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Your search keyword '"Marchesini, G."' showing total 44 results
Start Over Author "Marchesini, G." Journal digestive and liver disease
44 results on '"Marchesini, G."'

5. OC.05.5 OBETICHOLIC ACID TREATMENT IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS: A SECONDARY ANALYSIS OF THE REGENERATE STUDY ACROSS FIBROSIS STAGES

Author

Sanyal, A.J., primary, Ratziu, V., additional, Loomba, R., additional, Rinella, M., additional, Anstee, Q.M., additional, Goodman, Z., additional, Bedossa, P., additional, Khalili, M., additional, Boursier, J., additional, Stinton, L., additional, Marchesini, G., additional, Allison, M., additional, George, J., additional, Arkkila, P., additional, Bugianesi, E., additional, Zaru, L., additional, Macconell, L., additional, Shringarpure, R., additional, and Younossi, Z., additional

Published
2020
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6. Obeticholic Acid Treatment in Patients with Non-Alcoholic Steatohepatitis: A Secondary Analysis of the Regenerate Study Across Fibrosis Stages

Author

Sanyal, A.J., primary, Ratziu, V., additional, Loomba, R., additional, Rinella, M., additional, Anstee, Q.M., additional, Goodman, Z., additional, Bedossa, P., additional, Khalili, M., additional, Boursier, J., additional, Stinton, L., additional, Marchesini, G., additional, Allison, M., additional, George, J., additional, Arkkila, P., additional, Bugianesi, E., additional, Zaru, L., additional, MacConell, L., additional, and Shringarpure, R., additional

Published
2020
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17. OC.03.2 THE PRESENCE OF WHITE MATTER LESIONS IS ASSOCIATED WITH THE HISTOLOGICAL SEVERITY OF NON-ALCOHOLIC FATTY LIVER DISEASE

Author

Petta, S., primary, Tuttolomondo, A., additional, Gagliardo, C., additional, Zafonte, R., additional, Brancatelli, G., additional, Cabibi, D., additional, Camma, C., additional, Della Corte, V., additional, Di Marco, V., additional, Galvano, L., additional, La Tona, G., additional, Licata, A., additional, Magliozzo, F., additional, Maida, C., additional, Marchesini, G., additional, Merlino, G., additional, Midiri, M., additional, Parrinello, G., additional, Torres, D., additional, Pinto, A., additional, and Craxi, A., additional

Published
2016
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19. The presence of white matter lesions is associated with the histological severity of non-alcoholic fatty liver disease

Author

Petta, S., primary, Tutolomondo, A., additional, Gagliardo, C., additional, Zafonte, R., additional, Brancatelli, G., additional, Cabibi, D., additional, Cammà, C., additional, Di Marco, V., additional, Galvano, L., additional, Licata, A., additional, Magliozzo, F., additional, Marchesini, G., additional, Merlino, G., additional, Parrinello, G., additional, La Tona, G., additional, Torres, D., additional, Midiri, M., additional, Pinto, A., additional, and Craxì, A., additional

Published
2015
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21. P.11.2 PNPLA3 GG GENOTYPE IS ASSOCIATED WITH CAROTID ATHEROSCLEROSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

Author

Petta, S., primary, Parrinello, G., additional, Di Marco, V., additional, Barcellona, M.R., additional, Cabibi, D., additional, Cammà, C., additional, Grimaudo, S., additional, Licata, A., additional, Pipitone, R.M., additional, Torres, D., additional, Marchesini, G., additional, Licata, G., additional, and Craxì, A., additional

Published
2013
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22. OC-11 PNPLA3 GG genotype is associated with carotid atherosclerosis in patients with non-alcoholic fatty liver disease

Author

Petta, S., primary, Parrinello, G., additional, Di Marco, V., additional, Licata, A., additional, Cammà, C., additional, Barcellona, M.R., additional, Cabibi, D., additional, Grimaudo, S., additional, Pipitone, M.R., additional, Torres, D., additional, Marchesini, G., additional, Licata, G., additional, and Craxì, A., additional

Published
2013
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24. P3 Insulin resistance and necroinflammation drives ductular reaction and epithelial-mesenchymal transition in chronic hepatitis C

Author

Pierantonelli, I., primary, Faraci, G., additional, Fabris, L., additional, Saccomanno, S., additional, Cadamuro, M., additional, Trozzi, L., additional, Bugianesi, E., additional, Guido, M., additional, Strazzabosco, M., additional, Benedetti, A., additional, Marchesini, G., additional, and Svegliati-Baroni, G., additional

Published
2010
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25. Practice guidelines for the diagnosis and management of nonalcoholic fatty liver disease

Author

Loria, P., primary, Adinolfi, L.E., additional, Bellentani, S., additional, Bugianesi, E., additional, Grieco, A., additional, Fargion, S., additional, Gasbarrini, A., additional, Loguercio, C., additional, Lonardo, A., additional, Marchesini, G., additional, Marra, F., additional, Persico, M., additional, Prati, D., additional, and Baroni, G. Svegliati-, additional

