1. The Accuracy of Sonography in Predicting Steatosis and Fibrosis in Chronic Hepatitis C
- Author
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Chien-Hua Chen, Chien-Long Kuo, Yung-Hsiang Yeh, Shang-Tao Lin, Chiu-Kue Nien, and Chi-Chieh Yang
- Subjects
Adult ,Liver Cirrhosis ,Male ,medicine.medical_specialty ,Physiology ,Biopsy ,Sensitivity and Specificity ,Gastroenterology ,Predictive Value of Tests ,Fibrosis ,Internal medicine ,medicine ,Humans ,Aged ,Retrospective Studies ,Ultrasonography ,Chi-Square Distribution ,medicine.diagnostic_test ,business.industry ,Fatty liver ,Hepatitis C ,Hepatitis C, Chronic ,Middle Aged ,Hepatology ,medicine.disease ,Fatty Liver ,Predictive value of tests ,Liver biopsy ,Female ,Steatosis ,business ,Hepatic fibrosis - Abstract
The accuracy and clinical significance of sonography (US) in demonstrating fatty liver and hepatic fibrosis in chronic hepatitis C (CHC) are rarely reported. US had sensitivity 71.1%, specificity 72.9%, 58.7% positive predictive value (PPV), and 82.3% negative predictive value (NPV) in demonstrating histological steatosis > or =5%. US had sensitivity 85.7%, specificity 60.4%, 13% PPV, and 98.4% NPV in demonstrating histological steatosis > or =30% with clinical significance in predicting prognosis and therapeutic response in CHC. Subjects with fatty liver on US had a greater prevalence of body mass index (BMI) > or =25 kg/m2, inflammation-necrosis grade >2, and total bilirubin
- Published
- 2007