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Your search keyword '"Irene Degrassi"' showing total 6 results
Start Over Author "Irene Degrassi" Journal digestive and liver disease
6 results on '"Irene Degrassi"'

1. Diagnostic approach to neonatal and infantile cholestasis: A position paper by the SIGENP liver disease working group

Author

Maurizio Fuoti, Mara Cananzi, Giulia Paolella, Manila Candusso, Paola Francalanci, Lidia Monti, Emanuele Nicastro, Lorenzo D'Antiga, Carlo Dionisi Vici, Michele Pinon, Lorenza Matarazzo, Irene Degrassi, P. Gaio, Angelo Di Giorgio, Giusy Ranucci, Pier Luigi Calvo, Giuseppe Indolfi, Claudia Mandato, Fabio Mosca, Pietro Vajro, Maria Pia Bondioni, Maria Iascone, Maria Grazia Clemente, Federica Nuti, Marco Sciveres, Jean de Ville de Goyet, Claudia Della Corte, Marco Spada, Chiara Grimaldi, Federica Ferrari, Gabriella Nebbia, Giuseppe Maggiore, Fabio Fusaro, Daniele Serranti, Daniele Alberti, Fabiola Di Dato, Paola Roggero, Raffaele Iorio, and Giovanni Boroni

Subjects
Male, medicine.medical_specialty, Genetic liver disease, Alagille syndrome, Biliary atresia, Diagnosis, Inborn errors of metabolism, Jaundice, Monogenic liver disease, Newborn, Female, Gastroenterology, Humans, Infant, Infant, Newborn, Cholestasis, Evidence-Based Medicine, Infant, Newborn, Diseases, Practice Guidelines as Topic, Diseases, Disease, Liver disease, Epidemiology, medicine, Intensive care medicine, Hepatology, business.industry, medicine.disease, Etiology, Position paper, medicine.symptom, business
Abstract

Neonatal and infantile cholestasis (NIC) can represent the onset of a surgically correctable disease and of a genetic or metabolic disorder worthy of medical treatment. Timely recognition of NIC and identification of the underlying etiology are paramount to improve outcomes. Upon invitation by the Italian National Institute of Health (ISS), an expert working grouped was formed to formulate evidence-based positions on current knowledge about the diagnosis of NIC. A systematic literature search was conducted to collect evidence about epidemiology, etiology, clinical aspects and accuracy of available diagnostic tests in NIC. Evidence was scored using the GRADE system. All recommendations were approved by a panel of experts upon agreement of at least 75% of the members. The final document was approved by all the panel components. This position document summarizes the collected statements and defines the best-evidence diagnostic approach to cholestasis in the first year of life.

Published
2022

2. Pediatric autoimmune liver disease and extra-hepatic immune-mediated comorbidities

Author

C. Amoruso, Gabriella Nebbia, Giulia Paolella, Federica Nuti, M. Farallo, Irene Degrassi, and Carlo Agostoni

Subjects
Male, medicine.medical_specialty, Biopsy, Cholangitis, Sclerosing, Autoimmunity, Autoimmune hepatitis, Disease, Immunologic Tests, Gastroenterology, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Immune system, Liver Function Tests, Internal medicine, medicine, Humans, Child, Correlation of Data, Autoimmune liver disease, Retrospective Studies, Hepatology, business.industry, Thyroiditis, Autoimmune, Retrospective cohort study, medicine.disease, Ulcerative colitis, Celiac Disease, Hepatitis, Autoimmune, Italy, Liver, 030220 oncology & carcinogenesis, Abnormal Liver Function Test, Colitis, Ulcerative, Female, 030211 gastroenterology & hepatology, Bile Ducts, business, Immunosuppressive Agents
Abstract

Background Autoimmune liver disease (AILD) includes autoimmune hepatitis (AIH) and autoimmune sclerosing cholangitis (ASC). AILD is often associated with other extra-hepatic immune-mediated disorders (EDs), but there are few pediatric studies available to date. In this study we evaluated the association between AILD and EDs in our pediatric series. Methods In this single centre retrospective study 48 patients (39 AIH and 9 ASC children) were evaluated. Thirty-six children were primarily referred to our Centre for liver disease suspicion, while the remaining twelve had a previous diagnosis of EDs. All the patients were screened for various EDs at AILD diagnosis and yearly during the follow-up. Results Mean duration of follow-up was 9 years and 1 month. Twenty-two (46%) patients had a diagnosis of EDs. Ulcerative colitis (UC) was the most frequent EDs (9 patients), followed by autoimmune thyroid disease (5 patients) and celiac disease (5 patients). In 7 out of 9 UC patients, ASC was present. Conclusions Our study showed a high association (46%) between AILD and EDs. In particular, in 8 out of 9 ASC patients UC was diagnosed (p-value 0.007). It is important to look for EDs in AILD children and, conversely, AILD in EDs children with abnormal liver function tests.

Published
2019

4. Extra-hepatic autoimmune diseases in autoimmune hepatitis

Author

Giulia Paolella, M. Farallo, Gabriella Nebbia, Irene Degrassi, and Federica Nuti

Subjects
Hepatology, business.industry, Immunology, Gastroenterology, medicine, Autoantibody, Autoimmune hepatitis, medicine.disease, business
Published
2016

6. Neurological involvement in Crigler-Najjar type I syndrome: Role of liver transplantation

Author

Erica Finardi, Gabriella Nebbia, M. Farallo, Irene Degrassi, Lorenzo Fiorica, and Silvia Bettocchi

Subjects
medicine.medical_specialty, Univariate analysis, Hepatology, GI bleeding, business.industry, medicine.medical_treatment, Gastroenterology, Last follow up, Disease, Liver transplantation, Catheter, Internal medicine, medicine, business, Varices, Neonatal Disorder
Abstract

and umbilical venous catheter (UVC) placement, neonatal illnesses, type of presentation, results on pro-thrombotic screening and features at the last follow up. Results: We collected data on 187 patients from 9 centres; 46% were female, mean age at diagnosis was 3.8 years (SD 3.7). The neonatal associated factors were: presence of prematurity in 102/172 (59%), neonatal illnesses 70/132 (53%), history of UVC 107/165 (65%), congenital malformations 26/132 (19%), deep infections 11/132 (5%). The type of presentation was: detection of splenomegaly in 68 (39.5%), GI bleeding in 63 (37%), hypersplenism in 9 (5.2%), incidental in 32/172 patients (18%); 87% had oesophageal varices. Pro-thrombotic screening was positive in 30/76 (39.4%). After a follow up of 11.2 years (SD 4.8) 66% had been managed conservatively, 34% underwent surgery or TIPS. On univariate analysis a huge splenomegaly, GI bleeding and severe hypersplenism were predictors of surgery or TIPS (p

Published
2014

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