1. Feasibility of obtaining in situ nanocapsules through modified self-microemulsifying drug delivery systems. A new manufacturing approach for oral route administration
- Author
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Viridiana Gisela Llera-Rojas, L Alicia Del Real, Luz María Melgoza-Contreras, David Quintanar-Guerrero, and Néstor Mendoza-Muñoz
- Subjects
Drug Industry ,Polymers ,Drug Compounding ,Pharmaceutical Science ,Administration, Oral ,Nanotechnology ,02 engineering and technology ,behavioral disciplines and activities ,030226 pharmacology & pharmacy ,Nanocapsules ,Core shell ,Excipients ,03 medical and health sciences ,0302 clinical medicine ,Drug Delivery Systems ,mental disorders ,Drug Discovery ,Oral route ,Particle Size ,Pharmacology ,Drug Carriers ,Chemistry ,Organic Chemistry ,Drug degradation ,021001 nanoscience & nanotechnology ,Bioavailability ,Gastrointestinal Tract ,Drug delivery ,Microscopy, Electron, Scanning ,Feasibility Studies ,Emulsions ,0210 nano-technology - Abstract
Nanocapsules (NCs) are submicron-sized core shell systems which present important advantages such as improvement of drug efficacy and bioavailability, prevention of drug degradation, and provision of controlled-release delivery. The available methods for NC production require expensive recovery and purification steps which compromised the morphology of NCs. Industrial applications of NCs have been avoided due to the aforementioned issues. In this study, we developed a new method based on a modified self-microemulsifying drug delivery system (SMEDDS) for in situ NCs production within the gastrointestinal tract. This new methodology does not require purification and recovery steps and can preserve the morphology and the functionality of NCs. The in situ formed NCs of Eudragit
- Published
- 2017