study has yet demonstrated the use of yeast secretory vesicles for such applications. Therefore, we explore here the current state of knowledge on yeast secretory vesicles and their potential use in therapeutic delivery systems. We focus on the characteristics shared by exosomes and yeast secretory vesicles to provide insights into the use of the latter as delivery vehicles. From this perspective, we speculate on the potential application of post-Golgi vesicles (PGVs) in the biomedical field., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF