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1. Risk of COVID 19 in patients with inflammatory bowel diseases compared to a control population

Author

Maconi, Giovanni, Bosetti, Cristina, De Monti, Alberta, Boyapati, Ray Kiran, Shelton, Edward, Piazza, Nicole, Carvalhas Gabrielli, Anna Maria, Lenti, Marco Vincenzo, Bezzio, Cristina, Ricci, Chiara, Greco, Salvatore, Romeo, Samanta, Giangregorio, Francesco, Gridavilla, Daniele, Tagliani, Fabio, Massari, Alessandro, Pastorelli, Luca, Di Sabatino, Antonio, Saibeni, Simone, Alicante, Saverio, Ferretti, Francesca, Rizzardini, Giuliano, Galli, Massimo, and Ardizzone, Sandro

Published
2021
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2. Impact of COVID-19 pandemic on the management of paediatric inflammatory bowel disease: An Italian multicentre study on behalf of the SIGENP IBD Group

Author

Arrigo, Serena, Alvisi, Patrizia, Banzato, Claudia, Bramuzzo, Matteo, Celano, Rosaria, Civitelli, Fortunata, D'Arcangelo, Giulia, Dilillo, Anna, Dipasquale, Valeria, Felici, Enrico, Fuoti, Maurizio, Gatti, Simona, Knafelz, Daniela, Lionetti, Paolo, Mario, Federica, Marseglia, Antonio, Martelossi, Stefano, Moretti, Chiara, Norsa, Lorenzo, Panceri, Roberto, Renzo, Sara, Romano, Claudio, Romeo, Erminia, Strisciuglio, Caterina, and Martinelli, Massimo

Published
2021
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3. Management of paediatric IBD after the peak of COVID-19 pandemic in Italy: A position paper on behalf of the SIGENP IBD working group

Author

Arrigo, Serena, Alvisi, Patrizia, Banzato, Claudia, Bramuzzo, Matteo, Civitelli, Fortunata, Corsello, Antonio, D'Arcangelo, Giulia, Dilillo, Anna, Dipasquale, Valeria, Felici, Enrico, Fuoti, Maurizio, Gatti, Simona, Giusti, Zeno, Knafelz, Daniela, Lionetti, Paolo, Mario, Federica, Marseglia, Antonio, Martelossi, Stefano, Moretti, Chiara, Norsa, Lorenzo, Nuti, Federica, Panceri, Roberto, Rampado, Stefania, Renzo, Sara, Romano, Claudio, Romeo, Erminia, Strisciuglio, Caterina, and Martinelli, Massimo

Published
2021
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4. OC.11.2: RED CELL DISTRIBUTION WIDTH (RDW) TO PLATELET RATIO (RDW/PLT RATIO) ACCURATELY PREDICTS 7-YEAR DECOMPENSATION AND MODALITIES OF DISEASE PROGRESSION IN COMPENSATED ADVANCED CHRONIC LIVER DISEASE: A PRELIMINARY OBSERVATION [THE REPLAY STUDY]

Author

Romeo, M., primary, Cipullo, M., additional, Vaia, P., additional, Auletta, S., additional, Niosi, M., additional, Di Nardo, F., additional, Napolitano, C., additional, Zagaria, G., additional, Dallio, M., additional, and Federico, A., additional

Published
2024
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5. T.07.1: PREVALENCE OF DYSGEUSIA IN PATIENTS WITH ADVANCED CHRONIC LIVER DISEASE (ACLD), RELATIONSHIP WITH THE LIVER-DISEASE PROGRESSION STATUS, AND IMPACT ON MALNUTRITION-SARCOPENIA-FRAILTY (THE PREDYCI STUDY)

Author

Romeo, M., primary, Cipullo, M., additional, Coppola, A., additional, Iadanza, G., additional, Vaia, P., additional, Olivieri, S., additional, Pellegrino, R., additional, Gravina, A.G., additional, Dallio, M., additional, and Federico, A., additional

Published
2024
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8. T.04.8: IBD PATIENTS SHOW WORRYING LEVELS OF SELF-REPORTED PHYSICAL INACTIVITY AS MEASURED BY THE INTERNATIONAL PHYSICAL ACTIVITY QUESTIONNAIRE INDEPENDENTLY OF DISEASE ACTIVITY AND IBD PHENOTYPE: RESULTS FROM THE EXTENDED “BE-FIT-IBD” CROSS-SECTIONAL STUDY

