1. Analysis of N6-Methyladenosine RNA Methylation Regulators in Diagnosis and Distinct Molecular Subtypes of Ankylosing Spondylitis
- Author
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Cheng Zhong, Jia-hua Liang, Zhen Chen, Li-ping Zhong, Guo-dong Sun, Wei-xing Xie, Dong-ping Wang, Wen-de Zhuang, Hao-hua Guo, Da-xiang Jin, and Yu-ming Li
- Subjects
Adenosine ,Article Subject ,Biochemistry (medical) ,Clinical Biochemistry ,Genetics ,Humans ,Spondylitis, Ankylosing ,General Medicine ,RNA, Messenger ,Molecular Biology ,Methylation - Abstract
The most frequent internal modification in eukaryotic mRNA is N6-methyladenosine (m6A). However, what we know about the m6A regulators in Ankylosing spondylitis (AS) is still limited. In our study, eight distinct m6A regulators were selected utilizing Differentially Expressed Gene (DEG) analysis of the Gene Expression Omnibus GSE73754 dataset for making comparisons between AS (Ankylosing spondylitis) and non-AS patients. The random forest model and the nomogram model were used to screen the eight candidate m6A regulators and evaluate their prediction accuracy for the occurrence of AS. Furthermore, based on the selected m6A regulators, the AS patients were divided into two subgroups, and we applied principal component analysis algorithms to calculate their m6A score and evaluate the m6A patterns. Our findings revealed that patients in cluster A were linked to activated CD4 T cell immunity and activated CD8 T cell immunity. With its major contributions in the area of immunology, our research in m6A patterns may benefit the future diagnosis and treatment strategies of AS.
- Published
- 2022