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Magnetic particles based on superparamagnetic iron oxide nanocrystals find increasing application in the development of modern techniques for high-precision express determination of biomolecule concentrations. In this work, based on an original technique for the ultrasensitive detection of nonlinear magnetic nanomaterials, we develop a universal method for the use of magnetic particles as polyfunctional agents that simultaneously perform several different functions in a single assay for topical tasks of biochemical and medical diagnostics. The method is tested for the rapid quantitative detection of cardiac markers and SARS-CoV-2-associated molecular markers in complex matrices. The proposed method is promising for creating test systems for prehospital monitoring, in particular, emergency molecular diagnostics in patients with a suspected acute myocardial infarction, and the rapid detection of the coronavirus infection. [ABSTRACT FROM AUTHOR]