Author

Gravina, A.G., primary, Pellegrino, R., additional, Palladino, G., additional, Imperio, G., additional, D'Onofrio, R., additional, Arboretto, G., additional, Romeo, M., additional, Ciamarra, P., additional, Dallio, M., additional, and Federico, A., additional

Published
2024
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10. Programmed cell death 1 genetic variant and liver damage in nonalcoholic fatty liver disease

Author

Rosaria M. Pipitone, Francesco Malvestiti, Grazia Pennisi, Oveis Jamialahmadi, Paola Dongiovanni, Giorgio Bertolazzi, Jussi Pihlajamäki, Hannele Yki‐Järvinen, Umberto Vespasiani‐Gentilucci, Federica Tavaglione, Samantha Maurotti, Cristiana Bianco, Gabriele Di Maria, Marco Enea, Anna L. Fracanzani, Vesa Kärjä, Giulia Lupo, Ville Männistö, Marica Meroni, Roberto Piciotti, Sami Qadri, Rossella Zito, Antonio Craxì, Vito Di Marco, Calogero Cammà, Claudio Tripodo, Luca Valenti, Stefano Romeo, Salvatore Petta, Stefania Grimaudo, Pipitone, Rosaria M, Malvestiti, Francesco, Pennisi, Grazia, Jamialahmadi, Ovei, Dongiovanni, Paola, Bertolazzi, Giorgio, Pihlajamäki, Jussi, Yki-Järvinen, Hannele, Vespasiani-Gentilucci, Umberto, Tavaglione, Federica, Maurotti, Samantha, Bianco, Cristiana, Di Maria, Gabriele, Enea, Marco, Fracanzani, Anna L, Kärjä, Vesa, Lupo, Giulia, Männistö, Ville, Meroni, Marica, Piciotti, Roberto, Qadri, Sami, Zito, Rossella, Craxì, Antonio, Di Marco, Vito, Cammà, Calogero, Tripodo, Claudio, Valenti, Luca, Romeo, Stefano, Petta, Salvatore, and Grimaudo, Stefania

Subjects
Settore MED/12 - Gastroenterologia, Hepatology, Settore BIO/13 - Biologia Applicata, Gastroenterology, CXCR6, NAFLD, NASH, PDCD1, checkpoint inhibitors
Abstract

Background and aims: Programmed cell death 1/programmed cell death-ligand 1 (PD-1/PDL-1) axis has been reported to modulate liver inflammation and progression to hepatocellular carcinoma (HCC) in patients with nonalcoholic fatty liver disease (NAFLD). Here, we examined whether the PDCD1 variation is associated with NAFLD severity in individuals with liver biopsy. Methods: We examined the impact of PDCD1 gene variants on HCC, as robust severe liver disease phenotype in UK Biobank participants. The strongest genetic association with the rs13023138 G>C variation was subsequently tested for association with liver damage in 2889 individuals who underwent liver biopsy for suspected nonalcoholic steatohepatitis (NASH). Hepatic transcriptome was examined by RNA-Seq in a subset of NAFLD individuals (n = 121). Transcriptomic and deconvolution analyses were performed to identify biological pathways modulated by the risk allele. Results: The rs13023138 C>G showed the most robust association with HCC in UK Biobank (p = 5.28E-4, OR = 1.32, 95% CI [1.1, 1.5]). In the liver biopsy cohort, rs13023138 G allele was independently associated with severe steatosis (OR 1.17, 95% CI 1.02-1.34; p = .01), NASH (OR 1.22, 95% CI 1.09-1.37; p C allele was linked to higher hepatic representation of M1 macrophages, paralleled by upregulation of pathways related to inflammation and higher expression of CXCR6. Conclusions: The PDCD1 rs13023138 G allele was associated with HCC development in the general population and with liver disease severity in patients at high risk of NASH.

