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Your search keyword '"Zhang, Zhenqiang"' showing total 4 results
Start Over Author "Zhang, Zhenqiang" Journal drug delivery
4 results on '"Zhang, Zhenqiang"'

3. In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration

Author

Zeng, Huahui, primary, Zhu, Xin, additional, Tian, Qikang, additional, Yan, Yinyin, additional, Zhang, Lan, additional, Yan, Min, additional, Li, Ruiqin, additional, Li, Xiaofang, additional, Wang, Guoqiang, additional, Ma, Jinlian, additional, Su, Yufang, additional, Zhang, Xiangbo, additional, Ma, Linyu, additional, Zhang, Zhenqiang, additional, and Wu, Xiangxiang, additional

Published
2020
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4. Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer.

Author

Zeng X, Zhu X, Tian Q, Tan X, Sun N, Yan M, Zhao J, Wu X, Li R, Zhang Z, and Zeng H

Subjects
Animals, Antineoplastic Agents administration & dosage, Apoptosis drug effects, Cell Line, Tumor, Cell Survival drug effects, Chemistry, Pharmaceutical, Drug Liberation, Humans, Mice, Mice, Inbred BALB C, Oligosaccharides chemistry, Particle Size, Pentacyclic Triterpenes administration & dosage, Solubility, Tumor Burden drug effects, Antineoplastic Agents pharmacology, Chitosan chemistry, Pancreatic Neoplasms pathology, Pentacyclic Triterpenes pharmacology
Abstract

Celastrol is a promising antitumor drug candidate, but the poor water solubility and cytotoxicity limit its clinical application. Herein, we synthesized a Celastrol (Cel)-chitosan oligosaccharide (CSO) conjugate (Cel-CSO) for drug delivery. Celastrol was conjugated to a CSO backbone via amide bond formation, which was verified by infrared spectrum (IR) analyses. The Cel-CSO contained ∼10 wt% of Celastrol showed excellent aqueous solubility (18.6 mg/mL) in comparation with the parent Celastrol. Cel-CSO significantly inhibited tumor growth, induced apoptosis, and effectively suppressed tumor metastasis in human pancreatic cancer cells (BxPC-3). While the cytotoxicity of Cel-CSO in hepatic cells (HL7702) was lower than that of the free Celastrol. Cel-CSO enhanced the anticancer efficacy, promoted the circulation time of Celastrol, and reduced the subacute toxicity, which indicated that CSO can be a promising Celastrol delivery system for pancreatic cancer therapy.

Published
2022
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