1. Mechanisms and efficacy of vismodegib in the treatment of basal cell carcinoma.
- Author
-
Amin SH, Motamedi KK, Ochsner MC, Song TE, and Hybarger CP
- Subjects
- Anilides administration & dosage, Clinical Trials as Topic, Humans, Male, Pyridines administration & dosage, Anilides therapeutic use, Carcinoma, Basal Cell drug therapy, Pyridines therapeutic use
- Abstract
Historically patients with advanced basal cell carcinoma have been subjected to large surgical resections for the treatment of their disease. However, with the development of vismodegib, a first in class molecule that acts to inhibit the hedgehog pathway, patients with advanced and metastatic basal cell carcinoma may have renewed hope in limiting the morbidity involved with surgery. Preliminary data shows a relatively good safety profile and promising results, although further research remains to be conducted. Current progress on utilization of vismodegib for the treatment of advanced basal cell carcinoma is reviewed in this article. Only literature with objective clinical evidence was included in this review.
- Published
- 2013