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Start Over Author "Maria Letizia Bacchi" Journal digestive and liver disease
7 results on '"Maria Letizia Bacchi"'

2. IL28 polymorphism and HCC after DAAs for chronic hepatitis C

Author

F. Davide, A. Porro, Franco Bazzoli, Francesco Azzaroli, Maria Letizia Bacchi-Reggiani, Giuseppe Mazzella, A. Simili, Federico Ravaioli, Simili, A., Mazzella, G., Ravaioli, F., Davide, F., Bacchi-Reggiani, M.L., Porro, A., Bazzoli, F., and Azzaroli, F.

Subjects
medicine.medical_specialty, Hepatology, Chronic hepatitis, Polymorphism (materials science), business.industry, Internal medicine, IL28, Gastroenterology, medicine, HCC, business, DAA
Published
2018

3. The role of liver and spleen stiffness measurement in predicting hepatic decompensation after HCV eradication with direct-acting antiviral agents therapy

Author

Giuseppe Mazzella, Mariarosa Tamè, Maria Letizia Bacchi-Reggiani, Agostino Colli, Antonio Colecchia, Davide Festi, Federico Ravaioli, Giovanni Marasco, Stefano Brillanti, Elton Dajti, Francesco Azzaroli, and Luigina Vanessa Alemanni

Subjects
medicine.medical_specialty, medicine.anatomical_structure, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Spleen, business, Direct acting, Hepatic decompensation
Published
2019

4. Spleen stiffness measurement: A useful prognostic tool in HCV patients treated with DAAs regimens

Author

Federico Ravaioli, Giuseppe Mazzella, A. Porro, Giovanni Marasco, Davide Festi, Antonio Colecchia, Federica Buonfiglioli, Maria Letizia Bacchi Reggiani, Stefano Brillanti, Ravaioli, F., Marasco, G., Bacchi Reggiani, M.L., Mazzella, G., Buonfiglioli, F., Porro, A., Brillanti, S., Colecchia, A., and Festi, D.

Subjects
medicine.medical_specialty, FibroScan, Hepatology, Hepatocellular carcinoma, business.industry, cirrhosis, Gastroenterology, Stiffness, Spleen, Surgery, medicine.anatomical_structure, Internal medicine, medicine, medicine.symptom, business, cirrhosi
Published
2017

5. PPAR-alpha gene haplotypes in gallstone patients: Prevalence and gender associations

Author

Giuseppe Mazzella, Marco Montagnani, Enrico Roda, Antonio Colecchia, Maria Letizia Bacchi-Reggiani, E. Ravaioli, Francesco Azzaroli, Rita Aldini, R. Righetti, E. Minni, and Davide Festi

Subjects
Genetics, chemistry.chemical_classification, Hepatology, chemistry, business.industry, Haplotype, Gastroenterology, Peroxisome proliferator-activated receptor, Medicine, business, Gene
Published
2006

7. OC.10.7: SPLEEN STIFFNESS MEASUREMENT: A NEW NON INVASIVE PREDICTOR OF PORTAL HYPERTENSION AND ESOPHAGEAL VARICES IN VIRAL CHRONIC LIVER DISEASE

Author

Laura Turco, Antonio Colecchia, A.R. Di Biase, Eleonora Scaioli, Ramona Schiumerini, Giuseppe Mazzella, L. Montrone, Maria Letizia Bacchi-Reggiani, and Davide Festi

Subjects
Sorafenib, medicine.medical_specialty, Cirrhosis, Hepatology, Combination therapy, business.industry, General surgery, Gastroenterology, medicine.disease, Chronic liver disease, BCLC Stage, Esophageal varices, Internal medicine, medicine, Etiology, Portal hypertension, business, medicine.drug
Abstract

to international guidelines. Moreover the effectiveness of AASLD guidelines application has never been prospectively addressed. This is a prospective survey on a large cohort of newly diagnosed HCC observed in the last 2 years. Material and methods: From September 2008 to September 2010, 710 consecutive patients with HCC referring to 30 non-tertiary referral Hospitals were included. Inclusion criteria were newly detected HCC and cirrhosis. Patients were classified according to Child-Pugh and Meld score and BCLC stage. No prefixed protocols on diagnosis and treatment of HCC were operative. Statistical analysis is based on the first 536 cases. Results: Mean age was 70±4.7 yrs (71% M). Comorbidities were present in 322 patients (76%). Prevalent etiology was HCV (56%). Cirrhosis was Child A in 266 (63%), B in 125 (29%) and mean MELD score was 9.5±5.3. The mean size of nodules was 3.8±2.3 cm, monofocal in 57% and paucifocal in 23% cases. Age > 70 yrs and moderate/severe comorbidities were equally distributed among different BCLC stages. Regular follow-up was recorded in 289 cases (54%). Early HCC was more frequently observed in patients on regular follow-up (71% vs 39%). The most frequently employed imaging technique for diagnosis of HCC was TC (93%) followed by CEUS (62%); MRI was utilized in 17% of cases. Adherence to the non-invasive diagnostic criteria was 59% in nodules = 2 cm and 97% in larger nodules. The overall adherence to BCLC treatment algorithm was 52%. Ratio between ideal and real treatment offered was: OLT 42/9, resection 78/36, ablation 160/152, TACE 129/159, Sorafenib 67/21, palliative 60/134. In 25 cases combination therapy was performed. In particular 119 (40%) patients in BCLC stage A did not receive curative therapies. Conclusions: This translational study showed that adherence to either diagnostic and therapeutic AASLD 2005 algorithms was low particularly in early HCC stages. These discrepancies are mainly due to: 1) the difficulty in applying the algorithms in routine clinical practice and 2) the high prevalence of patients > 70 yrs with relevant comorbidities. The effectiveness of AASLD guidelines application remains to be verified.

Published
2011

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