Objectives:Health-care workers (HCWs) are vulnerable to the risk of coronavirus disease 2019 (COVID-19) infections, and the safety of HCWs is important in situations where a prolonged COVID-19 is expected.Methods:HCWs were recently put in great danger around the globe; as of December 21, there were 306 confirmed cases in HCWs in South Korea, representing 0.60% of the total 50,591 confirmed cases nationally.Results:After experiencing Middle East respiratory syndrome (MERS), South Korea has put a range of infection prevention and control (IPC) measures with long-term perspectives in place, including the use of personal protective equipment (PPE), HCW’s infection status tracing, visitor control, and a variety of supports from both national and local public health authorities.Conclusions:This article introduces the infection status of HCWs and IPC measures currently taken in South Korea, emphasizing the collaborative and long-term IPC efforts for ensuring the safety of HCWs.