1. Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease.
- Author
-
Klemenak, Martina, Dolinšek, Jernej, Langerholc, Tomaž, Di Gioia, Diana, Mičetić-Turk, Dušanka, Dolinšek, Jernej, Langerholc, Tomaž, and Mičetić-Turk, Dušanka
- Abstract
Background: Increasing evidence suggests that not only genetics, but also environmental factors like gut microbiota dysbiosis play an important role in the pathogenesis of celiac disease (CD).Aim: The aim of our study was to investigate the effect of two probiotic strains Bifidobacterium breve BR03 and B. breve B632 on serum production of anti-inflammatory cytokine interleukin 10 (IL-10) and pro-inflammatory cytokine tumor necrosis factor alpha (TNF-α) in children with CD.Methods: The study was a double-blinded, placebo-controlled trial that included 49 children with CD on gluten-free diet (GFD) randomized into two groups and 18 healthy children in the control group. The first group (24 children with CD) daily received B. breve BR03 and B632 (2 × 10(9) colony-forming units) and the second group (25 children with CD) received placebo for 3 months.Results: TNF-α levels were significantly decreased in the first group after receiving B. breve for 3 months. On follow-up, 3 months after receiving probiotics, TNF-α levels increased again. Children with CD who were on GFD for less than 1 year showed similar baseline TNF-α levels as children who were on GFD for more than 1 year. IL-10 levels were in all groups of patients below detection level.Conclusions: Probiotic intervention with B. breve strains has shown a positive effect on decreasing the production of pro-inflammatory cytokine TNF-α in children with CD on GFD. [ABSTRACT FROM AUTHOR]- Published
- 2015
- Full Text
- View/download PDF