Published
2010
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32. Retinol-binding protein 4 (RBP4): A new marker of G1 HCV-induced steatosis

Author

Petta, S., primary, Cammà, C., additional, Di Marco, V., additional, Barbaria, F., additional, Cabibi, D., additional, Caldarella, R., additional, Ciminnisi, S., additional, Licata, A., additional, Massenti, Fatima, additional, Mazzola, A., additional, Tarantino, G., additional, Marchesini, G., additional, and Craxì, A., additional

Published
2008
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39. Non alcoholic fatty liver disease in Italy: a multicenter study

Author

Loguercio, C., primary, De Simone, T., additional, Agostinacchio, E., additional, Aiello, N., additional, Chiaramonte, M., additional, Fargion, S., additional, Grieco, A., additional, Marchesini, G., additional, Matarazzo, M., additional, Mecenate, F., additional, Persico, M., additional, Portincasa, P., additional, Svegliati Baroni, G., additional, Visconti, M., additional, and Del Vecchio Blanco, C., additional

Published
2001
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41. Reduced quality of life of patients with hepatocellular carcinoma

Author

Giulio Marchesini, D. Sgarbi, R Abbiati, Carmela Loguercio, G. P. Bianchi, T. De Simone, N. Brunetti, Marco Zoli, Bianchi G., Loguercio C., Sgarbi D., Abbiati R., Brunetti N., De Simone T., Zoli M., Marchesini G., Bianchi, G, Loguercio, Carmelina, Sgarbi, D, Abbiati, R, Brunetti, N, DE SIMONE, T, Zoli, M, and Marchesini, G.

Subjects
Hepatacellular carcinoma, Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Carcinoma, Hepatocellular, Cirrhosis, Logistic regression, Quality of life, Chronic hepatitis, Internal medicine, medicine, Health Status Indicators, Humans, In patient, Aged, Aged, 80 and over, Cirrhosi, Hepatology, business.industry, Liver Neoplasms, Gastroenterology, Antiviral therapy, Middle Aged, medicine.disease, Cross-Sectional Studies, Logistic Models, Nottingham Health Profile, Hepatocellular carcinoma, Quality of Life, Physical therapy, Female, business
Abstract

Background. It has been shown that health-related quality of life is reduced in patients with cirrhosis and with chronic hepatitis in relation to antiviral therapy. No data are available on patients with hepatocellular carcinoma. Aim. To assess health-related quality of life in cirrhotic patients with hepatocellular carcinoma. Patients and methods. Health-related quality of life was assessed in 101 hepatocellular carcinoma patients by means of Short Form-36 and Nottingham Health Profile questionnaires. Final scores of domains for individual patients were compared to age-adjusted normative Italian values, using Z-score and with values obtained in 202 matched patients with cirrhosis, without hepatocellular carcinoma. Results. All Short Form-36 domains and 4 out of 6 Nottingham Health Profile domains were altered. When hepatocellular carcinoma patients were compared with matched cirrhotics, differences were present for Bodily Pain, Role Limitation-Physical, and the Physical Component Summary of Short Form-36, as well as Pain of Nottingham Health Profile. Perceived health status had changed significantly in the year prior to assessment. Health-related quality of life was not primarily related to tumour mass or hepatocellular failure, whereas sleep disorders were selected by logistic regression as strongly associated with poor health-related quality of life. Conclusions. The present data stress the relevance of pain in poor perceived health status of hepatocellular carcinoma patients, and the importance of minor symptoms, such as sleep disorders. © 2002 Editrice Gastroenerologica Italiana S.r.l. Published by Elsevier Science Ireland Ltd. All rights reserved.

Published
2003

42. Genes and lifestyle: Which of the two is more relevant in driving NAFLD progression?

Author

Roy Taylor, Giulio Marchesini, Marchesini G., and Taylor R.

Subjects
Hepatology, Non-alcoholic Fatty Liver Disease, business.industry, Gastroenterology, Humans, Medicine, NAFLD, Genes, Lifestyle, business, Bioinformatics, Life Style, Gene
Abstract

A wide spectrum of factors conjointly operate in the pathogen- esis of NAFLD and in liver disease progression towards advanced liver disease and comorbidities [1]. At one extreme we find ge- netic factors: they provide mechanism(s) facilitating liver fat accu- mulation well before birth, as expressed by epigenetic studies [2], and are operative throughout life. In recent years several studies have shown that a lot of gene polymorphisms are associated with an increased risk of NAFLD, variably linked with obesity, with the risk of cardiovascular events, with the risk of progression to hep- atocellular cancer [3]. They have expanded to the area of NAFLD solid concepts linking non-communicable diseases to familial clus- tering and studies in homozygotic/dizygotic twins [4]. A few genes may also drive different outcomes, or make individuals more re- sistant to NAFLD development (protective genes) [5]. Scores have been generated to predict risks, although based on the number of mutated alleles, without any balance according to risk severity [6].

