1. Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids
- Author
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Ana Lúcia G. Demarco, Maria de Lourdes V. Rodrigues, José Fernando C. Figueiredo, Neifi Hassam S. Deghaide, Marcelo Bezerra de Menezes, Luís A. Demarco, Ana Paula M. Fernandes, and Eduardo A. Donadi
- Subjects
Adult ,Male ,Clinical Biochemistry ,stomatognathic system ,Genetics ,Humans ,Genetic Predisposition to Disease ,Toxoplasmosis, Ocular ,Molecular Biology ,Alleles ,lcsh:R5-920 ,Acquired Immunodeficiency Syndrome ,toxoplasma gondii ,Biochemistry (medical) ,HIV ,General Medicine ,Middle Aged ,HLA ,AIDS ,Chorioretinitis ,Case-Control Studies ,Disease Progression ,Female ,Other ,HLA-B35 Antigen ,lcsh:Medicine (General) ,Biomarkers ,toxoplasmic retinochoroiditis - Abstract
Background/aims: The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC).Methods: 98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies and without TCR) were studied.Results: The HLA-B35 was significantly increased in TRC group (p= 0.0038).Conclusion: The presence of HLA-B35 may simultaneously predispose to progression to AIDS and TRC.
- Published
- 2012