Published
2023
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12. T.03.3 THE INFLUENCE OF SUPERIMPOSED SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS-2 (SARS-COV-2) LIFESTYLE CHANGES ON NON-ALCOHOLIC FATTY LIVER DISEASE EVOLUTION: A MATTER OF BODY COMPOSITION: A MULTICENTER CLINICAL STUDY

Author

Romeo, M., primary, Cipullo, M., additional, Zagaria, G., additional, Ventriglia, L., additional, Scognamiglio, F., additional, Iadanza, G., additional, Olivieri, S., additional, Coppola, A.C., additional, Dallio, M., additional, Sangineto, M., additional, Serviddio, G., additional, and Federico, A., additional

Published
2023
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13. A functional interaction between hepatic estrogen receptor-α and PNPLA3 p.I148M inherited variant drives fatty liver disease susceptibility in women

Author

Cherubini, A., primary, Ostadreza, M., additional, Jamialahmadi, O., additional, Pelusi, S., additional, Rrapaj, E., additional, Casirati, E., additional, Passignani, G., additional, Baselli, G., additional, Ronzoni, L., additional, Dongiovanni, P., additional, Prati, D., additional, Romeo, S., additional, and Valenti, L., additional

Published
2023
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15. Programmed cell death 1 genetic variant and liver damage in nonalcoholic fatty liver disease

Author

Pipitone, R.M., primary, Malvestiti, F., additional, Pennisi, G., additional, Jamialahmadi, O., additional, Dongiovanni, P., additional, Bertolazzi, G., additional, Pihlajamäki, J., additional, Yki-Järvinen, H., additional, Vespasiani-Gentilucci, U., additional, Tavaglione, F., additional, Maurotti, S., additional, Bianco, C., additional, Di Maria, G., additional, Enea, M., additional, Fracanzani, A.L., additional, Kärjä, V., additional, Lupo, G., additional, Männistö, V., additional, Meroni, M., additional, Piciotti, R., additional, Qadri, S., additional, Zito, R., additional, Craxì, A., additional, Di Marco, V., additional, Cammà, C., additional, Tripodo, C., additional, Valenti, L., additional, Romeo, S., additional, Petta, S., additional, and Grimaudo, S., additional

Published
2023
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17. OC.08.5 THE ALPHA-GLUTATHIONE-S-TRANSFERASE (ALPHAGST) AND THE “METABOLIC ABNORMALITIES-AST/PLATELET RATIO-INFLAMMATION-ALPHAGST”(MARINA)-INDEX AS A NOVEL PREDICTIVE BIOMARKER AND COMPOSITE TOOL OF HEPATOPATHY PROGRESSION IN PATIENTS WITH MAFLD

Author

Romeo, M., primary, Dallio, M., additional, Cipullo, M., additional, Scognamiglio, F., additional, Ventriglia, L., additional, Olivieri, S., additional, Iadanza, G., additional, Zagaria, G., additional, Vitale, L.M., additional, and Federico, A., additional

Published
2023
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20. OC.08.1 PROGRAMMED CELL DEATH 1 GENETIC VARIANT AND LIVER DAMAGE IN NONALCOHOLIC FATTY LIVER DISEASE

Author

Pipitone, R.M., primary, Malvestiti, F., additional, Pennisi, G., additional, Jamialahmadi, O., additional, Dongiovanni, P., additional, Bertolazzi, G., additional, Pihlajamaki, J., additional, Yki-Jarvinen, H., additional, Vespasiani-Gentilucci, U., additional, Tavaglione, F., additional, Maurotti, S., additional, Bianco, C., additional, Di Maria, G., additional, Enea, M., additional, Fracanzani, A., additional, Karja, V., additional, Lupo, G., additional, Mannisto, V., additional, Meroni, M., additional, Piciotti, R., additional, Qadri, S., additional, Zito, R., additional, Craxi, A., additional, Di Marco, V., additional, Camma, C., additional, Tripodo, C., additional, Valenti, L., additional, Romeo, S., additional, Petta, S., additional, and Grimaudo, S., additional

Published
2023
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30. Management of paediatric IBD after the peak of COVID-19 pandemic in Italy: A position paper on behalf of the SIGENP IBD working group

