1. LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy.
- Author
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Tarabra E, Pazienza P, Borghesio E, Actis GC, Tappero G, Framarin L, Ayoubi M, Castellino F, Leone N, Sansoè G, De Paolis P, Comandone A, and Rosina F
- Subjects
- Biomarkers, Tumor genetics, Biomarkers, Tumor metabolism, Colorectal Neoplasms epidemiology, Colorectal Neoplasms genetics, Female, Genotype, Humans, Incidence, Italy epidemiology, Lactase metabolism, Lactose Intolerance complications, Lactose Intolerance enzymology, Male, Middle Aged, Prognosis, Retrospective Studies, Risk Factors, Colorectal Neoplasms etiology, DNA, Neoplasm genetics, Lactase genetics, Lactose Intolerance genetics, Polymorphism, Genetic
- Abstract
Background: The activity of epithelial lactase (LCT) associates with a polymorphism 13910 bp upstream the LCT-encoding gene (LCT-13910C>T). The relationship between LCT-13910C>T polymorphism and risk for colorectal cancer is unclear., Aims: We examined the relationship between the LCT-13910C>T polymorphism causing lactose intolerance and risk for colorectal cancer/polyps onset in the Italian population., Patients and Methods: 793 subjects (306 with colorectal cancer, 176 with polyps and 311 controls) were genotyped for the LCT-13910C>T variant by TaqMan real time-PCR., Results: Lactose malabsorption linked to the CC genotype did not associate with an increased risk for either colorectal cancer (OR=1.041; 95% CI=0.751-1.442; p=0.868) or polyps (OR=0.927; 95% CI=0.630-1.363; p=0.769). There was no association with colorectal cancer/polyps site. 60% of the subjects overall bore the CC genotype., Conclusion: In the Italian population the LCT-13910C>T polymorphism is not associated to the risk for colorectal cancer or polyps., (Copyright 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2010
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