1. Plasma Interleukin-37 Is Elevated in Patients with Rheumatoid Arthritis: Its Correlation with Disease Activity and Th1/Th2/Th17-Related Cytokines
- Author
-
Bao-hua Qian, Ting Xia, Junjie Wang, Xing-feng Zheng, Ju Zhang, Dong-bao Zhao, He Fang, Zhao-fan Xia, Ya-fei Pang, Lan-ling Zhang, and Xiao-Qing Wei
- Subjects
Adult ,Male ,Article Subject ,medicine.medical_treatment ,Clinical Biochemistry ,Arthritis ,Inflammation ,Pathogenesis ,Arthritis, Rheumatoid ,Interferon-gamma ,Genetics ,medicine ,Humans ,Interferon gamma ,Molecular Biology ,Chemokine CCL2 ,Aged ,Aged, 80 and over ,lcsh:R5-920 ,business.industry ,Tumor Necrosis Factor-alpha ,Biochemistry (medical) ,Interleukin ,Granulocyte-Macrophage Colony-Stimulating Factor ,General Medicine ,T-Lymphocytes, Helper-Inducer ,Middle Aged ,medicine.disease ,Cytokine ,Rheumatoid arthritis ,Case-Control Studies ,Immunology ,Tumor necrosis factor alpha ,Female ,medicine.symptom ,lcsh:Medicine (General) ,business ,Biomarkers ,medicine.drug ,Research Article ,Interleukin-1 - Abstract
Interleukin- (IL-) 37 is a novel anti-inflammatory cytokine that suppresses immune response and inflammation. This study was performed to determine whether IL-37 was elevated in patients with rheumatoid arthritis (RA) and investigate the correlation between IL-37 level and disease activity and the concentration of Th1/Th2/Th17-related cytokines. Clinical parameters of disease activity, including the 28-joint disease activity score (DAS28) and C-reactive protein (CRP), were collected in 34 RA patients and 34 age- and sex-matched healthy controls. Plasma IL-37 was measured by ELISA. Plasma levels of TNF-α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, G-CSF, GM-CSF, IFN-γ, MCP-1, and MIP-1βwere analyzed using the Bio-Plex suspension array system. It was found that IL-37 levels were elevated markedly in RA patients and almost undetectable in healthy controls. In addition, IL-37 levels in patients with active RA were significantly enhanced as compared with those in patients of remission. More importantly, IL-37 showed a significant correlation with disease activity (DAS28) and IL-4, IL-7, IL-10, IL-12, and IL-13 concentrations in RA patients. These findings suggest that IL-37 plays an important role in the pathogenesis of RA and may prove to be a potential biomarker of active RA.
- Published
- 2015