Author

Federica Mario, Federica Nuti, Chiara Moretti, Claudia Banzato, Lorenzo Norsa, Stefano Martelossi, Claudio Romano, Caterina Strisciuglio, Sara Renzo, Antonio Corsello, Maurizio Fuoti, Massimo Martinelli, Anna Dilillo, Zeno Giusti, Paolo Lionetti, Simona Gatti, Valeria Dipasquale, Fortunata Civitelli, Erminia Romeo, A. Marseglia, Enrico Felici, Matteo Bramuzzo, Roberto Panceri, Stefania Rampado, Serena Arrigo, Patrizia Alvisi, Daniela Knafelz, Giulia D'Arcangelo, Arrigo, Serena, Alvisi, Patrizia, Banzato, Claudia, Bramuzzo, Matteo, Civitelli, Fortunata, Corsello, Antonio, D'Arcangelo, Giulia, Dilillo, Anna, Dipasquale, Valeria, Felici, Enrico, Fuoti, Maurizio, Gatti, Simona, Giusti, Zeno, Knafelz, Daniela, Lionetti, Paolo, Mario, Federica, Marseglia, Antonio, Martelossi, Stefano, Moretti, Chiara, Norsa, Lorenzo, Nuti, Federica, Panceri, Roberto, Rampado, Stefania, Renzo, Sara, Romano, Claudio, Romeo, Erminia, Strisciuglio, Caterina, Martinelli, Massimo, Arrigo, S., Alvisi, P., Banzato, C., Bramuzzo, M., Civitelli, F., Corsello, A., D'Arcangelo, G., Dilillo, A., Dipasquale, V., Felici, E., Fuoti, M., Gatti, S., Giusti, Z., Knafelz, D., Lionetti, P., Mario, F., Marseglia, A., Martelossi, S., Moretti, C., Norsa, L., Nuti, F., Panceri, R., Rampado, S., Renzo, S., Romano, C., Romeo, E., Strisciuglio, C., and Martinelli, M.

Subjects
2019-20 coronavirus outbreak, medicine.medical_specialty, COVID-19, Inflammatory bowel disease, Paediatrics, SARS-CoV2, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Guidelines, Inflammatory bowel disease, Pediatrics, Disease course, 03 medical and health sciences, 0302 clinical medicine, Pandemic, Medicine, Humans, Intensive care medicine, Child, Hepatology, business.industry, SARS-CoV-2, Gastroenterology, Outbreak, COVID-19, Paediatrics, medicine.disease, Inflammatory Bowel Diseases, Organizational Innovation, Italy, Paediatric, 030220 oncology & carcinogenesis, Communicable Disease Control, Position paper, 030211 gastroenterology & hepatology, Risk Adjustment, business, Human
Abstract

Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2, spreading in Italy during the first months of 2020, abruptly changed the way of practicing medicine in this country. As a consequence of the lockdown, the diagnostic and therapeutic management of paediatric chronic conditions, such as inflammatory bowel disease (IBD) has been affected. During the peak of COVID-19 pandemic, elective visits, endoscopies and infusions have been postponed, with potential clinical and psychological impact on disease course and a high likelihood of increasing waiting lists. While slowly moving back towards normality, clinicians need to recognize the best ways to care for patients with IBD, carefully avoiding risk factors for new potential epidemic outbreaks. In this uncertain scenario until the development and spread of COVID-19 vaccine, it is necessary to continue to operate with caution. Hereby we provide useful indications for a safer and gradual restarting of routine clinical activities after COVID-19 peak in Italy.

Published
2020

32. OC.08.1 PROGRAMMED CELL DEATH 1 GENETIC VARIANT AND LIVER DAMAGE IN NONALCOHOLIC FATTY LIVER DISEASE

Author

R.M. Pipitone, F. Malvestiti, G. Pennisi, O. Jamialahmadi, P. Dongiovanni, G. Bertolazzi, J. Pihlajamaki, H. Yki-Jarvinen, U. Vespasiani-Gentilucci, F. Tavaglione, S. Maurotti, C. Bianco, G. Di Maria, M. Enea, A. Fracanzani, V. Karja, G. Lupo, V. Mannisto, M. Meroni, R. Piciotti, S. Qadri, R. Zito, A. Craxi, V. Di Marco, C. Camma, C. Tripodo, L. Valenti, S. Romeo, S. Petta, and S. Grimaudo

Subjects
Hepatology, Gastroenterology
Published
2023
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36. A new high-throughput HBV integration sequencing approach shows that mitochondrial DNA is frequently targeted by virus integration in liver cells with active HBV replication

Author

Giosa, D., primary, Lombardo, D., additional, Musolino, C., additional, Chines, V., additional, Raffa, G., additional, Casuscelli di Tocco, F., additional, D'Aliberti, D., additional, Saitta, C., additional, Alibrandi, A., additional, Aiese Cigliano, R., additional, Romeo, O., additional, Navarra, G., additional, Raimondo, G., additional, and Pollicino, T., additional

Published
2022
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41. OC-08Rare ATG7 genetic variants predispose to severe fatty liver disease