Published
2021

43. Psychological status and depression in patients with liver cirrhosis

Author

Giampaolo Bianchi, Giulio Marchesini, Carmela Loguercio, F. Nicolino, Marco Zoli, R Abbiati, D. Sgarbi, R. Graziani, G Bianchi, G Marchesini Reggiani, F Nicolino, R Graziani, D Sgarbi, C Loguercio, R Abbiati, M Zoli, Bianchi, G, Marchesini, G, Nicolino, F, Graziani, R, Sgarbi, D, Loguercio, Carmelina, Abbiati, R, and Zoli, M.

Subjects
Adult, Liver Cirrhosis, Male, Sleep Wake Disorders, medicine.medical_specialty, Cirrhosis, Alcohol Drinking, Disease, Severity of Illness Index, Liver disease, Surveys and Questionnaires, Severity of illness, medicine, Humans, Prospective Studies, Psychiatry, Aged, Aged, 80 and over, Psychiatric Status Rating Scales, Hepatology, Depression, business.industry, Gastroenterology, Beck Depression Inventory, Middle Aged, medicine.disease, Logistic Models, Psychological well-being, Quality of Life, Anxiety, Female, Liver function, medicine.symptom, business, Stress, Psychological, Clinical psychology
Abstract

Background. Previous studies reported an impairment of both the physical and mental dimensions of quality of life in patients with cirrhosis. Very few data are available on the psychological impact of the disease and its relation to liver function. Aim. To measure the psychological status of patients with cirrhosis in relation to the severity of the liver impairment. Patients and methods. One hundred and fifty-six patients with cirrhosis were studied. Two questionnaires (the Beck Depression Inventory and the Psychological General Well-Being Index) were self-administered in random order. Clinical and laboratory data were collected using standardised forms. Results. The global score of Psychological General Well-Being Index was severely reduced compared to Italian population norm. Among individual domains, the more severely affected was General Health, the less compromised was Positive Well-Being. A negative relation was found between Child–Pugh score (a comprehensive measure of disease severity) and global Psychological General Well-Being Index and several individual subscales. The Beck Depression Inventory scores were indicative of a depressed mood in over 50% of patients, in relation to the presence of clinical symptoms. Conclusions. Patients with cirrhosis have signs of psychological distress and depression, as assessed by Beck Depression Inventory and Psychological General Well-Being Index, in relation to the severity of liver disease. Accordingly, a non-negligible number of patients warrant treatment.

Published
2005

44. Reduced quality of life in patients with chronic hepatitis C: effects of interferon treatment

Author

D. Disalvo, Giulio Marchesini, G. P. Bianchi, C.H. Chen, Carmela Loguercio, R Abbiati, S. Natale, M. Di Pierro, D. Sgarbi, Bianchi, G, Loguercio, Carmelina, Sgarbi, D, Abbiati, R, Chen, Ch, DI PIERRO, M, Disalvo, D, Natale, S, and Marchesini, G.

Subjects
Adult, Male, medicine.medical_specialty, Cirrhosis, Liver disease, Quality of life, Surveys and Questionnaires, Internal medicine, medicine, Humans, Aged, Hepatitis, Hepatology, business.industry, Gastroenterology, Hepatitis C, Chronic, Middle Aged, medicine.disease, Family life, Distress, Nottingham Health Profile, Quality of Life, Physical therapy, Female, Interferons, business
Abstract

Background . Quality of life is an area of increasing interest in hepatology. Studies, so far, have assessed quality of life in patients with chronic virus C-related hepatitis in relation to antiviral therapy by means of generic questionnaires. Aim . To measure quality of life in chronic hepatitis patients without cirrhosis by means of the Nottingham Health Profile questionnaire, a measure of “distress” in comparison with the Medical Outcome Survey SF-36, an index of well-being. Patients . A series of 126 outpatients with chronic hepatitis; 37 on and 89 not on active interferon treatment. Methods . The two questionnaires were used in random order. Clinical and laboratory data were also collected. The final score of any domain of the two questionnaires, for any individual patient, was compared to age-adjusted normal values obtained in 2 random samples of Italian population. Results . Patients showed a significant modification of 3 domains of Nottingham Health Profile (Energy, Social Isolation and Physical Mobility) and 6 domains of SF-36. In relation to interferon treatment, the Nottingham Health Profile questionnaire was able to detect differences in Energy, Physical Mobility and Pain, which were modified only in treated patients. SF-36 did not show any differences in relation to treatment. In addition, the Nottingham Health Profile demonstrated that treated patients had a lower prevalence of concern for family life, possibly due to expectations of treatment itself. Conclusions . Active interferon treatment causes considerable distress in chronic hepatitis C patients, adding to the perceived change in health status caused by liver disease.

Published
2000

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