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Rural areas are often difficult to access reliably with medicine and vaccines. This study aimed to examine rural health care workers’ attitude towards drone delivery for medicine and vaccines and the factors that influenced it. Health care workers from four rural health care facilities were sampled. Participants self-reported their demographic information, attitude towards medicine and vaccine delivery using drones, perception of benefits and risks of using drones, and perceived leadership innovativeness through an online or a pen-and-paper questionnaire. A total of 272 health care workers (mean age = 36.19, SD = 8.10) from all of the sites participated in this study. More than half of the study participants agreed or strongly agreed that using a drone to deliver medicine and vaccines is a good idea (54.2%, 95% CI [47.5, 60.8]), a wise idea (54.6%, 95% CI [47.9, 61.2]), and is desirable (52.5%, 95% CI [45.7, 59.0]). Males (β = 0.223), workers from the Obstetrics and Gynaecology department (β = 0.135), a lower perceived delivery risk (β = −0.237), and higher leadership innovativeness (β = 0.336) predicted positive attitudes towards drone usage. Assistant medical officers (β = −0.172) had a negative attitude. There is a need to further understand the roles of occupation and leadership innovativeness in predicting health care workers’ attitude towards drone usage, as these differences could be embedded within their roles in the health care system.