Author

Bianco, C., primary, Malvestiti, F., additional, Baselli, G.A., additional, Jamialahmadi, O., additional, Pelusi, S., additional, Ciociola, E., additional, Dongiovanni, P., additional, Maggioni, M., additional, Tavaglione, F., additional, Cespiati, A., additional, Mancina, R.M., additional, D'Ambrosio, R., additional, Petta, S., additional, Miele, L., additional, Gentilucci, U. Vespasiani, additional, Federico, A., additional, Pihlajamaki, J., additional, Bugianesi, E., additional, Fracanzani, A.L., additional, Reeves, H., additional, Soardo, G., additional, Prati, D., additional, Romeo, R., additional, and Valenti, L.V.C., additional

Published
2021
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48. AF.86 THE ANALYSIS OF ALCOHOL CONSUMPTION DURING THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 ITALIAN LOCKDOWN

Author

C. Mazzarella, A. Spina, Antonietta Gerarda Gravina, Alessandro Federico, Carmela Loguercio, Marcello Dallio, and Mario Romeo

Subjects
2019-20 coronavirus outbreak, Hepatology, Coronavirus disease 2019 (COVID-19), Liver, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Gastroenterology, Medicine, business, Virology, Alcohol consumption, Abstracts of the 27th National Congress of Digestive Diseases 2021 – FISMAD
Published
2021

49. AF.135 USE OF PERORAL CHOLANGIOSCOPY IN THE DIAGNOSIS OF INDETERMINATE STENOSIS: A MULTI-CENTRE EXPERIENCE

Author

E. Borina, G. Melita, Giuseppe Conoscenti, F. Romeo, A. Tortora, Socrate Pallio, Dario Raimondo, Francesca Rossi, Giancarlo Pompei, Ilaria Tarantino, A. Santagati, and Emanuele Sinagra

Subjects
medicine.medical_specialty, Stenosis, Hepatology, business.industry, Gastroenterology, Medicine, Radiology, Multi centre, Indeterminate, business, medicine.disease
Published
2021
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50. Risk of COVID 19 in patients with inflammatory bowel diseases compared to a control population

Author

Chiara Ricci, Francesca Ferretti, Marco Vincenzo Lenti, Luca Pastorelli, Alessandro Massari, Massimo Galli, Simone Saibeni, Nicole Piazza, F. Giangregorio, Samanta Romeo, Fabio Tagliani, Ray Boyapati, Cristina Bosetti, S. Greco, Sandro Ardizzone, Alberta De Monti, Anna Maria Carvalhas Gabrielli, Giovanni Maconi, Antonio Di Sabatino, Edward Shelton, Saverio Alicante, Giuliano Rizzardini, Cristina Bezzio, and Daniele Gridavilla

Subjects
Adult, Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Gastrointestinal Diseases, Severe disease, Inflammatory bowel disease, Population control, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Prevalence, medicine, Humans, In patient, Hepatology, Alimentary Tract, SARS-CoV-2, business.industry, Gastroenterology, Inflammatory Bowel Diseases, COVID-19, Middle Aged, medicine.disease, digestive system diseases, Symptoms, Hospitalization, Increased risk, Italy, Case-Control Studies, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Observational study, business
Abstract

Background It is unclear whether patients with inflammatory bowel disease (IBD) are at increased risk of COVID-19. Objectives This observational study compared the prevalence of COVID-19 symptoms, diagnosis and hospitalization in IBD patients with a control population with non-inflammatory bowel disorders. Methods This multicentre study, included 2733 outpatients (1397 IBD patients and 1336 controls), from eight major gastrointestinal centres in Lombardy, Italy. Patients were invited to complete a web-based questionnaire regarding demographic, historical and clinical features over the previous 6 weeks. The prevalence of COVID-19 symptoms, diagnosis and hospitalization for COVID-19 was assessed. Results 1810 patients (64%) responded to the questionnaire (941 IBD patients and 869 controls). IBD patients were significantly younger and of male sex than controls. NSAID use and smoking were more frequent in controls. IBD patients were more likely treated with vitamin-D and vaccinated for influenza. Highly probable COVID-19 on the basis of symptoms and signs was less frequent in the IBD group (3.8% vs 6.3%; OR:0.45, 95%CI:0.28–0.75). IBD patients had a lower rate of nasopharyngeal swab-PCR confirmed diagnosis (0.2% vs 1.2%; OR:0.14, 95%CI:0.03–0.67). There was no difference in hospitalization between the groups (0.1% vs 0.6%; OR:0.14, 95%CI:0.02–1.17). Conclusion IBD patients do not have an increased risk of COVID-19 specific symptoms or more severe disease compared with a control group of gastroenterology patients.

Published
2020

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